学会抄録

Risk of bias. (TIF 107 kb

Microdeletions at DYS448 and DYS387S1 associate with increased risk of male infertility

<p>Male infertility affects many people of reproductive age. Diagnosis and therapies based on descriptive semen parameters have helped some of the infertility patients; however, further progress in reproductive therapy demands a better understanding of the molecular and genetic causes for male infertility. Although Y chromosome microdeletions have been a hot subject of genetic studies on male infertility, the relationship between male infertility and microdeletions at Y chromosome loci DYS448, DYS387, and DYS627 remains unclear. Here we analyzed the microdeletions at these three loci in 200 infertility male patients and 200 healthy subjects and showed that microdeletions at DYS448 and DYS387 correlate with male infertility. Our results suggest that genetic analyses of Y chromosome loci DYS448 and DYS387 can be genetic markers for reproductive diagnosis and therapy.</p

Diagnostic Performance of Magnifying Endoscopy for <i>Helicobacter pylori</i> Infection: A Meta-Analysis

<div><p>Background</p><p>Diagnosis of <i>Helicobacter pylori</i> (<i>H</i>. <i>pylori</i>) infection using magnifying endoscopy offers advantages over conventional invasive and noninvasive tests.</p><p>Objective</p><p>This meta-analysis aimed to assess the diagnostic performance of magnifying endoscopy in the prediction of <i>H</i>. <i>pylori</i> infection.</p><p>Methods</p><p>A literature search of the PubMed, Medline, EMBASE, Science Direct and the Cochrane Library databases was performed. A random-effects model was used to calculate the diagnostic efficiency of magnifying endoscopy for <i>H</i>. <i>pylori</i> infection. A summary receiver operator characteristic curve was plotted, and the area under the curve (AUC) was calculated.</p><p>Results</p><p>A total of 18 studies involving 1897 patients were included. The pooled sensitivity and specificity of magnifying endoscopy to predict <i>H</i>. <i>pylori</i> infection were 0.89 [95% confidence interval (CI) 0.87–0.91] and 0.82 (95%CI 0.79–0.85), respectively, with an AUC of 0.9461. When targeting the gastric antrum, the pooled sensitivity and specificity were 0.82 (95%CI 0.78–0.86) and 0.72 (95%CI 0.66–0.78), respectively. When targeting the gastric corpus, the pooled sensitivity and specificity were 0.92 (95%CI 0.90–0.94) and 0.86 (95%CI 0.82–0.88), respectively. The pooled sensitivity and specificity using magnifying white light endoscopy were 0.90 (95%CI 0.87–0.91) and 0.81 (95%CI 0.77–0.84), respectively. The pooled sensitivity and specificity using magnifying chromoendoscopy were 0.87 (95%CI 0.83–0.91) and 0.85 (95%CI 0.80–0.88), respectively. The “pit plus vascular pattern” classification in the gastric corpus observed by magnifying endoscopy was able to accurately predict the status of <i>H</i>. <i>pylori</i> infection, as indicated by a pooled sensitivity and specificity of 0.96 (95%CI 0.94–0.97) and 0.91 (95%CI 0.87–0.93), respectively, with an AUC of 0.9872.</p><p>Conclusions</p><p>Magnifying endoscopy was able to accurately predict the status of <i>H</i>. <i>pylori</i> infection, either in magnifying white light endoscopy or magnifying chromoendoscopy mode. The “pit plus vascular pattern” classification in the gastric corpus is an optimum diagnostic criterion.</p></div

The diagnostic performance of magnifying endoscopy in predicting <i>H</i>. <i>pylori</i> infection.

<p>(A), pooled sensitivity; (B), pooled specificity; (C), summary receiver operating characteristic curve for diagnosis by magnifying endoscopy. CI, confidence interval; AUC, area under the curve; SE, standard error.</p

The diagnostic performance of a “pit plus vascular pattern” classification in the gastric corpus by magnifying endoscopy in predicting <i>H</i>. <i>pylori</i> infection.

<p>(A), pooled sensitivity; (B), pooled specificity; (C), summary receiver operating characteristic curve for diagnosis by magnifying endoscopy. CI, confidence interval; AUC, area under the curve; SE, standard error.</p

Deeks’ funnel plot to evaluate publication bias.

<p><i>P</i> = 0.83 indicates a symmetrical funnel shape and suggests that publication bias is absent.</p

Flow diagram of the study selection process for the meta-analysis.

<p>Finally, 18 studies were identified from the 12 articles.</p

Diagnostic performance of magnifying endoscopy for <i>H</i>. <i>pylori</i> infection.

<p>Diagnostic performance of magnifying endoscopy for <i>H</i>. <i>pylori</i> infection.</p

Proportion of studies with low, high, or unclear risk of bias, %.

<p>Proportion of studies with low, high, or unclear risk of bias, %.</p

Proportion of studies with low, high, or unclear concerns regarding applicability, %.

<p>Proportion of studies with low, high, or unclear concerns regarding applicability, %.</p