Crowd behaviour at mass gatherings: A literature Review

Gaining an understanding of crowd behavior is important in supporting timely and appropriate crowd management principles in the planning and provision of emergency services at mass gatherings. This paper provides a review of the current understanding of the psychological factors of a crowd within the psychosocial domain as they apply to mass-gathering settings. It can be concluded from this review that there is a large theory-practice gap in relation to crowd psychology and the mass-gathering setting. The literature has highlighted two important elements of crowd behavior—there must be a “seed” and people must engage. Understanding these behaviors may provide opportunities to change crowd behavior outcomes

Developing an evaluation framework for clinical redesign programs : lessons learnt

Purpose – The purpose of this paper is to present lessons learnt through the development of an evaluation framework for a clinical redesign programme – the aim of which was to improve the patient journey through improved discharge practices within an Australian public hospital. Design/methodology/approach – The development of the evaluation framework involved three stages – namely, the analysis of secondary data relating to the discharge planning pathway; the analysis of primary data including field-notes and interview transcripts on hospital processes; and the triangulation of these data sets to devise the framework. The evaluation framework ensured that resource use, process management, patient satisfaction, and staff well-being and productivity were each connected with measures, targets, and the aim of clinical redesign programme. Findings – The application of business process management and a balanced scorecard enabled a different way of framing the evaluation, ensuring measurable outcomes were connected to inputs and outputs. Lessons learnt include: first, the importance of mixed-methods research to devise the framework and evaluate the redesigned processes; second, the need for appropriate tools and resources to adequately capture change across the different domains of the redesign programme; and third, the value of developing and applying an evaluative framework progressively. Research limitations/implications – The evaluation framework is limited by its retrospective application to a clinical process redesign programme. Originality/value – This research supports benchmarking with national and international practices in relation to best practice healthcare redesign processes. Additionally, it provides a theoretical contribution on evaluating health services improvement and redesign initiatives

How to evaluate redesigned clinical processes : lessons learnt

Evaluation is integral to clinical redesign programs, yet there is limited literature to guide how such an evaluation might be designed or conducted. To address this void, this paper presents the lessons learnt through the development of an evaluation framework for a clinical redesign program within an Australian public hospital. The evaluation framework ensured that resource use, process management, patient satisfaction, and staff wellbeing were each connected with measures, targets and the aim of the initiative. Lessons learnt include: (1) the importance of mixed-methods research to devise the framework and to evaluate the redesigned processes; (2) the need for appropriate tools and resources to adequately capture change across the different domains of the redesign program; and (3) the value of developing and applying an evaluative framework progressively, rather than retrospectively

Regulation of CaMKII in vivo: the importance of targeting and the intracellular microenvironment

CaMKII (calcium/calmodulin-stimulated protein kinase II) is a multifunctional protein kinase that regulates normal neuronal function. CaMKII is regulated by multi-site phosphorylation, which can alter enzyme activity, and targeting to cellular microdomains through interactions with binding proteins. These proteins integrate CaMKII into multiple signalling pathways, which lead to varied functional outcomes following CaMKII phosphorylation, depending on the identity and location of the binding partner. A new phosphorylation site on CaMKII (Thr253) has been identified in vivo. Thr253 phosphorylation controls CaMKII purely by targeting, does not effect enzyme activity, and occurs in response to physiological and pathological stimuli in vivo, but only in CaMKII molecules present in specific cellular locations. This new phosphorylation site offers a potentially novel regulatory mechanism for controlling functional responses elicited by CaMKII that are restricted to specific subcellular locations and/or certain cell types, by controlling interactions with proteins that are expressed in the cell at that location