The Idea of Compassion

The paper discusses the Buddhist notion of compassion through an analysis and critique of the Mahayana doctrines of bodhisattva (enlightened beings) and upaya (skillful means). While it recognizes the importance of the soteriological context of the concepts considered, it proposes both the possibility and necessity to look beyond this original meaning to one encompassing the social-historical dimension. It is only in this way can the notion of Buddhist compassion contribute to a discussion of salvation in the fullest sense of the word. The process thought influenced by A. N. Whitehead as well as the Liberal Protestant tradition have influenced the development of this discussion.大乗仏教の菩薩と方便の二つの概念の分析と批判的再考を通じて仏教の慈悲論を新たに考える。慈悲の救済論的意味を認識した上で新たなる慈悲の社会的歴史的側面の展開の可能性と必然性も認めなければならない。これによって初めて仏教の慈悲論は救済論の全ての側面について論ずることができる。ホワイトヘッド・プロセス思想とキリスト教自由神学の考えを参考しながらこの論点を展開す

Nonomuraea monospora sp. nov., an actinomycete isolated from cave soil in Thailand, and emended description of the genus Nonomuraea

A novel actinomycete, designated strain PT708T, was isolated from cave soil collected in Pha Tup Cave Forest Park, Nan province, Thailand. It produced compounds with antimicrobial and anticancer activities. Its chemotaxonomic properties were consistent with those of members of the genus Nonomuraea . The major menaquinone was MK-9(H4), with minor amounts of MK-9(H6), MK-9(H2), MK-10(H2) and MK-8(H4). The polar lipid profile contained phosphatidylmonomethylethanolamine, diphosphatidylglycerol, hydroxy-phosphatidylmonomethylethanolamine, hydroxy-phosphatidylethanolamine, phosphatidylethanolamine, phosphatidylglycerol, phosphatidylinositol mannoside and phosphatidylinositol. The major fatty acids were iso-C16 : 0, 10-methyl C17 : 0, C16 : 0 and C17 : 1ω6c. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain PT708T belonged to the genus Nonomuraea and was most closely related to Nonomuraea rhizophila YIM 67092T (98.50 % sequence similarity) and Nonomuraea rosea GW 12687T (98.30 %). The genomic DNA G+C content of strain PT708T was 73.3 mol%. Unlike the recognized members of the genus Nonomuraea , the novel strain formed single spores at the tips of aerial hyphae. Based on the phenotypic, phylogenetic and genotypic evidence, strain PT708T represents a novel species of the genus Nonomuraea , for which the name Nonomuraea monospora sp. nov. is proposed. The type strain is PT708T ( = TISTR 1910T = JCM 16114T)

Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease.

Cardiovascular dysautonomia as well as the deterioration of circadian rhythms are among the earliest detectable pathophysiological changes in individuals with Huntington's disease (HD). Preclinical research requires mouse models that recapitulate disease symptoms and the Q175 knock-in model offers a number of advantages but potential autonomic dysfunction has not been explored. In this study, we sought to test the dual hypotheses that cardiovascular dysautonomia can be detected early in disease progression in the Q175 model and that this dysfunction varies with the daily cycle. Using radiotelemetry implants, we observed a significant reduction in the diurnal and circadian activity rhythms in the Q175 mutants at the youngest ages. By middle age, the autonomically driven rhythms in core body temperature were highly compromised, and the Q175 mutants exhibited striking episodes of hypothermia that increased in frequency with mutant huntingtin gene dosage. In addition, Q175 mutants showed higher resting heart rate (HR) during sleep and greatly reduced correlation between activity and HR HR variability was reduced in the mutants in both time and frequency domains, providing more evidence of autonomic dysfunction. Measurement of the baroreceptor reflex revealed that the Q175 mutant could not appropriately increase HR in response to a pharmacologically induced decrease in blood pressure. Echocardiograms showed reduced ventricular mass and ejection fraction in mutant hearts. Finally, cardiac histopathology revealed localized points of fibrosis resembling those caused by myocardial infarction. Thus, the Q175 mouse model of HD exhibits cardiovascular dysautonomia similar to that seen in HD patients with prominent sympathetic dysfunction during the resting phase of the activity rhythm

Iwasawa N=8 Attractors

Starting from the symplectic construction of the Lie algebra e_7(7) due to Adams, we consider an Iwasawa parametrization of the coset E_7(7)/SU(8), which is the scalar manifold of N=8, d=4 supergravity. Our approach, and the manifest off-shell symmetry of the resulting symplectic frame, is determined by a non-compact Cartan subalgebra of the maximal subgroup SL(8,R) of E_7(7). In absence of gauging, we utilize the explicit expression of the Lie algebra to study the origin of E_7(7)/SU(8) as scalar configuration of a 1/8-BPS extremal black hole attractor. In such a framework, we highlight the action of a U(1) symmetry spanning the dyonic 1/8-BPS attractors. Within a suitable supersymmetry truncation allowing for the embedding of the Reissner-Nordstrom black hole, this U(1) is interpreted as nothing but the global R-symmetry of pure N=2 supergravity. Moreover, we find that the above mentioned U(1) symmetry is broken down to a discrete subgroup Z_4, implying that all 1/8-BPS Iwasawa attractors are non-dyonic near the origin of the scalar manifold. We can trace this phenomenon back to the fact that the Cartan subalgebra of SL(8,R) used in our construction endows the symplectic frame with a manifest off-shell covariance which is smaller than SL(8,R) itself. Thus, the consistence of the Adams-Iwasawa symplectic basis with the action of the U(1) symmetry gives rise to the observed Z_4 residual non-dyonic symmetry.Comment: 1+26 page

SHG microscopic observations of polar state in Li-doped KTaO3 under electric field

Incipient ferroelectric KTaO3 with off-center Li impurity of the critical concentration of 2.8 mol% was investigated in order to clarify the dipole glass state under electric field. Using optical second-harmonic generation (SHG) microscope, we observed a marked history dependence of SHG intensity through zero-field cooling (ZFC), zero-field heating (ZFH), field heating after ZFC (FH/ZFC) and FH after field cooling (FH/FC). These show different paths with respect to temperature: In the ZFC/ZFH process, weak SHG was observed at low temperature, while in the FH/ZFC process, relatively high SHG appears in a limited temperature range below TF depending on the field strength, and in the FC and FH/FC processes, the SHG exhibits ferroelectric-like temperature dependence: it appears at the freezing temperature of 50K, increases with decreasing temperature and has a tendency of saturation. These experimental results strongly suggest that dipole glass state or polar nano-clusters which gradually freezes with decreasing temperature is transformed into semi-macroscopic polar state under the electric field. However at sufficiently low temperature, the freezing is so strong that the electric field cannot enlarge the polar clusters. These experimental results show that the polar nano-cluster model similar to relaxors would be more relevant in KTaO3 doped with the critical concentration of Li. Further experiments on the anisotropy of SHG determine that the average symmetry of the field-induced polar phase is tetragonal 4mm or 4, which is also confirmed by the X-ray diffraction measurement.Comment: 26 pages, 8 figures, 1 tabl

Fast multipole networks

Two prerequisites for robotic multiagent systems are mobility and communication. Fast multipole networks (FMNs) enable both ends within a unified framework. FMNs can be organized very efficiently in a distributed way from local information and are ideally suited for motion planning using artificial potentials. We compare FMNs to conventional communication topologies, and find that FMNs offer competitive communication performance (including higher network efficiency per edge at marginal energy cost) in addition to advantages for mobility

Ovarian cancer has frequent loss of heterozygosity at chromosome 12p12.3-13.1 (region of TEL and Kip1 loci) and chromosome 12q23-ter: evidence for two new tumour-suppressor genes.

Identification of the key genetic alterations leading to ovarian cancer is in its infancy. Polymerase chain reaction (PCR)-based analysis of loss of heterozygosity (LOH) is a powerful method for detecting regions of altered tumour-suppressor genes. Focusing on chromosome 12, we examined 23 ovarian cancer samples for LOH using 31 highly polymorphic microsatellite markers and found the chromosomal localization of two putative tumour-suppressor genes. Two commonly deleted regions were 12p12.3-13.1 in 6/23 (26%) and 12q23-ter in 7/23 (30%) samples. LOH on chromosome 12 was more common in late-stage ovarian carcinomas. The region of LOH at 12p12.3-13.1 includes the genes that code for the ETS-family transcriptional factor, known as TEL, and the cyclin-dependent kinase inhibitor, known as p27Kip1. Mutational analysis of both TEL and p27Kip1 using single-strand conformation polymorphism (SSCP) showed no abnormalities, suggesting that the altered gene in this region is neither of these genes. Taken together, our data suggest that new tumour-suppressor genes in the region of chromosomes 12p12.3-13.1 and 12q23-ter may be involved in the development of ovarian cancer