Identification of RCT abstracts from the Chinese Biomedical Database.

<p>Identification of RCT abstracts from the Chinese Biomedical Database.</p

Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis

The piericidin A1 (<b>1</b>) gene cluster was identified from the deep-sea derived <i>Streptomyces</i> sp. SCSIO 03032. Our in vivo and in vitro experiments verified PieE as a 4′-hydroxylase and PieB2 as a 4′-<i>O</i>-methyltransferase, allowing the elucidation of the post-PKS modification steps involved in <b>1</b> biosynthesis. In addition, the shunt metabolite piericidin E1 (<b>7</b>) was identified as a novel analogue featuring a C-2/C-3 epoxy ring

Number of abstracts identified and included from five Chinese medical journals.

<p>Data of impact factor and total citations are from the China Journal Citation Reports (CJCR) in 2007.</p

Additional file 2: of Methodology and reporting quality of reporting guidelines: systematic review

Detailed information of the included reporting guidelines. The information of the included reporting guidelines, including publication date, scope, focus, areas, version, and other relevant details. (PDF 161 kb

Additional file 1: of Methodology and reporting quality of reporting guidelines: systematic review

Search strategies.(PDF 75 kb

Additional file 3: of Methodology and reporting quality of reporting guidelines: systematic review

The PRISMA checklist with the page number where each item is reported. (PDF 204 kb

Additional file 1 of Validity and usability testing of a health systems guidance appraisal tool, the AGREE-HS

AGREE-HS Reporting Checklist. (DOCX 683 kb

Additional file 2 of Validity and usability testing of a health systems guidance appraisal tool, the AGREE-HS

AGREE-HS item information. (DOCX 23 kb

Heronamides D–F, Polyketide Macrolactams from the Deep-Sea-Derived <i>Streptomyces</i> sp. SCSIO 03032

Three new macrolactams, heronamides D–F (<b>1</b>–<b>3</b>), were isolated from the deep-sea-derived <i>Streptomyces</i> sp. SCSIO 03032 upon changing cultivation conditions. The planar structures of heronamides D–F (<b>1</b>–<b>3</b>) were elucidated by extensive MS and NMR spectroscopic analyses and comparisons with the closely related heronamides A–C. The relative configurations of <b>1</b>–<b>3</b> were deduced by detailed analysis of ³<i>J</i>_HH values and NOESY data. The absolute configurations of <b>1</b> and <b>2</b> were determined by chemical modifications and application of the modified Mosher’s method. None of the compounds exhibited obvious antimicrobial or cytotoxic activities

Additional file 1 of Facilitators, barriers and strategies for health-system guidance implementation: a critical interpretive synthesis protocol

Additional file 1. PRISMA-P 2015 checklist