Undergraduate theses in Zoological Laboratory, Hiroshima University (1932-1953) <Data>

広島大学前身校の一つである広島文理科大学は,東京文理科大学と同様,主として中等学校教員の養成を主要な目的として設立された「旧二文理大」の一つである。広島文理科大学動物学教室における1932 年(昭和7 年)の第1 回卒業生から1953 年(昭和28 年)の最後の卒業生までの卒業者約120 名について,卒業論文と指導教官を整理し,一覧表を作成した。これに基づき,広島文理科大学動物学教室における教育研究の変遷,及び現在の広島大学における動物学研究との関連などについて考察した

First Detection of Near-Infrared Intraday Variations in the Seyfert 1 Nucleus NGC4395

We carried out a one-night optical V and near-infrared JHK monitoring observation of the least luminous Seyfert 1 galaxy, NGC4395, on 2004 May 1, and detected for the first time the intraday flux variations in the J and H bands, while such variation was not clearly seen for the K band. The detected J and H variations are synchronized with the flux variation in the V band, which indicates that the intraday-variable component of near-infrared continuum emission of the NGC4395 nucleus is an extension of power-law continuum emission to the near-infrared and originates in an outer region of the central accretion disk. On the other hand, from our regular program of long-term optical BVI and near-infrared JHK monitoring observation of NGC4395 from 2004 February 12 until 2005 January 22, we found large flux variations in all the bands on time scales of days to months. The optical BVI variations are almost synchronized with each other, but not completely with the near-infrared JHK variations. The color temperature of the near-infrared variable component is estimated to be T=1320-1710 K, in agreement with thermal emission from hot dust tori in active galactic nuclei (AGNs). We therefore conclude that the near-infrared variation consists of two components having different time scales, so that a small K-flux variation on a time scale of a few hours would possibly be veiled by large variation of thermal dust emission on a time scale of days.Comment: 4 pages including figures, accepted for publication in ApJ

Limnotrachelobdella okae (Hirudinida, Piscicolidae) from Cherry Salmon Oncorhynchus masou masou in Neritic Deep Waters of the Western North Pacific Ocean

The piscicolid leech Limnotrachelobdella okae (Moore, 1924) was found attached to the skin near the pectoral fin of a cherry salmon Oncorhynchus masou masou caught at a depth of 180-200 m in the western North Pacific Ocean off the east coast of northern Honshu, Japan. This is the first record of L. okae from the ocean-swimming salmonid in neritic deep waters although it is not known where the fish was infected. L. okae has been generally believed to be a parasite of both marine and freshwater fishes, but it is concluded, based on the present results and the literature review on the host and distributional records, that the leech is a coastal marine or brackish-water species: the infection occurs only in salt waters, and anadromous fishes, such as salmonids, carry the leech to fresh waters, where it can survive for a certain period

VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid–liquid phase separation

Myofibroblasts cause tissue fibrosis by producing extracellular matrix proteins, such as collagens. Humoral factors like TGF-β, and matrix stiffness are important for collagen production by myofibroblasts. However, the molecular mechanisms regulating their ability to produce collagen remain poorly characterised. Here, we show that vestigial-like family member 3 (VGLL3) is specifically expressed in myofibroblasts from mouse and human fibrotic hearts and promotes collagen production. Further, substrate stiffness triggers VGLL3 translocation into the nucleus through the integrin β1-Rho-actin pathway. In the nucleus, VGLL3 undergoes liquid-liquid phase separation via its low-complexity domain and is incorporated into non-paraspeckle NONO condensates containing EWS RNA-binding protein 1 (EWSR1). VGLL3 binds EWSR1 and suppresses miR-29b, which targets collagen mRNA. Consistently, cardiac fibrosis after myocardial infarction is significantly attenuated in Vgll3-deficient mice, with increased miR-29b expression. Overall, our results reveal an unrecognised VGLL3-mediated pathway that controls myofibroblasts’ collagen production, representing a novel therapeutic target for tissue fibrosis

Multiple Regression Analysis of the Variable Component in the Near-Infrared Region for Type 1 AGN MCG+08-11-011

We propose a new method of analysing a variable component for type 1 active galactic nuclei (AGNs) in the near-infrared wavelength region. This analysis uses a multiple regression technique and divides the variable component into two components originating in the accretion disk at the center of AGNs and from the dust torus that far surrounds the disk. Applying this analysis to the long-term $VHK$ monitoring data of MCG+08-11-011 that were obtained by the MAGNUM project, we found that the $(H-K)$-color temperature of the dust component is $T = 1635$K $\pm20$K, which agrees with the sublimation temperature of dust grains, and that the time delay of $K$ to $H$ variations is $\Delta t\approx 6$ days, which indicates the existence of a radial temperature gradient in the dust torus. As for the disk component, we found that the power-law spectrum of $f_\nu \propto \nu^\alpha$ in the $V$ to near-infrared $HK$ bands varies with a fixed index of $\alpha\approx -0.1$ -- +0.4, which is broadly consistent with the irradiated standard disk model. The outer part of the disk therefore extends out to a radial distance where the temperature decreases to radiate the light in the near-infrared.Comment: 10pages + 5figures, accepted by ApJ

Description of three new bat-associated species of hard ticks (Acari, Ixodidae) from Japan

In Eurasia, the geographically most widespread ixodid tick species of the bat families Rhinolophidae Gray, Vespertilionidae Gray, and Miniopteridae Dobson were considered to belong to four species, Ixodes vespertilionis Koch, I. collaris Hornok, I. ariadnae Hornok, and I. simplex Neumann. Previous data attest that bat-associated tick species from Eastern Asia show remarkable genetic difference from the above four tick species, but in the absence of detailed morphological comparison these were regarded as conspecific. In this study we compensate for this lack of data on three bat-associated tick species, reporting their morphological comparison, as well as molecular and phylogenetic relationships. According to the results we describe the females of three tick species new to science, i.e., I. nipponrhinolophi Hornok &amp;amp; Takano, sp. nov., I. fuliginosus Hornok &amp;amp; Takano, sp. nov., and I. fujitai Hornok &amp;amp; Takano, sp. nov. In case of all three new tick species the cytochrome c oxidase subunit (coxI) gene showed remarkably high sequence differences from the species that they previously were thought to belong to, well exceeding the average limit delineating ixodid tick species. This, as well as observed morphological differences fully justify their taxonomical status as new species

High degree of mitochondrial gene heterogeneity in the bat tick species Ixodes vespertilionis, I. ariadnae and I. simplex from Eurasia

Background: Phylogeographical studies allow precise genetic comparison of specimens, which were collected over large geographical ranges and belong to the same or closely related animal species. These methods have also been used to compare ticks of veterinary-medical importance. However, relevant data are missing in the case of ixodid ticks of bats, despite (1) the vast geographical range of both Ixodes vespertilionis and Ixodes simplex, and (2) the considerable uncertainty in their taxonomy, which is currently unresolvable by morphological clues. Methods: In the present study 21 ticks were selected from collections or were freshly removed from bats or cave walls in six European and four Asian countries. The DNA was extracted and PCRs were performed to amplify part of the cytochrome oxidase I (COI), 16S and 12S rDNA genes, followed by sequencing for identification and molecular-phylogenetic comparison. Results: No morphological differences were observed between Ixodes vespertilionis specimens from Spain and from other parts of Europe, but corresponding genotypes had only 94.6 % COI sequence identity. An I. vespertilionis specimen collected in Vietnam was different both morphologically and genetically (i.e. with only 84.1 % COI sequence identity in comparison with I. vespertilionis from Europe). Two ticks (collected in Vietnam and in Japan) formed a monophyletic clade and shared morphological features with I. ariadnae, recently described and hitherto only reported in Europe. In addition, two Asiatic specimens of I. simplex were shown to differ markedly from European genotypes of the same species. Phylogenetic relationships of ticks showed similar clustering patterns with those of their associated bat host species. Conclusions: Although all three ixodid bat tick species evaluated in the present study appear to be widespread in Eurasia, they exhibit pronounced genetic differences. Data of this study also reflect that I. vespertilionis may represent a species complex

Elevated Levels of Serum Pentosidine Are Associated with Dropped Head Syndrome in Older Women

Study Design A retrospective observational study was performed. Purpose We investigated the prevalence of sarcopenia in dropped head syndrome (DHS), and the relationship between biochemical markers, including major advanced glycation end products (AGEs), pentosidine, and DHS in older women. Overview of Literature AGEs have been implicated in the pathogenesis of sarcopenia. Methods We studied 13 elderly women with idiopathic DHS (mean age, 77.2 years) and 20 healthy volunteers (mean age, 74.8 years). We used a bioelectrical impedance analyzer to analyze body composition, including appendicular skeletal muscle mass index (SMI; appendicular lean mass [kg]/[height (m)]2). Cervical sagittal plane alignment, including C2–C7 sagittal vertical axis (C2–C7SVA), C2–C7 angle, and C2 slope (C2S), was measured. Biochemical markers, such as serum and urinary pentosidine, serum homocysteine, 1, 25-dihydroxyvitamin D, and 25-hydroxyvitamin D, were measured. The level of each variable was compared between DHS and controls. The relationship between biochemical markers and DHS was examined. Results Sarcopenia (SMI <5.75) was observed at a high prevalence in participants with DHS (77% compared to 22% of healthy controls). Height, weight, femoral bone mineral density, appendicular lean mass, total lean mass, and SMI all had significantly lower values in the DHS group. Serum and urinary pentosidine, and serum homocysteine were significantly higher in the DHS group compared to controls. Analysis of cervical alignment revealed a significant positive correlation of serum pentosidine with C2–C7SVA and C2S. Conclusions Sarcopenia was involved in DHS, and high serum pentosidine levels are associated with severity of DHS in older women