4 research outputs found
Table1_Network meta-analysis of mineralocorticoid receptor antagonists for diabetic kidney disease.DOCX
Diabetic kidney disease (DKD) is one of the major causes of end-stage renal disease (ESRD). To evaluate the efficacy and safety of different types of mineralocorticoid receptor antagonists (MRAs) in diabetic kidney disease patients, we conducted this network meta-analysis by performing a systematic search in PubMed, MEDLINE, EMBASE, Web of Science, the Cochrane Library, and Clinicaltrials.gov. A total of 12 randomized clinical trials with 15,492 patients applying various types of MRAs covering spironolactone, eplerenone, finerenone, esaxerenone, and apararenone were included. The efficacy outcomes were the ratio of urine albumin creatine ratio (UACR) at posttreatment vs. at baseline, change in posttreatment estimated glomerular filtration (eGFR) vs. at baseline, and change in posttreatment systolic blood pressure (SBP) vs. at baseline. The safety outcome was the number of patients suffering from hyperkalemia. High-dose finerenone (MD −0.31, 95% CI: −0.52, −0.11), esaxerenone (MD −0.54, 95% CI: −0.72, −0.30), and apararenone (MD −0.63, 95% CI: −0.90, −0.35) were associated with a superior reduction in proteinuria in patients with DKD. Regarding the change in eGFR, the results of all drugs were similar, and finerenone may have potential superiority in protecting the kidney. Compared with placebo, none of the treatments was associated with a higher probability of controlling systolic blood pressure during treatment. Moreover, spironolactone, esaxerenone, and 20 mg of finerenone presented a higher risk of hyperkalemia. This Bayesian network meta-analysis was the first to explore the optimal alternative among MRAs in the treatment of DKD and revealed the superiority of 20 mg of finerenone among MRAs in treating DKD.Systematic Review Registration: PROSPERO, identifier (CRD42022313826)</p
High-Voltage Flexible Microsupercapacitors Based on Laser-Induced Graphene
High-voltage energy-storage
devices are quite commonly needed for
robots and dielectric elastomers. This paper presents a flexible high-voltage
microsupercapacitor (MSC) with a planar in-series architecture for
the first time based on laser-induced graphene. The high-voltage devices
are capable of supplying output voltages ranging from a few to thousands
of volts. The measured capacitances for the 1, 3, and 6 V MSCs were
60.5, 20.7, and 10.0 μF, respectively, under an applied current
of 1.0 μA. After the 5000-cycle charge–discharge test,
the 6 V MSC retained about 97.8% of the initial capacitance. It also
was recorded that the all-solid-state 209 V MSC could achieve a high
capacitance of 0.43 μF at a low applied current of 0.2 μA
and a capacitance of 0.18 μF even at a high applied current
of 5.0 μA. We further demonstrate the robust function of our
flexible high-voltage MSCs by using them to power a piezoresistive
microsensor (6 V) and a walking robot (>2000 V). Considering the
simple,
direct, and cost-effective fabrication method of our laser-fabricated
flexible high-voltage MSCs, this work paves the way and lays the foundation
for high-voltage energy-storage devices
High-Voltage Flexible Microsupercapacitors Based on Laser-Induced Graphene
High-voltage energy-storage
devices are quite commonly needed for
robots and dielectric elastomers. This paper presents a flexible high-voltage
microsupercapacitor (MSC) with a planar in-series architecture for
the first time based on laser-induced graphene. The high-voltage devices
are capable of supplying output voltages ranging from a few to thousands
of volts. The measured capacitances for the 1, 3, and 6 V MSCs were
60.5, 20.7, and 10.0 μF, respectively, under an applied current
of 1.0 μA. After the 5000-cycle charge–discharge test,
the 6 V MSC retained about 97.8% of the initial capacitance. It also
was recorded that the all-solid-state 209 V MSC could achieve a high
capacitance of 0.43 μF at a low applied current of 0.2 μA
and a capacitance of 0.18 μF even at a high applied current
of 5.0 μA. We further demonstrate the robust function of our
flexible high-voltage MSCs by using them to power a piezoresistive
microsensor (6 V) and a walking robot (>2000 V). Considering the
simple,
direct, and cost-effective fabrication method of our laser-fabricated
flexible high-voltage MSCs, this work paves the way and lays the foundation
for high-voltage energy-storage devices
High-Voltage Flexible Microsupercapacitors Based on Laser-Induced Graphene
High-voltage energy-storage
devices are quite commonly needed for
robots and dielectric elastomers. This paper presents a flexible high-voltage
microsupercapacitor (MSC) with a planar in-series architecture for
the first time based on laser-induced graphene. The high-voltage devices
are capable of supplying output voltages ranging from a few to thousands
of volts. The measured capacitances for the 1, 3, and 6 V MSCs were
60.5, 20.7, and 10.0 μF, respectively, under an applied current
of 1.0 μA. After the 5000-cycle charge–discharge test,
the 6 V MSC retained about 97.8% of the initial capacitance. It also
was recorded that the all-solid-state 209 V MSC could achieve a high
capacitance of 0.43 μF at a low applied current of 0.2 μA
and a capacitance of 0.18 μF even at a high applied current
of 5.0 μA. We further demonstrate the robust function of our
flexible high-voltage MSCs by using them to power a piezoresistive
microsensor (6 V) and a walking robot (>2000 V). Considering the
simple,
direct, and cost-effective fabrication method of our laser-fabricated
flexible high-voltage MSCs, this work paves the way and lays the foundation
for high-voltage energy-storage devices