412 research outputs found
Second-order accurate genuine BGK schemes for the ultra-relativistic flow simulations
This paper presents second-order accurate genuine BGK (Bhatnagar-Gross-Krook)
schemes in the framework of finite volume method for the ultra-relativistic
flows. Different from the existing kinetic flux-vector splitting (KFVS) or
BGK-type schemes for the ultra-relativistic Euler equations, the present
genuine BGK schemes are derived from the analytical solution of the
Anderson-Witting model, which is given for the first time and includes the
"genuine" particle collisions in the gas transport process. The BGK schemes for
the ultra-relativistic viscous flows are also developed and two examples of
ultra-relativistic viscous flow are designed. Several 1D and 2D numerical
experiments are conducted to demonstrate that the proposed BGK schemes not only
are accurate and stable in simulating ultra-relativistic inviscid and viscous
flows, but also have higher resolution at the contact discontinuity than the
KFVS or BGK-type schemes.Comment: 41 pages, 13 figure
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Characterization of Laser-Resistant Port Wine Stain Blood Vessels Using In Vivo Reflectance Confocal Microscopy.
Background and objectivesPort wine stain (PWS) is a congenital vascular malformation of the human skin. Laser is the treatment of choice for PWS. Laser-resistant PWS is one crucial factor accounting for inadequate treatment outcome, which needs to be fully characterized. This study aims to quantitatively characterize the morphology of laser-resistant PWS blood vessels in the upper papillary dermis using in vivo reflectance confocal microscopy (RCM).Study design/materials and methodsA total of 42 PWS subjects receiving laser treatment from August 2016 through July 2018 were enrolled into this study. Thirty-three subjects had facial PWS; nine had extremity PWS. All subject's PWS received multiplex 585/1,064 nm laser treatment. RCM images were taken before and after treatment. The density, diameter, blood flow, and depth of PWS blood vessels were analyzed.ResultsWe found 44.4% PWS on the extremities (four out of nine subjects) were laser-resistant, which was significantly higher (P < 0.001) when compared with those PWS on the face (15.2%, 5 out of 33 subjects). The laser-resistant facial PWS blood vessels had significantly higher blood flow (1.35 ± 0.26 U vs. 0.89 ± 0.22 U, P < 0.001), larger blood vessel diameters (109.60 ± 18.24 µm vs. 84.36 ± 24.04 µm, P = 0.033) and were located deeper in the skin (106.01 ± 13.87 µm vs. 87.82 ± 12.57 µm, P < 0.001) in the skin when compared with laser-responsive PWS on the face. The average PWS blood vessel density (17.01 ± 4.63/mm2 vs. 16.61 ± 4.44/mm2 , P = 0.857) was not correlated to the laser resistance.ConclusionsLaser-resistant PWS blood vessels had significantly higher blood flow, larger diameters, and were located deeper in the skin. RCM can be a valuable tool for a prognostic evaluation on laser-resistant lesions before treatment, thereby providing guidance for tailored laser treatment protocols, which may improve the therapeutic outcome. The limitations for this study include relative small sample size and acquisitions of different blood vessels before and after 2 months of treatment. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc
Infer Implicit Contexts in Real-time Online-to-Offline Recommendation
Understanding users' context is essential for successful recommendations,
especially for Online-to-Offline (O2O) recommendation, such as Yelp, Groupon,
and Koubei. Different from traditional recommendation where individual
preference is mostly static, O2O recommendation should be dynamic to capture
variation of users' purposes across time and location. However, precisely
inferring users' real-time contexts information, especially those implicit
ones, is extremely difficult, and it is a central challenge for O2O
recommendation. In this paper, we propose a new approach, called Mixture
Attentional Constrained Denoise AutoEncoder (MACDAE), to infer implicit
contexts and consequently, to improve the quality of real-time O2O
recommendation. In MACDAE, we first leverage the interaction among users,
items, and explicit contexts to infer users' implicit contexts, then combine
the learned implicit-context representation into an end-to-end model to make
the recommendation. MACDAE works quite well in the real system. We conducted
both offline and online evaluations of the proposed approach. Experiments on
several real-world datasets (Yelp, Dianping, and Koubei) show our approach
could achieve significant improvements over state-of-the-arts. Furthermore,
online A/B test suggests a 2.9% increase for click-through rate and 5.6%
improvement for conversion rate in real-world traffic. Our model has been
deployed in the product of "Guess You Like" recommendation in Koubei.Comment: 9 pages,KDD,KDD201
Complete Genome and Transcriptomes of Streptococcus parasanguinis FW213: Phylogenic Relations and Potential Virulence Mechanisms
Streptococcus parasanguinis, a primary colonizer of the tooth surface, is also an opportunistic pathogen for subacute endocarditis. The complete genome of strain FW213 was determined using the traditional shotgun sequencing approach and further refined by the transcriptomes of cells in early exponential and early stationary growth phases in this study. The transcriptomes also discovered 10 transcripts encoding known hypothetical proteins, one pseudogene, five transcripts matched to the Rfam and additional 87 putative small RNAs within the intergenic regions defined by the GLIMMER analysis. The genome contains five acquired genomic islands (GIs) encoding proteins which potentially contribute to the overall pathogenic capacity and fitness of this microbe. The differential expression of the GIs and various open reading frames outside the GIs at the two growth phases suggested that FW213 possess a range of mechanisms to avoid host immune clearance, to colonize host tissues, to survive within oral biofilms and to overcome various environmental insults. Furthermore, the comparative genome analysis of five S. parasanguinis strains indicates that albeit S. parasanguinis strains are highly conserved, variations in the genome content exist. These variations may reflect differences in pathogenic potential between the strains
Study on the Comprehensive Properties and Microstructures of A3-3 Matrix Graphite Related to the High Temperature Purification Treatment
At the beginning, a comparative analysis was made on the oxidation corrosion rate and ash content of A3-3 matrix graphite (MG) pebbles lathed before and after high temperature purification (HTP) treatment. Their oxidation corrosion rate and ash contents were almost identical, which indicated that the HTP process was to purify the entire MG pebbles and not limited on the surfaces. Furthermore, the multiple mechanical and thermal properties of MG treated without and with the treatment of HTP at ~1900°C were compared and their microstructure features were characterized as well. As the crush strength, oxidation corrosion rate, and erosion rate of MG without HTP treatment did not satisfy the specifications, the comprehensive properties and purity of MG with HTP were improved in various degrees through the HTP process so that all performances met the requirements of the A3-3 MG. The improvement of crush strength and erosion rate of MG in the HTP process could be mainly attributed to the upgradation of ordered microstructure and corresponding increase of density. However, the enhancement of oxidation corrosion rate was due to the synergistic effects of microstructural optimization and reduction of impurity elements, especially the transition metal elements of MG in the HTP process
A Sialidase‐Deficient Porphyromonas gingivalis Mutant Strain Induces Less Interleukin‐1β and Tumor Necrosis Factor‐α in Epi4 Cells Than W83 Strain Through Regulation of c‐Jun N‐Terminal Kinase Pathway
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142178/1/jpere129.pd
Numerical modelling of buried pipelines under DC stray current corrosion
Corrosion of buried pipelines caused by stray currents is becoming a serious industrial and environmental problem. It is therefore necessary to study corrosion mechanisms of buried pipelines under DC stray currents in order to propose effective anti-corrosion measures. Since measurement of the potential is one of important ways to identify stray current intensity, the COMSOL Multiphysics software was used to simulate stray current corrosion dynamics of buried pipelines. It was also used to calculate the distribution and intensity changes of electrolyte potential in the cathodic protected system by solving Laplace’s three-dimensional equation. The obtained results showed that increased applied voltage leads to more positive shift of a pipeline potential, resulting in acceleration of stray current corrosion. On the contrary, increased soil resistivity can retard the corrosion process. The protected pipeline with a sacrificial anode suffers less corrosion interference than unprotected pipeline. Two crossed arrangement of pipelines makes no difference in corrosion of protected pipeline, but affects greatly on unprotected pipeline
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