Blue Ocean Strategy vs. Competitive Strategy: The Effect of Business Strategic Choices on Firm Performance, According to the Industry Life Cycle

The purpose of this study is to explore how blue ocean strategy and competitive strategy influence a firm\u27s business performance differently according to its stage in the industry life cycle (ILC). We developed a theoretical research model and the measure items to capture the different attributes of the blue ocean and competitive paradigms. We collected primary data from 309 business owners and senior managers working in the U.S. through a survey research. We tested the data by performing the exploratory factor analysis (EFA), the confirmatory factor analysis (CFA) and the structural equation modeling analysis (SEM) using SPSS and AMOS. The results from the statistical analysis demonstrate that the effects of blue ocean strategy on a firm\u27s business performance become increasingly weak as ILC stages pass, while the effects of competitive strategy gradually strengthen. However, our results show that, in general, blue ocean strategy has a more positive effect on a firm\u27s performance than competitive strategy. In addition, the study results suggest that blue ocean strategy fully mediates the relationship between a firm\u27s market orientation and its business performance, while competitive strategy only partially mediates the relationship. We discuss some theoretical implications and contributions of our research findings

The Relationship between Metacognition, Entrepreneurial Orientation, and Firm Performance: An Empirical Investigation

This study aims to examine the relationship between an entrepreneur’s metacognition, entrepreneurial orientation (EO), and firm performance. We collected primary data from 190 entrepreneurs (business owners or founders) working in the U.S. through a survey. By performing both the confirmatory factor analysis (CFA) and the structural equation modeling (SEM), we tested our hypothesized research model that represented the metacognition-EO-firm performance relationship. The results from the statistical analysis demonstrate that an entrepreneur\u27s metacognition has a significant positive impact on EO. Furthermore, the study result shows that EO has a full mediating effect on the relationship between entrepreneurial metacognition and firm performance. We, thus, anticipate that the findings of this study will help entrepreneurs to understand the mechanism on how their metacognitions impact their business outcomes as well as to recognize why they should consider their metacognitive abilities while executing entrepreneurial tasks

Case of chronic indolent pheochromocytoma that caused medically controlled hypertension but treatment-resistant diabetes mellitus

No abstract available

The QM evolution: Behavioral quality management as a firm’s strategic resource

Firms implement various quality management (QM) practices to improve process quality. Scholars recognize that QM practices consist of both technical and behavioral oriented practices. The relationship of technical and behavioral oriented practices on performance has led to paradoxical relationships. Improving quality performance necessitates understanding the relationship between technical and behavioral orientated practices. This study empirically examines the relationship between technical and behavioral quality practices by collecting survey data from both US-based (N = 152) and China-based (N = 222) firms. The analysis uses the structural equation modeling technique, and shows that behavioral QM practices fully mediate the relationship between technical QM practices and firm performance. This implies that behavioral QM practices act as a strategic resource which helps generate a competitive advantage. The results contribute to understanding how quality management practices can lead to a competitive advantage

Comparison of the Plasma Metabolome Profiles Between the Internal Thoracic Artery and Ascending Aorta in Patients Undergoing Coronary Artery Bypass Graft Surgery Using Gas Chromatography Time-of-Flight Mass Spectrometry.

BackgroundThe left internal thoracic artery (LITA) has been used as the first conduit of choice in coronary artery bypass grafting (CABG) because of excellent long-term patency and outcomes. However, no studies have examined substances other than nitric oxide that could be beneficial for the bypass conduit, native coronary artery or ischemic myocardium. This study was conducted to evaluate differences in metabolic profiles between the LITA and ascending aorta using gas chromatography-time of flight-mass spectrometry (GC-TOF-MS).MethodsTwenty patients who underwent CABG using the LITA were prospectively enrolled. Plasma samples were collected simultaneously from the LITA and ascending aorta. GC-TOF-MS based untargeted metabolomic analyses were performed and a 2-step volcano plot analysis was used to identify distinguishable markers from two plasma metabolome profiles. Semi-quantitative and quantitative analyses were performed using GC-TOF-MS and enzyme-linked immunosorbent assay, respectively, after selecting target metabolites based on the metabolite set enrichment analysis.ResultsInitial volcano plot analysis demonstrated 5 possible markers among 851 peaks detected. The final analysis demonstrated that the L-cysteine peak was significantly higher in the LITA than in the ascending aorta (fold change = 1.86). The concentrations of intermediate metabolites such as L-cysteine, L-methionine and L-cystine in the 'cysteine and methionine metabolism pathway' were significantly higher in the LITA than in the ascending aorta (2.0-, 1.4- and 1.2-fold, respectively). Quantitative analysis showed that the concentration of hydrogen sulfide (H₂S) was significantly higher in the LITA.ConclusionThe plasma metabolome profiles of the LITA and ascending aorta were different, particularly higher plasma concentrations of L-cysteine and H₂S in the LITA

(E)-2,2′-[3-(2-Nitro­phen­yl)prop-2-ene-1,1-di­yl]bis­(3-hy­droxy­cyclo­hex-2-en-1-one)

In the title compound, C21H21NO6, each of the cyclo­hexenone rings adopts a half-chair conformation. Each of the pairs of hy­droxy and carbonyl O atoms are oriented to allow for the formation of intra­molecular O—H⋯O hydrogen bonds, which are typical of xanthene derivatives

Alpha-tocopherol exerts protective function against the mucotoxicity of particulate matter in amphibian and human goblet cells

Exposure to particulate matter (PM) in ambient air is known to increase the risk of cardiovascular disorders and mortality. The cytotoxicity of PM is mainly due to the abnormal increase of reactive oxygen species (ROS), which damage cellular components such as DNA, RNA, and proteins. The correlation between PM exposure and human disorders, including mortality, is based on long-term exposure. In this study we have investigated acute responses of mucus-secreting goblet cells upon exposure to PM derived from a heavy diesel engine. To this end, we employed the mucociliary epithelium of amphibian embryos and human Calu-3 cells to examine PM mucotoxicity. Our data suggest that acute exposure to PM significantly impairs mucus secretion and results in the accumulation of mucus vesicles in the cytoplasm of goblet cells. RNA-seq analysis revealed that acute responses to PM exposure significantly altered gene expression patterns; however, known regulators of mucus production and the secretory pathway were not significantly altered. Interestingly, pretreatment with alpha-tocopherol nearly recovered the hyposecretion of mucus from both amphibian and human goblet cells. We believe this study demonstrates the mucotoxicity of PM and the protective function of alpha-tocopherol on mucotoxicity caused by acute PM exposure from heavy diesel engines