Clinical characteristics of patients with brucellosis.

<p>Clinical characteristics of patients with brucellosis.</p

Laboratory results of patients with brucellosis.

<p>Laboratory results of patients with brucellosis.</p

Baseline demographics of patients with brucellosis.

<p>Baseline demographics of patients with brucellosis.</p

Treatment plan, follow-up and prognosis.

<p>Treatment plan, follow-up and prognosis.</p

Association between the PNPLA3 I148M Polymorphism and Non-Alcoholic Fatty Liver Disease in the Uygur and Han Ethnic Groups of Northwestern China

<div><p>Objective</p><p>Multiple common gene variants play a role in non-alcoholic fatty liver disease (NAFLD) susceptibility. Our goal was to investigate the association between variants polymorphisms and NAFLD in the Uygur and Han from Northwestern China.</p><p>Methods</p><p>Eight tag single nucleotide polymorphisms (tSNPs) previously reported to be associated with NAFLD were characterized in 396 NAFLD individuals and 399 controls. The association of variants with NAFLD in the Uygur and Han was assessed using the chi-squared (χ²) test in different gene models. Unconditional logistic regression analysis was performed to obtain the odds ratios (ORs) for risk of NAFLD and their 95% confidence intervals (CI), adjusted for confounding factors. Finally, stratified analysis was used to explore the potential gene-environment interactions on the risk of NAFLD.</p><p>Results</p><p>In a recessive model, we found a potential association between rs738409 and NAFLD in both ethnic groups: Chinese Han (OR = 1.84, 95% CI: 1.03–3.27, <i>p</i> = 0.036), Uygur (OR = 2.25, 95% CI: 1.23–4.09, <i>p</i> = 0.006). The multiple logistic regression revealed that <i>PNPLA3 rs738409</i> GG genotype may increase the risk of NAFLD by adjusting some confounding factors: Han (OR = 5.22, 95% CI: 1.94–14.04, <i>p</i> = 0.001), Uygur (OR = 4.29, 95% CI: 1.60–11.48, <i>p</i> = 0.004). Stratified analysis found that rs738409 polymorphism appeared to have interaction with sex, smoking status in Uygur, and have interaction with sex, age, BMI stage, lifestyle in Han.</p><p>Conclusion</p><p>Our data suggest the PNPLA3 I148M polymorphism influences susceptibility to NAFLD in the Han and Uygur of Northwestern China.</p></div

Association between <i>PNPLA3</i> and risk of NAFLD based on multiple logistic regression analysis, adjusted for confounding factors.

<p>*<i>p</i><0.05 indicates statistical significance.</p><p>Association between <i>PNPLA3</i> and risk of NAFLD based on multiple logistic regression analysis, adjusted for confounding factors.</p

Combined effects of <i>PNPLA3</i> rs738409 polymorphisms and environmental and ‘internal’ exposures on the risk of NAFLD.

<p>*<i>p</i><0.05 indicates statistical significance.</p><p>Combined effects of <i>PNPLA3</i> rs738409 polymorphisms and environmental and ‘internal’ exposures on the risk of NAFLD.</p

Basic information on candidate tSNPs for NAFLD.

<p>HWE: Hardy-Weinberg equilibrium.</p><p>*p<0.1 indicates statistical significance.</p><p>**p<0.05 indicates statistical significance.</p><p>Basic information on candidate tSNPs for NAFLD.</p

Variable genetic models of the association between the PNPLA3 I148M polymorphism (rs738409) and NAFLD in the Uygur and Han of Northwestern China.

<p><b>*</b><i>p</i><0.05 indicates statistical significance.</p><p>Variable genetic models of the association between the PNPLA3 I148M polymorphism (rs738409) and NAFLD in the Uygur and Han of Northwestern China.</p

Additional file 8 of Functional structure analysis and genome-wide identification of CNX gene family in cotton

Additional file 8. Table S8: Relative expression levels of 8 selected genes under four abiotic stresses