Piperacillin/Tazobactam-Induced Neutropenia: A Case Report

Neutropenia, secondary to immune destruction or maturation arrest, is commonly described as an adverse hematological effect of beta-lactam antibiotics. A 29-year-old woman was being treated with piperacillin/tazobactam due to draining heel osteomyelitis. Herein, we present a case of reversible neutropenia occurring on the 25th day of treatment. Neutropenia resolved six days after discontinuation of piperacillin/tazobactam. We think that patients receiving prolonged treatment with piperacillin/tazobactam should be followed cautiously for neutropenia

Investigation of Legionella spp. from the Turkish Baths in Sivas

Legionella species are bacteria possibly found in every water environment and they are a part of ecocystem of water. The heat is an important criterion for amplification of bacterium and Legionella spp. were found more in hot springs water, hot water tanks. Plenty of outbreaks are connected with the systems of hot water. In this study, we investigated a total of 64 water samples for the presence of Legionella spp. The samples were collected from eight public baths in Sivas city center in July 2005. The water samples concentrated via filtration and decontamination (low pH) procedures were applied to the filtrates. After using a low pH method, the samples were cultured on BCYE and selective medium GVPC and MWY medium. All plates were incubated at 36°C in 90% humidified atmosphere for 10 days and examined daily. Oxidase, catalase, gelatinase, beta-lactamase, autofluorescence, hippurate hydrolysis and nitrate reduction methods are used for characterizing of Legionella-like organisms. Suspected colonies were confirmed by Legionella latex kit (Oxoid). As a result, Legionella spp. could not be isolated from the samples in this study

Adana İlinde Kronik Hepatit C’nin Değişen Epidemiyolojisi

Amaç: Bu çalışmada, Adana ilinde zaman içinde ortaya çıkan hepatit C virüsü (HCV) nün epidemiyolojik verileri ve genotip dağılımındaki değişikliklerin gösterilmesi amaçlanmıştır. Gereç ve Yöntemler: Kronik hepatit C tanısıyla, Ocak 1996-Mart 2013 tarihleri arasında takip edilen 369 hastanın verileri retrospektif olarak değerlendirilmiştir. Çalışmada, farklı genotipe sahip hastalar arasındaki cinsiyet, yaş ve bulaş yolu farklılıkları ve yıllara göre bölgemizdeki hastaların yaş ortalaması, cinsiyetleri ve virüs genotiplerindeki değişimler ele alınmıştır. Bulgular: Genotip 1, 289 (%78,3) hastada; genotip 2, 23 (%6,2) hastada; genotip 3, 54 (%14,6) hastada; genotip 4 ise 3 (%0,8) hastada tespit edildi. Yıllara göre genotip dağılımı incelendiğinde; 1996-2008 yılları arasında genotip 2 ve 3’e sahip hastaların oranı %2,7 iken, 2012-2013 yılları arasnda bu oranın %44’e yükseldiği görüldü. Genotip 2 veya 3’e sahip 77 hastanın 69 (%89,6)’sında intravenöz ilaç bağımlılığı vardı. Sonuç: Son yıllarda damar içi ilaç kullanımına bağlı HCV enfeksiyonu bölgemizde artış göstermiştir. Hastaların yaş ortalamasındaki düşüş, erkek cinsiyette daha sık görülür olması ve genotip 2 ve 3 oranlarındaki artış bu nedene bağlanmıştır.Objective: Our study aimed to demonstrate the epidemiological data of hepatitis C virus (HCV) and changes in its genotypic distribution which was observed in Adana in time. Materials and Methods: The data from 369 patients who were on follow up with the diagnosis of chronic hepatitis C between January 1996 and March 2013, were reviewed retrospectively. The differences between the gender, age, and routes of transmission among the HCV patients with different genotypes were reviewed. Changes in the mean age, gender, and virus genotypes of the patients in our region by the years were evaluated. Results: Genotype 1 was identified in 289 (78.3%) patients, genotype 2 in 23 (6.2%) patients, genotype 3 in 54 (14.6%) patients and genotype 4 was identified in 3 (0.8%) patients. When the genotypic distribution over the years was assessed, the rate of the patients with genotype 2 or 3 was 2.7% between 1996 and 2008, this rate was observed to increase to 44% between 2012 and 2013. Sixty nine out of 77 (89.6%) patients with genotype 2 or 3 were intravenous drug addicts. Conclusion: In our region intravenous drug use-related HCV infection was increased in recent years. Decrease in the mean age of the patients, higher probability of occurrence among males and increased rates of genotype 2 and 3 were associated with this reason