19 research outputs found
Biobased Heat-Triggered Shape-Memory Polymers Based on Polylactide/Epoxidized Natural Rubber Blend System Fabricated via Peroxide-Induced Dynamic Vulcanization: Co-continuous Phase Structure, Shape Memory Behavior, and Interfacial Compatibilization
A biobased
heat-triggered shape-memory polymer (HSMP) consisting
of polylactide (PLA) and epoxidized natural rubber (ENR) was fabricated
by peroxide-induced dynamic vulcanization. The cross-linked ENR phase
exhibits a continuous net-like structure embedded in the PLA phase,
which is different from a conventional plastic/rubber system having
the typical âseaâislandâ morphology in which
vulcanized rubber particles were dispersed in plastic matrix. In situ
interfacial compatibilization was confirmed by FTIR analysis. The
shape-recovery ratios of the PLA/ENR HSMPs were significantly improved
over 90%, compared to that (60â70%) of PLA. The shape fixing
and memorizing capability of PLA/ENR HSMPs was realized by the glass
transition of the PLA phase: cross-linked ENR continuous phase at
rubbery state offered strong recovery driving force, improved interface
provided effective stress-transferring during shape recovery, and
PLA continuous phase served as a âcontrol-switchâ for
recovery. The biobased PLA/ENR HSMP could serve as a promising alternative
to the traditional materials for intelligent biomedical devices
Biobased Heat-Triggered Shape-Memory Polymers Based on Polylactide/Epoxidized Natural Rubber Blend System Fabricated via Peroxide-Induced Dynamic Vulcanization: Co-continuous Phase Structure, Shape Memory Behavior, and Interfacial Compatibilization
A biobased
heat-triggered shape-memory polymer (HSMP) consisting
of polylactide (PLA) and epoxidized natural rubber (ENR) was fabricated
by peroxide-induced dynamic vulcanization. The cross-linked ENR phase
exhibits a continuous net-like structure embedded in the PLA phase,
which is different from a conventional plastic/rubber system having
the typical âseaâislandâ morphology in which
vulcanized rubber particles were dispersed in plastic matrix. In situ
interfacial compatibilization was confirmed by FTIR analysis. The
shape-recovery ratios of the PLA/ENR HSMPs were significantly improved
over 90%, compared to that (60â70%) of PLA. The shape fixing
and memorizing capability of PLA/ENR HSMPs was realized by the glass
transition of the PLA phase: cross-linked ENR continuous phase at
rubbery state offered strong recovery driving force, improved interface
provided effective stress-transferring during shape recovery, and
PLA continuous phase served as a âcontrol-switchâ for
recovery. The biobased PLA/ENR HSMP could serve as a promising alternative
to the traditional materials for intelligent biomedical devices
Fully Biobased Shape Memory Material Based on Novel Cocontinuous Structure in Poly(Lactic Acid)/Natural Rubber TPVs Fabricated via Peroxide-Induced Dynamic Vulcanization and in Situ Interfacial Compatibilization
Shape
memory polymers (SMPs) based on fully biobased polyÂ(lactide) (PLA)/natural
rubber (NR) thermoplastic vulcanizates (TPVs) were fabricated via
peroxide-induced dynamic vulcanization. Simultaneously, in situ reactive
compatibilization was achieved by PLA molecule grafting onto NR chains.
Differing from the general concept of spherical rubber particles being
formed after dynamic vulcanization, the cross-linked NR was found
to be a ânetlikeâ continuous phase in the PLA matrix.
This novel structure explained the surprising shape memory property
of PLA/NR TPVs well (shape fixities ⌠100%, shape recoveries
> 95%, and fast recovery speed < 15 s at the switching temperature,
âŒ60 °C): the cross-linked NR continuous phase offers strong
resilience and the PLA phase serves as the heat-control switch. We
envision that the âgreenâ raw materials and excellent
shape memory properties of the dynamically vulcanized PLA/NR SMPs
will open up a wide range of potential applications in intelligent
medical devices
Preparation of Superelastic, Durable, and Lightweight Composite Foams Based on Multiple Cross-Linked Network Regulated Structures
The polymer material foaming technology plays an important
role
in energy conservation and emission reduction. However, modulating
the structure of rubber/plastic foams to achieve low weight and high
resilience is still a challenge. In this paper, ethylene vinyl acetate
polymer (EVA)/epoxidized natural rubber (ENR) foams are prepared by
chemical foaming kettle compression molding (KCM) with multiple cross-linked
network structures consisting of covalent cross-links of EVAâEVA
and ENRâENR and hydrogen-bonded cross-linked networks between
hydroxyl and ester groups. As influenced by the hydrogen-bonded cross-linked
networks, the cellular restructuring of EVA/ENR foams is no longer
limited to changes in the rubber/plastic content. Compared to pure
EVA foams, EVA/ENR foams show advantages such as a low weight (13.95
Ă 1010 cells/density), a higher ductility (3.42 MJ/m3), a higher resilience (50%), and superior durability (more
than 200 cycles at 50% compression). Moreover, due to the binding
and anchoring effect of the ENR molecular chains, the thermal stability
of EVA/ENR foams is greatly enhanced, with an initial decomposition
temperature of around 320 °C, compared to that of EVA foams (âŒ150
°C). Considering the excellent properties of the EVA/ENR foams
and the low cost of the KCM, the present strategy proposes an easy-to-industrialize
method of fabricating rubber/plastic composite foams with high mechanical
properties
Design of Self-Healing Supramolecular Rubbers by Introducing Ionic Cross-Links into Natural Rubber via a Controlled Vulcanization
Introducing ionic associations
is one of the most effective approaches to realize a self-healing
behavior for rubbers. However,
most of commercial rubbers are nonpolar rubbers without now available
functional groups to be converted into ionic groups. In this paper,
our strategy was based on a controlled peroxide-induced vulcanization
to generate massive ionic cross-links via polymerization of zinc dimethacrylate
(ZDMA) in natural rubber (NR) and exploited it as a potential self-healable
material. We controlled vulcanization process to retard the formation
of covalent cross-link network, and successfully generated a reversible
supramolecular network mainly constructed by ionic cross-links. Without
the restriction of covalent cross-linkings, the NR chains in ionic
supramolecular network had good flexibility and mobility. The nature
that the ionic cross-links was easily reconstructed and rearranged
facilitating the self-healing behavior, thereby enabling a fully cut
sample to rejoin and retain to its original properties after a suitable
self-healing process at ambient temperature. This study thus demonstrates
a feasible approach to impart an ionic association induced self-healing
function to commercial rubbers without ionic functional groups
Table1_Investigating the immune mechanism of natural products in the treatment of lung cancer.XLSX
With the deepening of peopleâs understanding of lung cancer, the research of lung cancer immunotherapy has gradually become the focus of attention. As we all know, the treatment of many diseases relies on the rich sources, complex and varied compositions and wide range of unique biological properties of natural products. Studies have shown that natural products can exert anticancer effects by inducing tumor cell death, inhibiting tumor cell proliferation, and enhancing tumor cell autophagy. More notably, natural products can adjust and strengthen the bodyâs immune response, which includes enhancing the function of NK cells and promoting the differentiation and proliferation of T lymphocytes. In addition, these natural products may enhance their anticancer effects by affecting inhibitory factors in the immune system, hormone levels, enzymes involved in biotransformation, and modulating other factors in the tumor microenvironment. The importance of natural products in lung cancer immunotherapy should not be underestimated. However, the specific links and correlations between natural products and lung cancer immunity are not clear enough, and further studies are urgently needed to clarify the relationship between the two. In this paper, we will focus on the correlation between natural products and lung cancer immune responses, with a view to providing new research perspectives for immunotherapy of lung cancer.</p
Bio-Based PLA/NR-PMMA/NR Ternary Thermoplastic Vulcanizates with Balanced Stiffness and Toughness: âSoftâHardâ CoreâShell Continuous Rubber Phase, In Situ Compatibilization, and Properties
Stiffness and toughness
are two mutually exclusive attributes of
polymer materials that contribute to significant improvements in impact
strength, usually accompanied by a reduction in tensile strength.
In this study, ternary thermoplastic vulcanizates (TPVs) consisting
of polyÂ(lactic acid) (PLA), polyÂ(methyl methacrylate)-grafted natural
rubber (NR-PMMA), and natural rubber (NR) with balanced stiffness
and toughness were successfully prepared via peroxide-induced dynamic
vulcanization. With 10 wt% of NR and NR-PMMA, the PLA/NR-PMMA/NR ternary
TPV displayed an enhanced yield stress of 41.7 MPa (only 38% loss
compared to neat PLA) and a significantly higher impact strength of
91.30 kJ/m<sup>2</sup> (nearly 32 times that of neat PLA). The in
situ compatibilization between PLA and rubber phases was confirmed
by Fourier transform infrared spectroscopy. Interfacial, rheological,
and calorimetric measurements confirmed that the NR was encapsulated
by NR-PMMA in the PLA phase. It was found that the flexibility of
the âsoftâ NR core and outer âhardâ NR-PMMA
shell with excellent PLA/rubber interfacial adhesion are responsible
for the super toughness and considerable tensile strength of the PLA/NR-PMMA/NR
ternary TPVs
Self-Healing Natural Rubber with Tailorable Mechanical Properties Based on Ionic Supramolecular Hybrid Network
In
most cases, the strength of self-healing supramolecular rubber based
on noncovalent bonds is in the order of KPa, which is a challenge
for their further applications. Incorporation of conventional fillers
can effectively enhance the strength of rubbers, but usually accompanied
by a sacrifice of self-healing capability due to that the filler system
is independent of the reversible supramolecular network. In the present
work, in situ reaction of methacrylic acid (MAA) and excess zinc oxide
(ZnO) was realized in natural rubber (NR). Ionic cross-links in NR
matrix were obtained by limiting the covalent cross-linking of NR
molecules and allowing the in situ polymerization of MAA/ZnO. Because
of the natural affinity between Zn<sup>2+</sup> ion-rich domains and
ZnO, the residual nano ZnO participated in formation of a reversible
ionic supramolecular hybrid network, thus having little obstructions
on the reconstruction of ionic cross-links. Meanwhile, the well dispersed
residual ZnO could tailor the mechanical properties of NR by changing
the MAA/ZnO molar ratios. The present study thus provides a simple
method to fabricate a new self-healing NR with tailorable mechanical
properties that may have more potential applications
Image_1_Transcription factors NF-YB involved in embryogenesis and hormones responses in Dimocarpus Longan Lour.jpeg
IntroductionNF-YB transcription factor is an important regulatory factor in plant embryonic development.ResultsIn this study, 15 longan NF-YB (DlNF-YB) family genes were systematically identified in the whole genome of longan, and a comprehensive bioinformatics analysis of DlNF-YB family was performed. Comparative transcriptome analysis of DlNF-YBs expression in different tissues, early somatic embryogenesis (SE), and under different light and temperature treatments revealed its specific expression profiles and potential biological functions in longan SE. The qRT-PCR results implied that the expression patterns of DlNF-YBs were different during SE and the zygotic embryo development of longan. Supplementary 2,4-D, NPA, and PP333 in longan EC notably inhibited the expression of DlNF-YBs; ABA, IAA, and GA3 suppressed the expressions of DlNF-YB6 and DlNF-YB9, but IAA and GA3 induced the other DlNF-YBs. Subcellular localization indicated that DlNF-YB6 and DlNF-YB9 were located in the nucleus. Furthermore, verification by the modified 5'RNA Ligase Mediated Rapid Amplification of cDNA Ends (5' RLM-RACE) method demonstrated that DlNF-YB6 was targeted by dlo-miR2118e, and dlo-miR2118e regulated longan somatic embryogenesis (SE) by targeting DlNF-YB6. Compared with CaMV35S- actuated GUS expression, DlNF-YB6 and DlNF-YB9 promoters significantly drove GUS expression. Meanwhile, promoter activities were induced to the highest by GA3 but suppressed by IAA. ABA induced the activities of the promoter of DlNF-YB9, whereas it inhibited the promoter of DlNF-YB6.DiscussionHence, DlNF-YB might play a prominent role in longan somatic and zygotic embryo development, and it is involved in complex plant hormones signaling pathways.</p
Table_1_Transcription factors NF-YB involved in embryogenesis and hormones responses in Dimocarpus Longan Lour.docx
IntroductionNF-YB transcription factor is an important regulatory factor in plant embryonic development.ResultsIn this study, 15 longan NF-YB (DlNF-YB) family genes were systematically identified in the whole genome of longan, and a comprehensive bioinformatics analysis of DlNF-YB family was performed. Comparative transcriptome analysis of DlNF-YBs expression in different tissues, early somatic embryogenesis (SE), and under different light and temperature treatments revealed its specific expression profiles and potential biological functions in longan SE. The qRT-PCR results implied that the expression patterns of DlNF-YBs were different during SE and the zygotic embryo development of longan. Supplementary 2,4-D, NPA, and PP333 in longan EC notably inhibited the expression of DlNF-YBs; ABA, IAA, and GA3 suppressed the expressions of DlNF-YB6 and DlNF-YB9, but IAA and GA3 induced the other DlNF-YBs. Subcellular localization indicated that DlNF-YB6 and DlNF-YB9 were located in the nucleus. Furthermore, verification by the modified 5'RNA Ligase Mediated Rapid Amplification of cDNA Ends (5' RLM-RACE) method demonstrated that DlNF-YB6 was targeted by dlo-miR2118e, and dlo-miR2118e regulated longan somatic embryogenesis (SE) by targeting DlNF-YB6. Compared with CaMV35S- actuated GUS expression, DlNF-YB6 and DlNF-YB9 promoters significantly drove GUS expression. Meanwhile, promoter activities were induced to the highest by GA3 but suppressed by IAA. ABA induced the activities of the promoter of DlNF-YB9, whereas it inhibited the promoter of DlNF-YB6.DiscussionHence, DlNF-YB might play a prominent role in longan somatic and zygotic embryo development, and it is involved in complex plant hormones signaling pathways.</p