自発的ドック受診者群と企業健診受診者群の脳MRIにおけるT2高信号域個数の比較

he purpose of this study was to evaluate the difference in T2-elongated spots (T2ES) between self-referred and third party-referred subjects.The brain MRI studies of 814 healthy adults were assessed. The subjects were categorized into two groups. Group A included 312 self-referred subjects ranging in age from 49 to 65 years (mean age, 56.5 years). Group B included 502 third party-referred subjects same ranging in age (mean age, 54.3 years). All subjects were asked to complete an interview sheet dealing with current and past diseases. To compare the two groups, an ‘Age-related Grading System\u27 was created.Grade 4 was defined as including patients who had 10 to 14 more T2ESs than their age minus 49; 20.027771275620f Group B and 13.51111400240f Group A (P<0.05) were classified as Grade 4. Diabetes mellitus was present in 15.016010062550f Group A and 9.615734071165f Group B (P<0.05). Hyperlipidemia was present in 18.015710062563f Group A and 9.015035020146f Group B (P<0.01).Although diabetes mellitus and hyperlipidemia were more common in Group A, these diseases were considered to be well controlled. It would appear that the patients in Group A were more health conscious than those in Group B

Additional file 1: Figure S1. of Within-pair differences of DNA methylation levels between monozygotic twins are different between male and female pairs

Within-pair differences for the methylation levels (WPDMs) of each CpG island. Red circles indicate male pairs, and blue circles indicate female pairs. Within-pair differences in male pairs are greater in most autosomal CpG islands. (TIF 2145 kb

Additional file 3: Figure S2. of Within-pair differences of DNA methylation levels between monozygotic twins are different between male and female pairs

Comparison of within-pair differences in methylation levels (WPDMs) between older male and older female pairs. The gender difference index is positive when the mean within-pair differences in the methylation levels are higher in male pairs than female pairs. (TIF 298 kb

Associations (expressed by regression coefficients with 95% CIs, BMI units (kg/m²)) of former smoking with BMI compared to current smokers (reference) in twin individuals (n = 156,593) and same-sex twin pairs (DZ or MZ pairs) discordant for their smoking status (m = 10,551 pairwise measurements) by sex and time period from the CODATwins database, 1960–2012.

<p>BMI = body mass index; CI = confidence interval; DZ = dizygotic; MZ = monozygotic.</p

Associations (expressed by regression coefficients with 95% CIs, BMI units (kg/m²)) of former smoking with BMI compared to never smokers (reference) in twin individuals (n = 156,593) and same-sex twin pairs (DZ or MZ pairs) discordant for their smoking status (m = 9,336 pairwise measurements) by sex and time period from the CODATwins database, 1960–2012.

<p>BMI = body mass index; CI = confidence interval; DZ = dizygotic; MZ = monozygotic.</p

Associations (expressed by regression coefficients with 95% CIs, BMI units (kg/m²)) of current smoking with BMI compared to never smokers (reference) in twin individuals (n = 156,593) and same-sex twin pairs (DZ or MZ pairs) discordant for their smoking status (m = 10,128 pairwise measurements) by sex and time period from the CODATwins database, 1960–2012.

<p>BMI = body mass index; CI = confidence interval; DZ = dizygotic; MZ = monozygotic.</p

Flow chart of the CODATwins dataset (n = 156,593 twin individuals and 30,014 pairwise comparisons in smoking discordant same-sexed twin pairs) included in the study.

<p>BMI = body mass index; MZ = monozygotic.</p