1 research outputs found
Rapid Access to Spirocylic Oxindoles: Application of Asymmetric N‑Heterocyclic Carbene-Catalyzed [3 + 3] Cycloaddition of Imines to Oxindole-Derived Enals
A chiral
N-heterocyclic carbene (NHC)-catalyzed [3 + 3] cycloaddition
reaction of imines and oxindole-derived enals was developed for rapid
access to spirocylic oxindoles. In most cases, the desired spirocylic
oxindole products were obtained in high yields and excellent enantioselectivities
with less than 1 h of reaction time