Dual roles in information mediation at work: Analysis of advice‐receiving and advice‐providing diary surveys

In everyday work, people often turn to their colleagues for information. Those colleagues play the role of information mediators by intervening in the information seeking and use of others. This study investigates how people initiate the information mediation process, how they influence one another's subsequent information behavior, and how they benefit from the process, from the perspectives of both the information seeker and the information mediator. To examine the dynamics of the information mediation process, an online diary survey was conducted in a real‐world workplace setting, followed by in‐depth interviews. This paper reports on a preliminary analysis of 450 diary entries in which participants reported the work tasks that required advice from colleagues as well as the extent of the advice provided. Analysis of the diary data revealed the types of tasks, types of advice, and relationship between task and advice types. The results suggest that people perceive tasks differently depending on whether they play the role of information seeker or information mediator, while their perception of advice seems to be independent of their role in the information mediation process. These typologies serve as a basis for further analyzing reciprocal influences between information seekers and mediators.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/96434/1/14504901263_ftp.pd

The Evaluation of the Body Weight Lowering Effects of Herbal Extract THI on Exercising Healthy Overweight Humans: A Randomized Double-Blind, Placebo-Controlled Trial

We investigated the effects of herbal extracts, a mixture of Scutellariae Radix and Platycodi Radix containing the active ingredients Baicalin and Saponin (target herbal ingredient (THI)), on lowering body weight. The present study was a prospective, randomized, double-blind, and placebo-controlled trial carried out at the outpatient department of a hospital over a period of 2 months. Group 1 patients (n=30) received THI, and group 2 patients (n=23) received placebo three times a day before meals. Weight, waist circumference, BMI, total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, and glucose were measured at baseline and again at the 2nd month. For safety evaluation, various hematological and biochemical parameters were assessed. Values of mean change of weight in the THI-treated group were −1.16±1.41 kg and in the placebo-treated group were −0.24±1.70 kg, respectively. The difference in mean change of weight in the THI-treated group compared with that in the placebo-treated group was statistically significant (P<0.05). The incidence of subjective and objective adverse drug reactions was insignificant (P>0.05). THI was statistically significant in its effectiveness on the weight loss

Structure of Osh3 Reveals a Conserved Mode of Phosphoinositide Binding in Oxysterol-Binding Proteins

SummaryThe oxysterol-binding protein (OSBP)-related proteins (ORPs) are conserved from yeast to humans, and implicated in the regulation of lipid homeostasis and in signaling pathways. Saccharomyces cerevisiae has seven ORPs (Osh1–Osh7) that share one unknown essential function. Here, we report the 1.5–2.3 Å structures of the PH domain and ORD (OSBP-related domain) of yeast Osh3 in apo-form or in complex with phosphatidylinositol 4-phosphate (PI[4]P). Osh3 recognizes PI(4)P by the highly conserved residues in the tunnel of ORD whereas it lacks sterol binding due to the narrow hydrophobic tunnel. Yeast complementation tests suggest that PI(4)P binding to PH and ORD is essential for function. This study suggests that the unifying feature in all ORP homologs is the binding of PI(4)P to ORD and sterol binding is additional to certain homologs. Structural modeling of full-length Osh3 is consistent with the concept that Osh3 is a lipid transfer protein or regulator in membrane contact sites

Investigation of the SH3BP2 Gene Mutation in Cherubism

Cherubism is a rare developmental lesion of the jaw that is generally inherited as an autosomal dominant trait. Recent studies have revealed point mutations in the SH3BP2 gene in cherubism patients. In this study, we examined a 6-year-old Korean boy and his family. We found a Pro418Arg mutation in the SH3BP2 gene of the patient and his mother. A father and his 30-month-old younger brother had no mutations. Immunohistochemically, the multinucleated giant cells proved positive for CD68 and tartrate-resistant acid phosphatase (TRAP). Numerous spindle-shaped stromal cells expressed a ligand for receptor activator of nuclear factor kB (RANKL), but not in multinucleated giant cells. These results provide evidence that RANKL plays a critical role in the differentiation of osteoclast precursor cells to multinucleated giant cells in cherubism. Additionally, genetic analysis may be a useful method for differentiation of cherubism.</p

Quasi-Eigenstate Evolution in Open Chaotic Billiards

We experimentally studied evolution of quasi-eigenmodes as classical dynamics undergoing a transition from being regular to chaotic in open quantum billiards. In a deformation-variable microcavity we traced all high-Q cavity modes in a wide range of frequency as the cavity deformation increased. By employing an internal parameter we were able to obtain a mode-dynamics diagram at a given deformation, showing avoided crossings between different mode groups, and could directly observe the coupling strengths induced by ray chaos among encountering modes. We also show that the observed mode-dynamics diagrams reflect the underlying classical ray dynamics in the phase space.Comment: 4 pages, 4 figure

A dyadic approach to information mediation at work: Examining credibility and value perceptions.

In daily interaction, workers play the dual role of information seekers and mediators by receiving or providing advice on how to find and use information. Using an online diary method, this study examines the dynamic and interactive process of information mediation focusing on (1) what factors influence how workers perceive the credibility of advice, (2) what factors influence how they perceive the value of the information mediation process, and (3) how their credibility perception impacts the value perception, depending on whether they receive or provide advice. The results show that, when receiving advice, credibility and value perceptions were almost exclusively influenced by the nature of the task for which the advice was needed. When providing advice, those perceptions were affected by more diverse factors including advice type and tenure. Furthermore, the relationship between credibility and value perceptions showed a marked difference depending on whether a person received or provided advice.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106412/1/Yang_Rieh_iConference2013.pd

Nutrigenomic Functions of PPARs in Obesogenic Environments

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that mediate the effects of several nutrients or drugs through transcriptional regulation of their target genes in obesogenic environments.This review consists of three parts. First, we summarize current knowledge regarding the role of PPARs in governing the development of white and brown/beige adipocytes from uncommitted progenitor cells. Next, we discuss the interactions of dietary bioactive molecules, such as fatty acids and phytochemicals, with PPARs for the modulation of PPAR-dependent transcriptional activities and metabolic consequences. Lastly, the effects of PPAR polymorphism on obesity and metabolic outcomes are discussed. In this review, we aim to highlight the critical role of PPARs in the modulation of adiposity and subsequent metabolic adaptation in response to dietary challenges and genetic modifications. Understanding the changes in obesogenic environments as a consequence of PPARs/nutrient interactions may help expand the field of individualized nutrition to prevent obesity and obesity-associated metabolic comorbidities

THE EFFECTS OF WEARING ROLLER SHOES ON MUSCLE ACTIVITY IN THE LOWER EXTREMITY DURING WALKING

Roller shoes have become increasingly popular among children and its features of retractable wheels which allow the user to walk or roll without changing the footwear. Maintaining balance during forward walking with roller shoes is not an easy task. To prevent falling backward, the user needs to lock the knees and tighten the ankles and thighs while the upper body is slightly leaning forward. Constant walking with roller shoes forces the user to walk in a manner much different from normal gait. Prolonged exposure to un-natural stresses on human body forces our body to evolve by strengthening those incorrect and temporary functions (Clement et al., 1981). For children, the chronic stress may lead to serious injuries in the lower extremity later in life. If any potential of injury exists in a movement it is critical to examine the associated muscle activity that may lead to injury. To the best of our knowledge, the effects of wearing roller shoes on muscle activity in the lower extremity have rarely been studied, especially in the youth population. Thus, the purpose of this study was to compare muscle activity in the lower extremity during walking wearing jogging and roller shoes