2 research outputs found
Design, synthesis, and biological evaluation of piperazine derivatives involved in the 5-HT<sub>1A</sub>R/BDNF/PKA pathway
In this study, four series of piperazine derivatives were designed, synthesised and subjected to biological test, and compound 6a with potential antidepressant activity was obtained. An affinity assay of compound 6a with 5-hydroxytryptamine (serotonin, 5-HT)1A receptor (5-HT1AR) was undertaken, and the effects on the 5-HT level in the brains of mice were also tested. The results showed that compound 6a had the best affinity with 5-HT1AR (Ki = 1.28 nM) and significantly increased the 5-HT level. The expression levels of 5-HT1AR, BDNF, and PKA in the hippocampus were analysed by western blot and immunohistochemistry analyses. The results showed that the expression of 5-HT1AR, BDNF, and PKA in the model group was reduced compared to that of the control group, and compound 6a could reverse this phenomenon. Molecular docking was performed to investigate the interactions of the studied compound 6a with 5-HT1AR on the molecular level. </p
Copper Doped Hollow Structured Manganese Oxide Mesocrystals with Controlled Phase Structure and Morphology as Anode Materials for Lithium Ion Battery with Improved Electrochemical Performance
We develop a facile
synthesis route to prepare Cu doped hollow structured manganese oxide
mesocrystals with controlled phase structure and morphology using
manganese carbonate as the reactant template. It is shown that Cu
dopant is homogeneously distributed among the hollow manganese oxide
microspherical samples, and it is embedded in the lattice of manganese
oxide by substituting Mn<sup>3+</sup> in the presence of Cu<sup>2+</sup>. The crystal structure of manganese oxide products can be modulated
to bixbyite Mn<sub>2</sub>O<sub>3</sub> and tetragonal Mn<sub>3</sub>O<sub>4</sub> in the presence of annealing gas of air and nitrogen,
respectively. The incorporation of Cu into Mn<sub>2</sub>O<sub>3</sub> and Mn<sub>3</sub>O<sub>4</sub> induces a great microstructure evolution
from core–shell structure for pure Mn<sub>2</sub>O<sub>3</sub> and Mn<sub>3</sub>O<sub>4</sub> samples to hollow porous spherical
Cu-doped Mn<sub>2</sub>O<sub>3</sub> and Mn<sub>3</sub>O<sub>4</sub> samples with a larger surface area, respectively. The Cu-doped hollow
spherical Mn<sub>2</sub>O<sub>3</sub> sample displays a higher specific
capacity of 642 mAhg<sup>–1</sup> at a current density of 100
mA g<sup>–1</sup> after 100 cycles, which is about 1.78 times
improvement compared to that of 361 mA h g<sup>–1</sup> for
the pure Mn<sub>2</sub>O<sub>3</sub> sample, displaying a Coulombic
efficiency of up to 99.5%. The great enhancement of the electrochemical
lithium storage performance can be attributed to the improvement of
the electronic conductivity and lithium diffusivity of electrodes.
The present results have verified the ability of Cu doping to improve
electrochemical lithium storage performances of manganese oxides