EFEKTIFITAS PELAKSANAAN ALOKASI DANA DESA BERDASARKAN PERMENDAGRI NO 113 TAHUN 2014 TENTANG PENGELOLAAN KEUANGAN DESA

The Organization of the Government of the village of terpisakan no peyelenggaraan autonomous region. Through law No. 6 Year 2014 about villages, each village given discretion to set its own kewenanganya, either the authority based on the origin of the local scale, the powers and authority of the village, in the transferred by the Central Government/provinces//kota in accordance with government legislation. This research uses the normative-empirical type. The data used in this research is the primary data, namely data obtained directly from the field in the form of interviews and questionnaires and secondary data, namely data obtained from graphical documents (tables, notes, meeting, meetings, etc), photographs, films, video recordings, and other things that can enrich the primary data.  Research results show that implementation of the allocation of Funds in the village of Banabungi Village have been implemented but in pelaksanaanya is not effective. It is based on is Not dilaksanakanya the principle of transparency and participatory in its own ruling, a factor pelaksanaanya i.e. the absence of legal sanctions or force power for the Government when the village does not implement legal norms. While the position of Permendagri NO. 113 Year 2014 about financial management is in compliance as regulations, although the above provision does not mention explicitly the type of legislation in the form of a regulation of the Minister, but the phrase rules set by Ministers at the top, reflecting the existence of ministerial regulation as one of the types of legislation. &nbsp

Peranan Kepala Desa dan Badan Permusyawaratan Desa dalam Pembangunan Desa Di desa Galanti Kecamatan Wolowa Kabupaten Buton

Studi ini bertujuan untuk mendeskripsikan peranan aparatur desa dalam menjalankan fungsinya sebagai eksekutor pengambil keputusan dan pemberi pelayanan bagi kepentingan kesejahteraan desa, di Desa Galanti, Kecamatan Wolowa, Kabupaten Buton. Adapun metode yang digunakan adalah metode kualitatif dengan pendekatan sosiologis. Pengambilan data penelitian dilakukan dengan  depth interview, observasi dan dokumentasi. Studi ini menunjukkan bahwa Aparatur Pemerintah Desa telah menjalankan peranannya dengan baik yang mana baik kepala desa maupun BPD  berupaya memberikan dukungan yang terbaik kepada masyarakat desa di berbagai bidang sesuai dengan kapasitas dan kapabilitas yang telah ditentukan. Aparatur Pemerintah Desa memberikan pelayanan seperti meningkatkan taraf hidup masyarakat dengan meningkatkan pendapatan, menghubungi dan mendatangkan pelayanan pertanian dan kesehatan sebagai bentuk kepedulian terhadap berbagai permasalahan yang dihadapi warganya

SOSIALISASI BAGI UMKM SARUNG TENUN TRADISIONAL TERHADAP HAK ATAS KEKAYAAN INTELEKTUAL DI KECAMATAN WABULA KABUPATEN BUTON

This community service aims to provide knowledge and understanding of Intellectual Property Rights for UMKM actors in Buton Regency. Micro, Small and Medium Enterprises (UMKM) have a very important role in encouraging the increase in the pace of the creative economy in the real sector of a nation, and are able to increase income for the community. Moreover, if it is added to the UMKM products, they already have intellectual property rights legally in their protection. The benefits of the role of Intellectual Property by business actors for UMKM products in Buton Regency so far have not been maximized, this is due to a lack of understanding in the community that the importance of Intellectual Property Rights as a form of legal protection from business competition over copyright claims so that there are still many UMKM products not yet available. registered as an example of a woven sarong product in the district of Wabula, Buton Regency. So in this service the need for socialization. In this socialization, several UMKM in traditional weaving sarongs were involved in Buton Regenc

Synthesis and biological activity of quaternary phosphonium salts based on 3-hydroxypyridine and 4-deoxypyridoxine

© 2016, Springer Science+Business Media New York.Methods for the synthesis of quaternary phosphonium salts based on 3-hydroxypyridine and 4-deoxypyridoxine were developed. Some of obtained compounds possess high antibacterial and antitumor activity in vitro

Antibacterial effects of quaternary bis-phosphonium and ammonium salts of pyridoxine on Staphylococcus aureus cells: A single base hitting two distinct targets?

We studied the effects of quaternary bis-phosphonium and bis-ammonium salts of pyridoxine with lipophilic substituents on the survival and morphology of Staphylococcus aureus cells. We found that, while originating from the same base, they exhibit considerably different antimicrobial mechanisms. In the presence of Ca(2+) ions the MIC and MBC values of ammonium salt increased 100-fold, suggesting that Ca(2+) ions can successfully impede the membrane Ca(2+) ions exchange required for ammonium salt incorporation. In contrast, in the presence of quaternary phosphonium salt, the artificial capsular-like material was formed around the cells and the filamentous and chain-like growth of the cells was observed suggesting the disruption of the cell division mechanisms. Altogether, both pyridoxine derivatives successfully inhibited the growth of gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis) and Escherichia coli considerably, while demonstrated nearly no effect against Klebsiella pneumoniae and Pseudomonas aeruginosa. We suggest that due to their effects on distinct and likely complementary targets the derivatives of pyridoxine represent potentially perspective antibacterials with complicated adaptation and thus with lower risk of drug resistance development

Synthesis and antibacterial activity of novel quaternary ammonium pyridoxine derivatives

© 2015 Bentham Science Publishers. A series of 26 quaternary ammonium pyridoxine derivatives were synthesized and their cytotoxicity and antibacterial activities against clinically relevant bacterial strains were tested in vitro. The antibacterial activity of mono-ammonium salts increased with the rise of the lipophilicity and compound 3,3,5-trimethyl-8,8-dioctyl-1,7,8,9-tetrahydro-[1,3]dioxino[5,4-d]pyrrolo[3,4-b]pyridin-8-ium chloride (2d) reaches a maximum among them. Bis-ammonium salt of pyridoxine 4 with two dimethyloctylamine groups also demonstrated high antibacterial activity despite lower lipophilicity. The results of MTT assay indicated that HEK 293 cells were more sensitive than HSF to quaternary ammonium pyridoxine derivatives. Compounds 2d and 4 did not induce the damage of the DNA and might be of interest in the development of new antimicrobials

Antibacterial effects of quaternary bis-phosphonium and ammonium salts of pyridoxine on Staphylococcus aureus cells: A single base hitting two distinct targets?

© 2015, Springer Science+Business Media Dordrecht. We studied the effects of quaternary bis-phosphonium and bis-ammonium salts of pyridoxine with lipophilic substituents on the survival and morphology of Staphylococcus aureus cells. We found that, while originating from the same base, they exhibit considerably different antimicrobial mechanisms. In the presence of Ca2+ ions the MIC and MBC values of ammonium salt increased 100-fold, suggesting that Ca2+ ions can successfully impede the membrane Ca2+ ions exchange required for ammonium salt incorporation. In contrast, in the presence of quaternary phosphonium salt, the artificial capsular-like material was formed around the cells and the filamentous and chain-like growth of the cells was observed suggesting the disruption of the cell division mechanisms. Altogether, both pyridoxine derivatives successfully inhibited the growth of gram-positive bacteria (Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis) and Escherichia coli considerably, while demonstrated nearly no effect against Klebsiella pneumoniae and Pseudomonas aeruginosa. We suggest that due to their effects on distinct and likely complementary targets the derivatives of pyridoxine represent potentially perspective antibacterials with complicated adaptation and thus with lower risk of drug resistance development

Synthesis, antibacterial and antitumor activity of methylpyridinium salts of pyridoxine functionalized 2-amino-6-sulfanylpyridine-3,5-dicarbonitriles

© 2018, © 2018 Taylor & Francis. A library of 29 2-amino-6-sulfanylpyridine-3,5-dicarbonitriles functionalized with a pyridoxine moiety was synthesized using a three-component one-pot reaction of aldehyde derivative of pyridoxine, malononitrile, and thiophenol. The obtained bipyridine structures were converted into methylpyridinium salts. Several compounds demonstrated expressed antibacterial activity with MICs (minimum inhibitory concentrations) in the range of 0.5–4 µg/mL against the three studied Gram-positive strains and 8–64 µg/mL against the Gram-negative E. coli strain, which was comparable or better than the activity of the reference antimicrobial agents. At the same time, all the synthesized compounds were inactive against the Gram-negative P. aeruginosa. Several compounds also demonstrated high cytotoxic activity against the studied tumor cells, but without selectivity for the normal HSF (human foreskin fibroblast) cells. Despite the preliminary character of the performed biological studies, the obtained results make the obtained structural chemotype a promising starting point for the design of physiologically active compounds

Revocation of Political Rights Convicted of Corruption In Every Judge's Decision as An Effort to Eradicate Corruption

The source of political rights inherent in human rights and political rights are also closely related to power. Meanwhile, corruptors who abuse their power are only sentenced to an average of 2 years and 2 months in prison during 2016; In 2013 the average sentence was 2 years 11 months; in 2014 2 years 8 months; and 2015 only 2 years 2 months. There needs to be a formulation of the provisions of the regulations as a basis for integrating and harmonizing judges' decisions on the revocation of political rights or it is also necessary to formulate a special criminal system to eradicate corruption crimes. Therefore, this study aims to examine what things underlie the enforcement of the deprivation of the political rights of the convicted of corruption in judge's decision and formulation of the criminal law system regarding the deprivation of political rights of convicted of corruption in judge's decision?. This research was conducted using a type of sociological juridical research approach. The result of the research is the abolition of political rights for corruption convicts, when examined from the juridical, sociological, and human rights aspects. It must become a standard in the punishment of corruption, considering that several formulations of the criminal law system currently exist in the criminal act of corruption which is still relatively light because the several sanctions given to date have not minimized acts of corruption

Peraturan Pemerintah Pengganti Undang-Undang Sebagai Dasar Pembentukan Lembaga Peradilan Khusus Pemilihan

Pemilu merupakan sarana yang sifatnya demokratis dalam memilih para wakil rakyat eksekutif dan legislative. Sering kali masalah dalam pemilu menjadi salah satu problem dalam penyelenggaraan pemilu yang efektif efisien, jujur dan adil, karena akan menghasilkan penyelesaian masalah yang tidak kuat dengan adanya beberapa lembaga yang menangani permasalahan pemilu sehingga ada potensi tumpang tindih dalam hal putusan lembaga yang satu dengan yang lainnya. oleh sebab itu diperlukan suatu pelembagaan untuk menyelesaikan permasalahan pemilu secara efektif, seperti membentuk peradilan khusus pemilu. Sebelum adanya undang-undang tentang peradilan khusus maka selama itu pula akan terjadi kekosongan hukum. Badan peradilan khusus hanya disebutkan dalam undang-undang Pilkada, tetapi tidak dijabarkan secara lanjut tentang kedudukan serta strukturnya. Oleh sebab itu, pengesahan peraturan tentang badan peradilan khusus sangat diperlukan demi mengisi kekosongan hukum. Pada penelitian ini penulis mengunakan jenis penelitian yuridis Normatif. Yuridis Normatif merupakan studi kasus normatif berupa produk hukum, misalnya mengkaji undang-undang. Pokok kajianya adalah hukum yang dikonsepkan sebagai norma atau kaidah yang berlaku dalam masyarakat dan menjadi acuan perilaku setiap orang. Sehingga penilitian yuridis normatif berfokus pada inventarisasi hukum positif, asas-asas dan doktrin hukum, taraf singkronisasi perbandingan hukum dan sejarah hukum. Oleh sebab itu, maka Perppu merupakan jawaban dari permasalahan. Hal ini yang dapat diharapkan untuk menambah terang solusi atas permasalahan terkait pemilu, maka pentingnya pembentukan badan peradilan khusus pemilu melalui Perppu yang memiliki ruang lingkup serta materi muatan yang sama dengan undang-undang, ditambah lagi waktu pembuatan Perppu yang lebih cepat dibandingkan dengan undang-undang,akan tetapi harus dalam keadaan “kegentingan yang memaksa”