15 research outputs found

    The investigation of Toxoplasma gondii antibodies using IFA and IHA techniques in the patients with chronic renal failure

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    Purpose: Toxoplasmosis may be disseminated and fatal in immunocompromised and immunosuppressed person such as patients with malignancy and transplant patients. It can be transmitted with the transplanted organ to immunosuppressed recipient or may be due to reactivation under immunosuppression in case of pretransplant infection. Methods: In this study, Toxoplasma gondii antibodies were investigated using indirect fluorescent antibody (IFA) and indirect hemagglutination (IHA) techniques in 33 patients with chronic renal failure who might be candidates for renal transplantation in order to determine if they are a risk group for toxoplasmosis. In 20 healthy person who did not receive blood transfusion, the only indirect fluorescent antibody technique was used to search for Toxoplasma antibodies. Results: In the patients; the rate of total seropositivity was found to be 45% with indirect hemagglutination technique whereas the rate of IgG antibodies was 61% and the rate of IgM antibodies was 24% with indirect fluorescent antibody technique. However, in the control group, the rate of IgG antibodies was detected as 50%, whereas the rate of IgM antibodies was 5%. There was no statistically significant differences between the rates of IgG and IgM seropositivity in the patients and in the control groups (p = 0.07). Conclusion: Our findings suggest that Toxoplasma antibodies should be sought in hemodialysis patients and donors before transplantations in order to prevent the possibility of disseminated infection

    Wegener's granulomatosis complicated by pericardial tamponade and renal failure

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    WOS: A1996TU32200047PubMed ID: 8684561
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