21 research outputs found
Clerodane Diterpenoids from <i>Croton crassifolius</i>
Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated
by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D
NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray
diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex
virus type 1 using the cytopathic effect reduction assay
Clerodane Diterpenoids from <i>Croton crassifolius</i>
Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated
by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D
NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray
diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex
virus type 1 using the cytopathic effect reduction assay
Clerodane Diterpenoids from <i>Croton crassifolius</i>
Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated
by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D
NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray
diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex
virus type 1 using the cytopathic effect reduction assay
Clerodane Diterpenoids from <i>Croton crassifolius</i>
Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated
by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D
NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray
diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex
virus type 1 using the cytopathic effect reduction assay
Clerodane Diterpenoids from <i>Croton crassifolius</i>
Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated
by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D
NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray
diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex
virus type 1 using the cytopathic effect reduction assay
Three new diterpenoids from <i>Croton laui</i> Merr. et Metc
<p>Three new diterpenoids, including one labdane diterpenoid (<b>1</b>) and two cembrane diterpenoids (<b>2</b>–<b>3</b>), were isolated from the aerial parts of <i>Croton laui</i>, along with four known analogues (<b>4</b>–<b>7</b>). Their structures were elucidated by spectroscopic analysis and comparison with literature data. All compounds were evaluated for their cytotoxicity against two tumour cell lines.</p
Four Matrine-Based Alkaloids with Antiviral Activities against HBV from the Seeds of Sophora alopecuroides
Four
novel matrine-based alkaloids (<b>1</b>–<b>4</b>) were isolated from the seeds of Sophora
alopecuroides. Compounds <b>1</b> and <b>2</b> possess unprecedented 6/6/6/4 and 6/5/6/6 ring systems,
respectively, while <b>3</b> and <b>4</b> are a pair of
stereoisomeric matrine–acetophenone alkaloids with an unusual
skeleton. Their structures were elucidated by means of spectroscopic
methods and single-crystal X-ray diffraction. Hypothetical biogenetic
pathways for <b>1</b>–<b>4</b> are proposed, and
their antiviral activities are also discussed
Dimeric Matrine-Type Alkaloids from the Roots of <i>Sophora flavescens</i> and Their Anti-Hepatitis B Virus Activities
Six unusual matrine-type
alkaloid dimers, flavesines A–F
(<b>1–6</b>, respectively), together with three proposed
biosynthetic intermediates (<b>7–9</b>) were isolated
from the roots of <i>Sophora flavescens</i>. Compounds <b>1–5</b> were the first natural matrine-type alkaloid dimers,
and compound <b>6</b> represented an unprecedented dimerization
pattern constructed by matrine and (−)-cytisine. Their structures
were elucidated by NMR, MS, single-crystal X-ray diffraction, and
a chemical method. The hypothetical biogenetic pathways of <b>1–6</b> were also proposed. Compounds <b>1–9</b> exhibited
inhibitory activities against hepatitis B virus
Drychampones A–C: Three Meroterpenoids from <i>Dryopteris championii</i>
Three novel sesquiterpenoid-based
meroterpenoids, drychampones
A–C (<b>1</b>–<b>3</b>, respectively), were
isolated from <i>Dryopteris championii</i>. Compounds <b>1</b> and <b>3</b> possessed a novel carbon skeleton which
was constructed by an 11/6/6 ring system coupled with a pyronone moiety,
and <b>1</b>–<b>3</b> were three racemates. Their
structures and absolute configurations were elucidated by NMR, MS,
and computational methods. The hypothetical biosynthetic pathways
of these meroterpenoids and their antibacterial activities were also
discussed
Cajanusflavanols A–C, Three Pairs of Flavonostilbene Enantiomers from <i>Cajanus cajan</i>
Three pairs of new flavonostilbene
enantiomers, cajanusflavanols
A–C (<b>1</b>–<b>3</b>), along with their
putative biogenetic precursors <b>4</b>–<b>6</b>, were isolated from <i>Cajanus cajan.</i> Compound <b>1</b> possesses an unprecedented carbon skeleton featuring a unique
highly functionalized cyclopentaÂ[1,2,3-<i>de</i>]Âisobenzopyran-1-one
tricyclic core. Compounds <b>2</b> and <b>3</b> are the
first examples of methylene-unit-linked flavonostilbenes. Their structures
with absolute configurations were elucidated by spectroscopic analyses,
X-ray diffraction, and computational calculations. Compounds <b>1</b> and <b>2</b> exhibited significant <i>in vitro</i> anti-inflammatory activities