Risks of postoperative adverse events associated with preoperative characteristics of myasthenia gravis.

<p>Risks of postoperative adverse events associated with preoperative characteristics of myasthenia gravis.</p

Graphical summary of genome-wide association analysis for TRS in a Han Chinese population.

<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033598#s2" target="_blank">Results</a> (−log₁₀<i>P</i>) are shown in chromosomal order for 694,436 SNPs which were tested in 522 cases and 806 controls by using Affymetrix SNP 6.0 Array. The horizontal line indicates a <i>P</i>-value of 10⁻⁵.</p

Refined regional association plots.

<p>For each plot of the four clusters ((A) <i>SLAMF1</i>, (B) <i>NFKB1</i>, (C) <i>DOCK4</i>, and (D) <i>RIPK4</i>), the −log₁₀<i>P</i> values for the trend test from Affymetrix SNP 6.0 Array in 522 cases and 806 controls are plotted as red diamond according to their genomic position (NCBI Build 36.3). The SNPs with the strongest signal are represented as blue diamonds. The recombination rates (right y-axis) based on the Chinese HapMap population is plotted as green lines to reflect the local LD structure around the SNPs. The dashed horizontal line indicates a <i>P</i>-value of 10⁻⁵.</p

Results of GWAS for TRS in Han population.

<p>SNP position were indexed to the forward of NCBI Build 36.3.</p><p>ch: chromosome.</p><p>RA: Risk allele, the allele with higher frequency in schizophrenia as compared with controls;</p><p>RAF: risk allele frequency.</p><p>F: frequency.</p><p><i>P</i>_trend: P values obtained from the initial GWA analysis on 522 cases and 806 controls.</p><p><i>P</i>_joint: P values calculated from joint analysis on 804 cases and 806 controls.</p><p>OR, odds ratio for risk allele.</p

Variants identified in NFKB1 by direct sequencing in 94 TRS cases and controls.

<p>Risk allele means the allele with higher frequency in schizophrenia as compared with controls;</p><p>RAF: risk allele frequency.</p><p>P: promoter, I : intron.</p

Demographic and clinical characteristics for TRS.

#<p>means the body-mass index is the weight in kilograms divided by the square of the height in meters.</p>∧<p>means more than 5 years of persistence of illness without period of good social or occupational functioning assayed by the severity of illness subscale of clinical global impression (CGI-S).</p

LD plot of rs28362491 (-94delATTG).

<p>rs28362491 shows linkage disequilibrium with the Affymetrix SNPs. Both rs230529 and rs4699030 have the lowest <i>P</i> value in this study.</p

Reporter assay of rs28362491 (-94ins/delATTG) of <i>NFKB1</i> in SH-SY5Y cells.

<p>pGL3 luciferase reporter contained either the -94ATTGATTG (W) or the -94ATTG (D) allele at the promoter region of the <i>NFKB1</i>. Values represented the average of three experiments and the error bars represented the standard deviation. pGL3-basic was used as control without any promoter sequence inserted. ** <i>P</i><0.01.</p