Theory of proximity effect in ferromagnet/superconductor heterostructures in the presence of spin dependent interfacial phase shift

We study the proximity effect and charge transport in ferromagnet (F)/superconductor (S) and S/F/I/F/S junctions (where I is insulator) by taking into account simultaneously exchange field in F and spin-dependent interfacial phase shifts (SDIPS) at the F/S interface. We solve the Usadel equations using extended Kupriyanov–Lukichev boundary conditions which include SDIPS, where spin-independent part of tunneling conductance GT and spin-dependent one Gφ coexist. The resulting local density of states (LDOS) in a ferromagnet depends both on the exchange energy Eex and Gφ/GT. We show that the magnitude of zero-temperature gap and the height of zero-energy LDOS have a non-monotonic dependence on Gφ/GT. We also calculate Josephson current in S/F/I/F/S junctions and show that crossover from 0-state to

Non-Universal Power Law of the "Hall Scattering Rate" in a Single-Layer Cuprate Bi_{2}Sr_{2-x}La_{x}CuO_{6}

In-plane resistivity \rho_{ab}, Hall coefficient, and magnetoresistance (MR) are measured in a series of high-quality Bi_{2}Sr_{2-x}La_{x}CuO_{6} crystals with various carrier concentrations, from underdope to overdope. Our crystals show the highest T_c (33 K) and the smallest residual resistivity ever reported for Bi-2201 at optimum doping. It is found that the temperature dependence of the Hall angle obeys a power law T^n with n systematically decreasing with increasing doping, which questions the universality of the Fermi-liquid-like T^2 dependence of the "Hall scattering rate". In particular, the Hall angle of the optimally-doped sample changes as T^{1.7}, not as T^2, while \rho_{ab} shows a good T-linear behavior. The systematics of the MR indicates an increasing role of spin scattering in underdoped samples.Comment: 4 pages, 5 figure

Prebiotic Organic Microstructures

Micro- and sub-micrometer spheres, tubules and fiber-filament soft structures have been synthesized in our experiments conducted with 3 MeV proton irradiations of a mixture of simple inorganic constituents, CO, N2 and H2O. We analysed the irradiation products, with scanning electron microscopy (SEM) and atomic force microscopy (AFM). These laboratory organic structures produced wide variety of proteinous and non-proteinous amino acids after HCl hydrolysis. The enantiomer analysis for D-, L- alanine confirmed that the amino acids were abiotically synthesized during the laboratory experiment. Considering hydrothermal activity, the presence of CO2 and H2, of a ferromagnesian silicate mineral environment, of an Earth magnetic field which was much less intense during Archean times than nowadays and consequently of a proton excitation source which was much more abundant, we propose that our laboratory organic microstructures might be synthesized during Archean times. We show similarities in morphology and in formation with some terrestrial Archean microstructures and we suggest that some of the observed Archean carbon spherical and filamentous microstructures might be composed of abiogenic organic molecules. We further propose a search for such prebiotic organic signatures on Mars. This article has been posted on Nature precedings on 21 July 2010 [1]. Extinct radionuclides as source of excitation have been replaced by cosmic radiations which were much more intense 3.5 Ga ago because of a much less intense Earth magnetic field. The new version of the article has been presented at the ORIGINS conference in Montpellier in july 2011 [2] and has since been published in Origins of Life and Evolution of Biospheres 42 (4) 307-316, 2012. 
DOI: 10.1007/s11084-012-9290-5 

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Linear approaches to intramolecular Förster Resonance Energy Transfer probe measurements for quantitative modeling

Numerous unimolecular, genetically-encoded Forster Resonance Energy Transfer (FRET) probes for monitoring biochemical activities in live cells have been developed over the past decade. As these probes allow for collection of high frequency, spatially resolved data on signaling events in live cells and tissues, they are an attractive technology for obtaining data to develop quantitative, mathematical models of spatiotemporal signaling dynamics. However, to be useful for such purposes the observed FRET from such probes should be related to a biological quantity of interest through a defined mathematical relationship, which is straightforward when this relationship is linear, and can be difficult otherwise. First, we show that only in rare circumstances is the observed FRET linearly proportional to a biochemical activity. Therefore in most cases FRET measurements should only be compared either to explicitly modeled probes or to concentrations of products of the biochemical activity, but not to activities themselves. Importantly, we find that FRET measured by standard intensity-based, ratiometric methods is inherently non-linear with respect to the fraction of probes undergoing FRET. Alternatively, we find that quantifying FRET either via (1) fluorescence lifetime imaging (FLIM) or (2) ratiometric methods where the donor emission intensity is divided by the directly-excited acceptor emission intensity (denoted R<sub>alt</sub>) is linear with respect to the fraction of probes undergoing FRET. This linearity property allows one to calculate the fraction of active probes based on the FRET measurement. Thus, our results suggest that either FLIM or ratiometric methods based on R<sub>alt</sub> are the preferred techniques for obtaining quantitative data from FRET probe experiments for mathematical modeling purpose

The role of AmeloD in tooth development

The development of ectodermal organs, such as teeth, requires epithelial–mesenchymal interactions. Basic helix–loop–helix (bHLH) transcription factors regulate various aspects of tissue development, and we have previously identified a bHLH transcription factor, AmeloD, from a tooth germ cDNA library. Here, we provide both in vitro and in vivo evidence that AmeloD is important in tooth development. We created AmeloD-knockout (KO) mice to identify the in vivo functions of AmeloD that are critical for tooth morphogenesis. We found that AmeloD-KO mice developed enamel hypoplasia and small teeth because of increased expression of E-cadherin in inner enamel epithelial (IEE) cells, and it may cause inhibition of the cell migration. We used the CLDE dental epithelial cell line to conduct further mechanistic analyses to determine whether AmeloD overexpression in CLDE cells suppresses E-cadherin expression and promotes cell migration. Knockout of epiprofin (Epfn), another transcription factor required for tooth morphogenesis and development, and analysis of AmeloD expression and deletion revealed that AmeloD also contributed to multiple tooth formation in Epfn-KO mice by promoting the invasion of dental epithelial cells into the mesenchymal region. Thus, AmeloD appears to play an important role in tooth morphogenesis by modulating E-cadherin and dental epithelial–mesenchymal interactions. These findings provide detailed insights into the mechanism of ectodermal organ development

Epstein-Barr Virus latent membrane protein 1 induces Snail and epithelial–mesenchymal transition in metastatic nasopharyngeal carcinoma

Background:Epstein-Barr Virus (EBV)-associated nasopharyngeal carcinoma (NPC) is distinctive among head-and-neck cancers in its undifferentiated histopathology and highly metastatic character. We have recently investigated the involvement of epithelial–mesenchymal transition (EMT) in NPC. In a previous study, we found a close association of expression of LMP1, the principal EBV oncoprotein, with expression of Twist and induction of EMT.Methods:We analysed expression of Snail in 41 NPC tissues by immunohistochemistry. The role of Twist as well as Snail in EMT of NPC was investigated by using NP69SV40T human nasopharyngeal cells.Results:In NPC tissues, overexpression of Snail is associated with expression of LMP1 in carcinomatous cells. In addition, expression of Snail positively correlated with metastasis and independently correlated inversely with expression of E-cadherin. Expression of Twist had no association with expression of E-cadherin. Further, in a human nasopharyngeal cell line, LMP1 induces EMT and its associated cellular motility and invasiveness. Expression of Snail is induced by LMP1 in these cells, and small hairpin RNA (shRNA) to Snail reversed the cellular changes. By contrast, Twist did not produce EMT in these nasopharyngeal cells.Conclusions:This study strengthens the association of EMT with the metastatic behaviour of NPC. These results suggest that induction of Snail by the EBV oncoprotein LMP1 has a pivotal role in EMT in NPC

TcT_c suppression in co-doped striped cuprates

We propose a model that explains the reduction of $T_c$ due to the pinning of stripes by planar impurity co-doping in cuprates. A geometrical argument about the planar fraction of carriers affected by stripe pinning leads to a a linear $T_c$ suppression as a function of impurity concentration $z$. The critical value $z_c$ for the vanishing of superconductivity is shown to scale like $T_c^2$ in the under-doped regime and becomes universal in the optimally- and over-doped regimes. Our theory agrees very well with the experimental data in single- and bi-layer cuprates co-doped with Zn, Li, Co, etc...Comment: 4 pages, 4 figure

Nature of the Electronic Excitations near the Brillouin Zone Boundary of Bi2_2Sr2_2CaCu2_2O8+δ_{8+\delta}

Based on angle resolved photoemission spectra measured on different systems at different dopings, momenta and photon energies, we show that the anomalously large spectral linewidth in the $(\pi,0)$ region of optimal doped and underdoped Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$ has significant contributions from the bilayer splitting, and that the scattering rate in this region is considerably smaller than previously estimated. This new picture of the electronic excitation near $(\pi,0)$ puts additional experimental constraints on various microscopic theories and data analysis.Comment: 5 pages, 4 figure