153 research outputs found

    Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry

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    Education and ICT-based self-regulation in learning: Theory, design and implementation

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    Ambulatory blood pressure monitoring and target organ damage in pediatrics

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    The prevalence of hypertension in children and adolescents is rising in association with the increasing rate of childhood obesity, and it is associated with early target organ damage. Published guidelines on high blood pressure in children and adolescents, focused on the early and accurate diagnosis of hypertension, resulted in improved ability to identify children with hypertension. Although auscultation using a mercury sphygmomanometer remains the method of choice for evaluation of hypertension in children, accumulating evidence suggests that ambulatory blood pressure monitoring is a more accurate method for diagnosis, and it is more closely associated with target organ damage. In addition, ambulatory blood pressure monitoring is a valuable tool in the assessment of white-coat hypertension, and masked hypertension in children and adolescents. Masked hypertension in children and adolescents is associated with a similar risk of target organ damage as in established hypertension. © 2007 Lippincott Williams & Wilkins, Inc

    Effect of hypotensive drugs on the circadian blood pressure pattern in essential hypertension: A comparative study

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    To compare the effect of four drug groups on the ambulatory circadian blood pressure (BP) pattern, amiloride hydrochlorothiazide, atenolol, nifedipine, and perindopril (5/50 mg/d, 100 mg/d, 40 mg/d, and 4 mg/d respectively, for 14 days) were alternated in each of 20 essential hypertension patients. Diuretics induced the largest (P < 0.05) drop in mean 24-hour systolic BP (-12 mmHg, P < 0.001). Atenolol reduced only its standard deviation, and nifedipine reduced only the mean daytime systolic BP (P < 0.05). The mean 24-hour diastolic BP was equally reduced by all drugs except nifedipine, which only reduced (P < 0.05) the mean daytime value. The mean 24-hour heart rate was decreased by atenolol (P < 0.001), increased by diuretics (P < 0.05), and unchanged with perindopril, while nifedipine increased (P < 0.05) only its night-time value. In conclusion, diuretics were the strongest agents in reducing systolic BP, atenolol the only agent that reduced variability, perindopril the only agent that did not affect the heart rate, and nifedipine reduced only daytime BP values
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