Epigenomic marks indicating enhancer activity at the 5q22 locus.

<p>Histone marks in samples from the ROADMAP Epigenomics Project at the enhancer overlapping the lead SNP rs9885413 in heart tissue (left ventricle) and in tissues with evidence of an active enhancer at the locus. Histone marks are monomethylation (H3K4Me1) of the fourth residue (lysine) and acetylation of the 27th residue (H3K27Ac) of histone H3. Positions refer to NCBI build 36.</p

Association of genetic polymorphisms with HF mortality.

<p>Association of genetic polymorphisms with HF mortality.</p

Regional association plot for HF mortality at the 5q22 locus.

<p>The plot covers the genomic region from 450 kb upstream of the SNP to 650 kb downstream. Diamonds represent SNPs. The large black diamond represents the SNP with the lowest <i>P</i>-value (rs9885413), with the <i>P</i>-value from the combined meta-analysis presented. Diamond color represents strength of pairwise correlation with the strongest SNP. Red represents r² ≥ 0.8, orange represents r² 0.5–0.8, yellow represents r² 0.2–0.5, and white represents r² < 0.2. Recombination rate is plotted in the background and known genes are represented in the bottom of the plot. Positions refer to NCBI build 36. SNP correlations and recombination rates were obtained from HapMap release 22.</p

Characteristics of cohorts in stage 1.

<p>Characteristics of cohorts in stage 1.</p

Regional plots for the association of SNPs with MI in the region of <i>QKI</i>.

<p>Regional plots for the association of SNPs with MI in the region of <i>QKI</i>.</p

Association of the known SNPs for coronary artery disease with mortality after MI.

<p>Association of the known SNPs for coronary artery disease with mortality after MI.</p

Description and association of top SNPs with incident MI and CHD in Stage II and their combined results with Stage I.

<p>Description and association of top SNPs with incident MI and CHD in Stage II and their combined results with Stage I.</p

Study design for identification and validation of SNPs associated with MI and CHD.

<p>Study design for identification and validation of SNPs associated with MI and CHD.</p

Association of the known SNPs for coronary artery disease with incident MI and CHD in Stage I.

<p>Association of the known SNPs for coronary artery disease with incident MI and CHD in Stage I.</p