MOESM1 of Plasma preparation to measure FDA-approved protein markers by selected reaction monitoring

Additional file 1: Figure S1. Extracted ion chromatograms of native and isotopically labelled proteotypic peptides (marked as “NAT” and “SIS”, respectively) obtained with Skyline software for the peptides of PlasmaDeepDive™ kit in Series #3: а SVLGQLGITK (Alpha 1-antitrypsin, P01009), 1592 fM; b GGYTLVSGYPK (Hemopexin, P02790), 475 fM; c GYTQQLAFR (Complement C3, P01024), 22 fM; d AVSPLPYLR (von Willebrand factor, P04275), 2 fM. Dashed lines indicate peak integration boundaries

MOESM4 of Plasma preparation to measure FDA-approved protein markers by selected reaction monitoring

Additional file 4: Figure S3. Comparison between protein concentration measured by SRM (Series #3) and by other approaches [14]

MOESM3 of Plasma preparation to measure FDA-approved protein markers by selected reaction monitoring

Additional file 3: Figure S2. Mean values of the coefficient of variation among technical runs in different series of measurement. Each point corresponds to the proteins detected in three technical runs (nine proteins in Series #1 and Series #3, and 11 proteins in Series #2)