4 research outputs found
Additional file 3: of Can statistic adjustment of OR minimize the potential confounding bias for meta-analysis of case-control study? A secondary data analysis
Summary of included original study. (PDF 1 mb
Additional file 1: of Can statistic adjustment of OR minimize the potential confounding bias for meta-analysis of case-control study? A secondary data analysis
Search strategy. (PDF 86 kb
Nanoplatform Assembled from a CD44-Targeted Prodrug and Smart Liposomes for Dual Targeting of Tumor Microenvironment and Cancer Cells
The tumor microenvironment (TME)
plays a critical role in tumor initiation, progression, invasion,
and metastasis. Therefore, a therapy that combines chemotherapeutic
drugs with a TME modulator could be a promising route for cancer treatment.
This paper reports a nanoplatform self-assembled from a hyaluronic
acid (HA)-paclitaxel (PTX) (HA-PTX) prodrug and marimastat (MATT)-loaded
thermosensitive liposomes (LTSLs) (MATT-LTSLs) for the dual targeting
of the TME and cancer cells. Interestingly, the prodrug HA-PTX can
self-assemble on both positively and negatively charged liposomes,
forming hybrid nanoparticles (HNPs, 100 nm). Triggered by mild hyperthermia,
HA-PTX/MATT-LTSLs HNPs rapidly release their payloads into the extracellular
environment, and the released HA-PTX quickly enters 4T1 cells through
a CD44-HA affinity. The HNPs possess promoted tumor accumulation (1.6-fold),
exhibit deep tumor penetration, and significantly inhibit the tumor
growth (10-fold), metastasis (100%), and angiogenesis (10-fold). Importantly,
by targeting the TME and maintaining its integrity <i>via</i> inhibiting the expression and activity of matrix metalloproteinases
(>5-fold), blocking the fibroblast activation by downregulating
the TGF-β1 expression (5-fold) and suppressing the degradation
of extracellular matrix, the HNPs allow for significant metastasis
inhibition. Overall, these findings indicate that a prodrug of an
HA–hydrophobic-active compound and liposomes can be self-assembled
into a smart nanoplatform for the dual targeting of the TME and tumor
cells and efficient combined treatment; additionally, the co-delivery
of MATT and HA-PTX with the HNPs is a promising approach for the treatment
of metastatic cancer. This study creates opportunities for fabricating
multifunctional nanodevices and offers an efficient strategy for disease
therapy
Nanoplatform Assembled from a CD44-Targeted Prodrug and Smart Liposomes for Dual Targeting of Tumor Microenvironment and Cancer Cells
The tumor microenvironment (TME)
plays a critical role in tumor initiation, progression, invasion,
and metastasis. Therefore, a therapy that combines chemotherapeutic
drugs with a TME modulator could be a promising route for cancer treatment.
This paper reports a nanoplatform self-assembled from a hyaluronic
acid (HA)-paclitaxel (PTX) (HA-PTX) prodrug and marimastat (MATT)-loaded
thermosensitive liposomes (LTSLs) (MATT-LTSLs) for the dual targeting
of the TME and cancer cells. Interestingly, the prodrug HA-PTX can
self-assemble on both positively and negatively charged liposomes,
forming hybrid nanoparticles (HNPs, 100 nm). Triggered by mild hyperthermia,
HA-PTX/MATT-LTSLs HNPs rapidly release their payloads into the extracellular
environment, and the released HA-PTX quickly enters 4T1 cells through
a CD44-HA affinity. The HNPs possess promoted tumor accumulation (1.6-fold),
exhibit deep tumor penetration, and significantly inhibit the tumor
growth (10-fold), metastasis (100%), and angiogenesis (10-fold). Importantly,
by targeting the TME and maintaining its integrity <i>via</i> inhibiting the expression and activity of matrix metalloproteinases
(>5-fold), blocking the fibroblast activation by downregulating
the TGF-β1 expression (5-fold) and suppressing the degradation
of extracellular matrix, the HNPs allow for significant metastasis
inhibition. Overall, these findings indicate that a prodrug of an
HA–hydrophobic-active compound and liposomes can be self-assembled
into a smart nanoplatform for the dual targeting of the TME and tumor
cells and efficient combined treatment; additionally, the co-delivery
of MATT and HA-PTX with the HNPs is a promising approach for the treatment
of metastatic cancer. This study creates opportunities for fabricating
multifunctional nanodevices and offers an efficient strategy for disease
therapy