Clerodane Diterpenoids from <i>Croton crassifolius</i>

Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay

Clerodane Diterpenoids from <i>Croton crassifolius</i>

Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay

Clerodane Diterpenoids from <i>Croton crassifolius</i>

Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay

Clerodane Diterpenoids from <i>Croton crassifolius</i>

Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay

Clerodane Diterpenoids from <i>Croton crassifolius</i>

Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay

Three new diterpenoids from <i>Croton laui</i> Merr. et Metc

<p>Three new diterpenoids, including one labdane diterpenoid (<b>1</b>) and two cembrane diterpenoids (<b>2</b>–<b>3</b>), were isolated from the aerial parts of <i>Croton laui</i>, along with four known analogues (<b>4</b>–<b>7</b>). Their structures were elucidated by spectroscopic analysis and comparison with literature data. All compounds were evaluated for their cytotoxicity against two tumour cell lines.</p

Four Matrine-Based Alkaloids with Antiviral Activities against HBV from the Seeds of Sophora alopecuroides

Four novel matrine-based alkaloids (<b>1</b>–<b>4</b>) were isolated from the seeds of Sophora alopecuroides. Compounds <b>1</b> and <b>2</b> possess unprecedented 6/6/6/4 and 6/5/6/6 ring systems, respectively, while <b>3</b> and <b>4</b> are a pair of stereoisomeric matrine–acetophenone alkaloids with an unusual skeleton. Their structures were elucidated by means of spectroscopic methods and single-crystal X-ray diffraction. Hypothetical biogenetic pathways for <b>1</b>–<b>4</b> are proposed, and their antiviral activities are also discussed

Dimeric Matrine-Type Alkaloids from the Roots of <i>Sophora flavescens</i> and Their Anti-Hepatitis B Virus Activities

Six unusual matrine-type alkaloid dimers, flavesines A–F (<b>1–6</b>, respectively), together with three proposed biosynthetic intermediates (<b>7–9</b>) were isolated from the roots of <i>Sophora flavescens</i>. Compounds <b>1–5</b> were the first natural matrine-type alkaloid dimers, and compound <b>6</b> represented an unprecedented dimerization pattern constructed by matrine and (−)-cytisine. Their structures were elucidated by NMR, MS, single-crystal X-ray diffraction, and a chemical method. The hypothetical biogenetic pathways of <b>1–6</b> were also proposed. Compounds <b>1–9</b> exhibited inhibitory activities against hepatitis B virus

Drychampones A–C: Three Meroterpenoids from <i>Dryopteris championii</i>

Three novel sesquiterpenoid-based meroterpenoids, drychampones A–C (<b>1</b>–<b>3</b>, respectively), were isolated from <i>Dryopteris championii</i>. Compounds <b>1</b> and <b>3</b> possessed a novel carbon skeleton which was constructed by an 11/6/6 ring system coupled with a pyronone moiety, and <b>1</b>–<b>3</b> were three racemates. Their structures and absolute configurations were elucidated by NMR, MS, and computational methods. The hypothetical biosynthetic pathways of these meroterpenoids and their antibacterial activities were also discussed

Cajanusflavanols A–C, Three Pairs of Flavonostilbene Enantiomers from <i>Cajanus cajan</i>

Three pairs of new flavonostilbene enantiomers, cajanusflavanols A–C (<b>1</b>–<b>3</b>), along with their putative biogenetic precursors <b>4</b>–<b>6</b>, were isolated from <i>Cajanus cajan.</i> Compound <b>1</b> possesses an unprecedented carbon skeleton featuring a unique highly functionalized cyclopenta­[1,2,3-<i>de</i>]­isobenzopyran-1-one tricyclic core. Compounds <b>2</b> and <b>3</b> are the first examples of methylene-unit-linked flavonostilbenes. Their structures with absolute configurations were elucidated by spectroscopic analyses, X-ray diffraction, and computational calculations. Compounds <b>1</b> and <b>2</b> exhibited significant <i>in vitro</i> anti-inflammatory activities