The bursting, spiking and silent cell types.

<p>The bursting, spiking and silent cell types.</p

Cell labeling in a HCP cluster of <i>n</i> = 4.

<p>Cell labeling in a HCP cluster of <i>n</i> = 4.</p

SCP and HCP β-cell clusters.

<p>In a 2D cluster <i>n</i>_c = 4 for SCP (a) and <i>n</i>_c = 6 for HCP (b). In 3D the numbers become <i>n</i>_c = 6 for SCP (c) and <i>n</i>_c = 12 for HCP (d).</p

Heterogeneity in parameter values.

<p>Heterogeneity in parameter values.</p

Parameters and their values.

<p>Parameters and their values.</p

Threshold of β-cell loss that would lead to complete loss of bursting synchronization.

<p>Threshold of β-cell loss that would lead to complete loss of bursting synchronization.</p

Rates of BMI SDS above 85th (overweight & obese) percentiles for each 5-year period (1995–1999 and 2000–2004) by age.

<p>Incidence calculated by using yearly U.S census data for 8 county metro area <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0006873#pone.0006873-3" target="_blank">[35]</a>.</p

Number of trait-relevant pathways in each of the eight animal groups.

<p>Number of trait-relevant pathways in each of the eight animal groups.</p

Pathway composition of the top 2 densely connected subregions of the whole trait-pathway network.

<p>Pathway composition of the top 2 densely connected subregions of the whole trait-pathway network.</p

Scheme of cell labeling in an HCP β-cell cluster.

<p>Scheme of cell labeling in an HCP β-cell cluster.</p