L'Auto-vélo : automobilisme, cyclisme, athlétisme, yachting, aérostation, escrime, hippisme / dir. Henri Desgranges

02 novembre 19051905/11/02 (A6,N1844)

Additional file 3: of Transcriptome sequencing and analysis of zinc-uptake-related genes in Trichophyton mentagrophytes

The Nr, Swiss-Prot, KEGG and KOG annotation of unigenes. (XLSX 3000 kb

Additional file 9: of Transcriptome sequencing and analysis of zinc-uptake-related genes in Trichophyton mentagrophytes

Three pairs of primers that can amplify zinc-responsive. (DOCX 15 kb

Chronic obstructive pulmonary disease candidate gene prioritization based on metabolic networks and functional information

<div><p>Chronic obstructive pulmonary disease (COPD) is a multi-factor disease, in which metabolic disturbances played important roles. In this paper, functional information was integrated into a COPD-related metabolic network to assess similarity between genes. Then a gene prioritization method was applied to the COPD-related metabolic network to prioritize COPD candidate genes. The gene prioritization method was superior to ToppGene and ToppNet in both literature validation and functional enrichment analysis. Top-ranked genes prioritized from the metabolic perspective with functional information could promote the better understanding about the molecular mechanism of this disease. Top 100 genes might be potential markers for diagnostic and effective therapies.</p></div

Some of COPD-related KEGG pathways significantly enriched by top 100 genes.

<p>KEGG pathways (horizontal axis) were significantly enriched by top 100 genes (the number in the vertical axis) using DAVID (Benjamini corrected P value<0.05).</p

The retinol metabolism pathway and its top-ranked genes.

<p>Nodes with red name contain top 100 genes, whose ranks are listed in the right table. Nodes with purple border contain COPD-disease genes.</p

The ROC curves of our gene prioritization method, ToppGene and ToppNet.

<p>The ROC curves of our gene prioritization method, ToppGene and ToppNet.</p

Overlap of top 100 genes from our gene prioritization method, ToppGene and ToppNet, and their literature validation.

<p>Overlap of top 100 genes from our gene prioritization method, ToppGene and ToppNet, and their literature validation.</p

Top 100 genes and some of their enriched COPD-related functions or pathways.

<p>GO functions (green round rectangle) and KEGG pathways (blue parallelogram) were significantly enriched by top 100 genes (red ellipse) using DAVID (Benjamini corrected P value<0.05).</p

Some of COPD-related GO functions significantly enriched by top 100 genes.

<p>GO functions (horizontal axis) were significantly enriched by top 100 genes (the number in the vertical axis) using DAVID (Benjamini corrected P value<0.05).</p