Standard Model Higgs Searches at the LHC

An overview of the searches for the Standard Model Higgs boson at the LHC is presented. The main Higgs production and decay modes that have been studied are introduced, and the analysis techniques and the recent developments done by the ATLAS and CMS experiments are described. Some preliminary results from current studies are included. The discovery potential within the first few years of physics running is evaluated

Photolysis of an Amphiphilic Assembly by Calixarene-Induced Aggregation

Photosensitizers generally show great tendency for self-aggregation in aqueous media, leading to quenched fluorescence and lower photosensitizing ability. Herein, we report that amphiphilic anthracene is highly photoreactive after aggregation induced by <i>p</i>-sulfonatocalix­[4]­arene in water. The formation of a host–guest supramolecular assembly and the photolysis of the anthryl core are identified by UV–vis and NMR spectroscopy, dynamic light scattering, and transmission electron microscopy. Additionally, the assembly exhibited efficient photolysis with visible light in the presence of exogenous photosensitizers. This approach could be extended to various photoresponsive self-assemblies and applications in phototherapy and the design of photodegradable materials

Cholinesterase-Responsive Supramolecular Vesicle

Enzyme-responsive, amphiphilic self-assembly represents one of the increasingly significant topics in biomaterials research and finds feasible applications to the controlled release of therapeutic agents at specific sites where the target enzyme is located. The supramolecular approach, using “superamphiphiles”, provides a smart way to fabricate drug delivery systems responsive to enzymatic catalysis. In this work based on the concept of supramolecular chemistry, we report an enzyme-responsive vesicle using <i>p</i>-sulfonatocalix­[4]­arene as the macrocyclic host and natural enzyme-cleavable myristoylcholine as the guest molecule. The complexation of <i>p</i>-sulfonatocalix­[4]­arene with myristoylcholine directs the formation of a supramolecular binary vesicle, which is dissipated by cholinesterase with high specificity and efficiency. Cholinesterase is a key protein overexpressed in Alzheimer’s disease, and therefore, the present system may have potential for the delivery of Alzheimer’s disease drugs

Multifunctional Vehicle of Amphiphilic Calix[4]arene Mediated by Liposome

The fabrication of highly efficient nanovehicles represents one of the significant topics in biomedical and pharmaceutical fields. In this work, a perfect combination has been achieved between naturally occurring liposome and artificially macrocyclic receptor. Possessing long alkyl chains at lower rims, the amphiphilic <i>p</i>-sulfonatocalix­[4]­arenes (SC4As) can be readily embedded in the liposomal bilayers of zwitterionic phosphoglyceride, making the mixed liposomes a particularly appealing candidate for live cell imaging and targeted delivery. The obtained multifunctional vesicles possess several requisite characteristics for drug delivery purpose: (a) the negatively charged outer shell originating from SC4A that can lead to long-term colloidal stabilization in aqueous solution; (b) facile, nondestructive, noncovalent, and modular surface modification using specific host–guest interaction; (c) fluorescent imaging properties through the noncovalent linkage of fluorophores onto the lipid surface; and (d) surface decoration with biologically active ligands capable of specific targeting. Therefore, we believe that the unique structure and activity of self-assembled binary liposomes can be utilized to design smart multifunctional materials for wider application

Regulation of Stainless Steel Electrode Characteristics through Thermal Oxidation at Various Temperatures Induces Different Microbial Electrochemical Performances

The impact of thermal treatment at various temperatures on the properties of stainless steel (SS) anodes and subsequent bioelectricity generation is investigated in this study. It is observed that thermal oxidation at different temperatures significantly affects the characteristics of SS anodes. SS electrodes treated at 900 °C resulted in the best bioelectricity generation of Shewanella oneidensis MR-1 with a peak current density and power density of 0.36 ± 0.08 A m–2 and 1.15 ± 0.02 W m–2, respectively. Both experiments and molecular dynamics simulations indicate that such improvements may be due to not only the good biocompatibility of heat-treated SS electrodes but also the enhancement of direct extracellular electron transfer of S. oneidensis MR-1 to the anode. Moreover, using a home-made microfluidic device, we find that the biofilms on heat-treated SS electrodes exhibit better stability compared to unaltered ones. This study provides theoretical support for the application of SS electrodes in microbial electrochemistry technology

Discriminant Analysis for the Odor Identification Tests.

<p>Discriminant Analysis for the Odor Identification Tests.</p

Differentiation among HC, iRBD and PD patients by the brief test in validation.

<p>(A) Scatterplots of individual scores with the respective group median and 25th and 75th percentiles for the brief test in validation. (B) Receiver Operating Characteristic (ROC) curves showing the relationship between the sensitivity and specificity of the brief test in validation. ***<i>P</i><0.001, **<i>P</i><0.01</p

DATA (Olfactory Test in iRBD and PD).xlsx

<p>Odor identification was evaluated in iRBD patients (n=54), PD patients (n=54) and healthy controls (n=54) in China. With the identification data, a brief odor identification test was established and then validated in other subjects.</p

Patient Demographics in the Validation Test.

<p>Patient Demographics in the Validation Test.</p

Differentiation among HC, iRBD and PD patients by the odor identification tests.

<p>(A) Scatterplots of individual scores with the respective group median and 25th and 75th percentiles for the Sniffin’ Sticks. (B) Receiver Operating Characteristic (ROC) curves showing the relationship between sensitivity and specificity of the Sniffin’ Sticks (dotted lines) and the brief test (solid lines). ***<i>P</i><0.001</p