Inferring the diagnostic potential of 18F-FDG-PET/CT in post-renal transplantation from a unique case harboring multiple rare complications

Renal transplantation is undoubtedly an effective treatment for patients with end-stage renal disease, but it is certainly not a cure. Patients require lifelong immunosuppression to maintain optimal allograft function, and post-operative risk complications such as cancer in the transplant recipient cannot be ignored. Besides, infection is a silent complication that follows transplantation. Relatedly, herein, we present a report of a 40-year-old patient who underwent renal transplantation and promptly developed a diffuse large B-cell tumor in the liver and Aspergillus infection in the trachea. In addition, an inflammatory necrotizing granuloma was also observed in the muscles. Of importance, we also described the potential of 18F-FDG-PET/CT, which was instrumental in monitoring and evaluating these relevant post-operative complications in this rare case

Novel albumin-binding multifunctional probe for synergistic enhancement of FL/MR dual-modal imaging and photothermal therapy

The fluorescence/magnetic resonance (FL/MR) dual-modal imaging could provide accurate tumor visualization to guide photothermal therapy (PTT) of cancer, which has attracted widespread attention from scientists. However, facile and effective strategies to synergistically enhance fluorescence intensity, MR contrast and photothermal efficacy have rarely been reported. This study presents a novel multifunctional probe Gd-EB-ICG (GI) for FL/MR dual-modal imaging-guided PTT of cancer. GIs can self-assemble with endogenous albumin to form drug-albumin complexes (GIAs), which exhibit excellent biocompatibility. Albumin can protect GIAs from the recognition and clearance by the mononuclear phagocytic system (MPS). High plasma concentration and long half-life allow GIAs to accumulate continuously in the tumor area through EPR effect and specific uptake of tumor. Because of the prolonged rotational correlation time (τR) of Gd chelates, GIAs exhibited superior MR contrast performance over GIs with more than 3 times enhancement of longitudinal relaxation efficiency (r1). The fluorescence quantum yield and photothermal conversion efficiency of GIAs was also significantly improved due to the constrained geometry, disrupted aggregation and enhanced photothermal stability. This simple and feasible strategy successfully resulted in a synergistic effect for FL/MR dual-modal imaging and photothermal therapy, which can cast a new light for the clinical translation of multifunctional probes

Take Shuibu Town of Taishan city as an example to study the application of GIS in small towns under the background of “Muti-planning integration”

With the proposal of land planning strategy and the development of GIS information technology and big data, geographic information technology and big data are widely used in the field of urban and rural planning, providing new technical support for the implementation of “muti-planning integration”. As the reserve force for development, small towns have great research value. This study selects Shuibu Town of Taishan city to study the construction and management of Urban Land GIS database in order to provide working ideas for the construction of GIS data platform in small towns

The Profitability of Technical Trading for Hotel Stocks under COVID-19 Pandemic

In the real world, investors believe that they can receive more returns for trading stocks by utilizing technical analysis. However, due to the seriously worldwide breakout of COVID-19 from 2020, investors are not sure if they could outperform the market by applying the technical trading rules during this severe period. Thus, we conduct this study to investigate the profitability of stock trading with the use of technical indicators under COVID-19 pandemic. By trading the constituent stocks of Hotel Stock 20 Index (HSI 20) whose stock prices seem considerably declined after the outbreak of COVID-19, we discover that most of the trading rules utilized in this study fail to beat the market in the first half of the year 2020. The findings of this study may shed light on that investors should adopt technical trading rules with care when stock markets are severely affected by black swan events, such as COVID-19. We argue that the above issue would be rather impressive not only for market participants to avoid losses, even make profits, but also for the existing literature due to the rare discussion in the past.補正完畢TW

The profitability of Technical Trading for Hotel Stocks Under COVID-19 Pandemic

[[notice]]補正完

Does CBOE volatility index jumped or located at a higher level matter for evaluating DJ 30, NASDAQ, and S&P500 index subsequent performance

[[abstract]]Nowadays, the VIX index has become the most popular measure for the market’s expectation of volatility over the near-term future. Studies have addressed that the sharp movement in the VIX index might affect stock markets. However, the subsequent performances for stock markets when the VIX index jumps a relatively high point in a day or is located at a relatively high level remain unclear in the present literature. With the motivation to solve these puzzles, we conduct this study by taking “flow concern” and “stock concern” to evaluate the interaction among Dow Jones, NASDAQ, and S&P500 and VIX indices. The revealed results show that the subsequent performances for these stock indices would rise in a few days, but the above results would be reversed in a month. These findings might be beneficial for investors in evaluating DJ 30, NASDAQ, and S&P500 index subsequent performance while trading these index futures or index ETFs as the above VIX index phenomena occurred. Additionally, we argue that the above concerns in terms of investors’ panic and stock index performance, to our knowledge, seem rarely explored before and the outcomes of this study might enhance the robustness of the existing literature.[[notice]]補正完

Recent developments on electron optics simulator

Recent developments on the electron optics simulator (EOS) are reported in this paper. The EOS is a finite element two-dimensional (2D) and three-dimensional (3D) electrostatic particle steady-state trajectory code that has been widely used for beam optics modeling of vacuum electronic devices. To extend the application scope and improve the computation efficiency, four significant advances have been made and are presented in this paper. First, the code is reprogrammed to consider physical models that contain dielectrics and to support charge excitation. Second, more primary particle emission models are added in EOS to meet the needs for simulating electron and ion optics devices for diverse applications. For the precise simulation of the secondary electron emission, the Vaughan model is improved, and the Furman model is newly added in EOS. Finally, the algebraic multigrid algorithm has been embedded in EOS, which can significantly improve the computation efficiency for problems with large-scale matrices. For these developments, the necessary principles and corresponding performance are shown in detail in this paper

Supplementary_table – Supplemental material for Genetic variants in miRNA machinery genes associated with clinicopathological characteristics and outcomes of gastric cancer patients

<p>Supplemental material, Supplementary_table for Genetic variants in miRNA machinery genes associated with clinicopathological characteristics and outcomes of gastric cancer patients by Yuqian Liao, Yulu Liao, Jun Li, Liyan Liu, Junyu Li, Yiye Wan and Lixiang Peng in The International Journal of Biological Markers</p

Bioinformatics-based prediction of conformational epitopes for human parechovirus.

Human parechoviruses (HPeVs) are human pathogens that usually cause diseases ranging from rash to neonatal sepsis in young children. HPeV1 and HPeV3 are the most frequently reported genotypes and their three-dimensional structures have been determined. However, there is a lack of systematic research on the antigenic epitopes of HPeVs, which are useful for understanding virus-receptor interactions, developing antiviral agents or molecular diagnostic tools, and monitoring antigenic evolution. Thus, we systematically predicted and compared the conformational epitopes of HPeV1 and HPeV3 using bioinformatics methods in the study. The results showed that both epitopes clustered into three sites (sites 1, 2 and 3). Site 1 was located on the "northern rim" near the fivefold vertex; site 2 was on the "puff"; and site 3 was divided into two parts, of which one was located on the "knob" and the other was close to the threefold vertex. The predicted epitopes highly overlapped with the reported antigenic epitopes, which indicated that the prediction results were accurate. Although the distribution positions of the epitopes of HPeV1 and HPeV3 were highly consistent, the residues varied largely and determined the genotypes. Three amino acid residues, VP3-91N, -92H and VP0-257S, were the key residues for monoclonal antibody (mAb) AM28 binding to HPeV1 and were also of great significance in distinguishing HPeV1 and HPeV3. We also found that two residues, VP1-85N and -87D, might affect the capability of mAb AT12-015 to bind to HPeV3