Incidence of Behçet’s disease by sex and age group from 2013 to 2014.

<p>Incidence of Behçet’s disease by sex and age group from 2013 to 2014.</p

Baseline characteristics of the study population.

<p>Baseline characteristics of the study population.</p

Flow chart of the study process.

<p>Flow chart of the study process.</p

Clinical risk stratification model for advanced colorectal neoplasia in persons with negative fecal immunochemical test results

<div><p>Objectives</p><p>The fecal immunochemical test (FIT) has low sensitivity for detecting advanced colorectal neoplasia (ACRN); thus, a considerable portion of FIT-negative persons may have ACRN. We aimed to develop a risk-scoring model for predicting ACRN in FIT-negative persons.</p><p>Materials and methods</p><p>We reviewed the records of participants aged ≥40 years who underwent a colonoscopy and FIT during a health check-up. We developed a risk-scoring model for predicting ACRN in FIT-negative persons.</p><p>Results</p><p>Of 11,873 FIT-negative participants, 255 (2.1%) had ACRN. On the basis of the multivariable logistic regression model, point scores were assigned as follows among FIT-negative persons: age (per year from 40 years old), 1 point; current smoker, 10 points; overweight, 5 points; obese, 7 points; hypertension, 6 points; old cerebrovascular attack (CVA), 15 points. Although the proportion of ACRN in FIT-negative persons increased as risk scores increased (from 0.6% in the group with 0–4 points to 8.1% in the group with 35–39 points), it was significantly lower than that in FIT-positive persons (14.9%). However, there was no statistical difference between the proportion of ACRN in FIT-negative persons with ≥40 points and in FIT-positive persons (10.5% vs. 14.9%, <i>P</i> = 0.321).</p><p>Conclusions</p><p>FIT-negative persons may need to undergo screening colonoscopy if they clinically have a high risk of ACRN. The scoring model based on age, smoking habits, overweight or obesity, hypertension, and old CVA may be useful in selecting and prioritizing FIT-negative persons for screening colonoscopy.</p></div

Point assignments for predicting advanced colorectal neoplasia in persons with negative fecal immunochemical test results.

<p>Point assignments for predicting advanced colorectal neoplasia in persons with negative fecal immunochemical test results.</p

Factors associated with advanced colorectal neoplasia according to the fecal immunochemical test results.

<p>Factors associated with advanced colorectal neoplasia according to the fecal immunochemical test results.</p

The number of persons and proportion of ACRN according to the risk scores in the FIT-negative group.

<p>Red bar graphs represent the number of persons in each risk group. Black points and bars represent the proportions of ACRN and their 95% confidence intervals. Statistical significance represents the difference in proportion of ACRN between each risk group and the FIT-positive group. ACRN, advanced colorectal neoplasia; FIT, fecal immunochemical test; NS, not significant. **<i>P</i> < 0.01, *<i>P</i> < 0.05.</p