Data_Sheet_2_The increased functional connectivity between the locus coeruleus and supramarginal gyrus in insomnia disorder with acupuncture modulation.PDF

BackgroundInsomnia disorder (ID) seriously affects the quality of people’s daily life, and acupuncture is an effective therapy for it. As an essential component of the upward activation system, the locus coeruleus (LC) plays a crucial role in sleep–wake regulation, its aberrant functional connectivity (FC) is found to be involved in ID. The purpose of this study was to explore the modulation effect of acupuncture on the resting state FC of LC in ID patients.Methods60 ID patients were recruited and randomly assigned to real acupuncture (RA) or sham acupuncture (SA) treatment. Resting-state functional magnetic resonance imaging (fMRI) data were collected before and after the treatment. With LC as the region of interest, the FC method was adopted to examine acupuncture-related modulation of intrinsic connectivity in ID patients. The Pittsburgh Sleep Quality Index (PSQI), Hyperarousal Scale (HAS), and actigraphy were used to assess sleep quality and cortical hyperarousal states. Associations between clinical outcomes and FC features were calculated using Pearson’s correlation analysis.ResultsThe improvement in sleep quality and hyperarousal in the RA group was greater than that in the SA group. After treatment, the FC between the LC and left inferior frontal gyrus (IFG) decreased in the RA group. The FC between the LC and left insula and supramarginal gyrus (SMG) was higher in the RA group. The change of LC FC values with the SMG was negatively associated with the change in PSQI scores.ConclusionAcupuncture can modulate FC between the LC and IFG, insular gyrus, and SMG. This may imply the potential mechanism of acupuncture treatment for insomnia.</p

Data_Sheet_1_The increased functional connectivity between the locus coeruleus and supramarginal gyrus in insomnia disorder with acupuncture modulation.PDF

BackgroundInsomnia disorder (ID) seriously affects the quality of people’s daily life, and acupuncture is an effective therapy for it. As an essential component of the upward activation system, the locus coeruleus (LC) plays a crucial role in sleep–wake regulation, its aberrant functional connectivity (FC) is found to be involved in ID. The purpose of this study was to explore the modulation effect of acupuncture on the resting state FC of LC in ID patients.Methods60 ID patients were recruited and randomly assigned to real acupuncture (RA) or sham acupuncture (SA) treatment. Resting-state functional magnetic resonance imaging (fMRI) data were collected before and after the treatment. With LC as the region of interest, the FC method was adopted to examine acupuncture-related modulation of intrinsic connectivity in ID patients. The Pittsburgh Sleep Quality Index (PSQI), Hyperarousal Scale (HAS), and actigraphy were used to assess sleep quality and cortical hyperarousal states. Associations between clinical outcomes and FC features were calculated using Pearson’s correlation analysis.ResultsThe improvement in sleep quality and hyperarousal in the RA group was greater than that in the SA group. After treatment, the FC between the LC and left inferior frontal gyrus (IFG) decreased in the RA group. The FC between the LC and left insula and supramarginal gyrus (SMG) was higher in the RA group. The change of LC FC values with the SMG was negatively associated with the change in PSQI scores.ConclusionAcupuncture can modulate FC between the LC and IFG, insular gyrus, and SMG. This may imply the potential mechanism of acupuncture treatment for insomnia.</p

MOESM9 of Allogeneic stem-cell transplantation for multiple myeloma: a systematic review and meta-analysis from 2007 to 2017

Additional file 9: Figure S5. Funnel plot of progression-free survival (PFS) at 1 year (a), 2 years (b), 3 years (c),and 5 years (d)

MOESM5 of Allogeneic stem-cell transplantation for multiple myeloma: a systematic review and meta-analysis from 2007 to 2017

Additional file 5: Figure S1. Forest plot of the subgroup overall survival (OS) benefit (auto-allo vs only-allo, auto-allo vs tandem auto, MA vs RIC, high-risk vs standard-risk, first-line vs salvage therapy) (a), (post-transplantation in CR vs in non-CR, at transplantation in CR vs in non-CR, over 50 vs under 50, PBSC vs BM, aGVHD vs non-aGVHD, cGVHD vs non-cGVHD) (b)

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Additional file 14: Figure S10. Sensitivity analysis diagram of progression-free survival (PFS) at 1 year (a), 2 years (b), 3 years (c),and 5 years (d)

MOESM10 of Allogeneic stem-cell transplantation for multiple myeloma: a systematic review and meta-analysis from 2007 to 2017

Additional file 10: Figure S6. Funnel plot of treatment-related mortality (TRM) at 100 days (a), 1 year (b), 2 years (c), 3 years (d), and 5 years (e)

MOESM3 of Allogeneic stem-cell transplantation for multiple myeloma: a systematic review and meta-analysis from 2007 to 2017

Additional file 3: Table S3. Quality assessment of individual clinical trials

MOESM17 of Allogeneic stem-cell transplantation for multiple myeloma: a systematic review and meta-analysis from 2007 to 2017

Additional file 17: Figure S13. Sensitivity analysis diagram of relapse rate (a) and death (b)

MOESM15 of Allogeneic stem-cell transplantation for multiple myeloma: a systematic review and meta-analysis from 2007 to 2017

Additional file 15: Figure S11. Sensitivity analysis diagram of treatment-related mortality (TRM) at 100 days (a), 1 year (b), 2 years (c), 3 years (d),and 5 years (e)

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Additional file 12: Figure S8. Funnel plot of relapse rate (a) and death (b)