WuYun: Exploring hierarchical skeleton-guided melody generation using knowledge-enhanced deep learning

Although deep learning has revolutionized music generation, existing methods for structured melody generation follow an end-to-end left-to-right note-by-note generative paradigm and treat each note equally. Here, we present WuYun, a knowledge-enhanced deep learning architecture for improving the structure of generated melodies, which first generates the most structurally important notes to construct a melodic skeleton and subsequently infills it with dynamically decorative notes into a full-fledged melody. Specifically, we use music domain knowledge to extract melodic skeletons and employ sequence learning to reconstruct them, which serve as additional knowledge to provide auxiliary guidance for the melody generation process. We demonstrate that WuYun can generate melodies with better long-term structure and musicality and outperforms other state-of-the-art methods by 0.51 on average on all subjective evaluation metrics. Our study provides a multidisciplinary lens to design melodic hierarchical structures and bridge the gap between data-driven and knowledge-based approaches for numerous music generation tasks

Homozygous p.Ser267Phe in SLC10A1 is associated with a new type of hypercholanemia and implications for personalized medicine.

SLC10A1 codes for the sodium-taurocholate cotransporting polypeptide (NTCP), which is a hepatocellular transporter for bile acids (BAs) and the receptor for hepatitis B and D viruses. NTCP is also a target of multiple drugs. We aimed to evaluate the medical consequences of the loss of function mutation p.Ser267Phe in SLC10A1. We identified eight individuals with homozygous p.Ser267Phe mutation in SLC10A1 and followed up for 8-90 months. We compared their total serum BAs and 6 species of BAs with 170 wild-type and 107 heterozygous healthy individuals. We performed in-depth medical examinations and exome sequencing in the homozygous individuals. All homozygous individuals had persistent hypercholanemia (P = 5.8 × 10-29). Exome sequencing excluded the involvement of other BA metabolism-associated genes in the hypercholanemia. Although asymptomatic, all individuals had low vitamin D levels. Of six adults that were subjected to bone mineral density analysis, three presented with osteoporosis/osteopenia. Sex hormones and blood lipids were deviated in all subjects. Homozygosity of p.Ser267Phe in SLC10A1 is associated with asymptomatic hypercholanemia. Individuals with homozygous p.Ser267Phe in SLC10A1 are prone to vitamin D deficiency, deviated sex hormones and blood lipids. Surveillance of these parameters may also be needed in patients treated with drugs targeting NTCP.This project is supported by the National Natural Science Foundation of China (31471193, 81570539, 81370535, 91331204 and 31525014). S.X. acknowledges financial support from the Strategic Priority Research Program (XDB13040100) and Key Research Program of Frontier Sciences (QYZDJ-SSW-SYS009) of the Chinese Academy of Sciences (CAS)

Superpixel-Based Classification Using K Distribution and Spatial Context for Polarimetric SAR Images

Classification techniques play an important role in the analysis of polarimetric synthetic aperture radar (PolSAR) images. PolSAR image classification is widely used in the fields of information extraction and scene interpretation or is performed as a preprocessing step for further applications. However, inherent speckle noise of PolSAR images hinders its application on further classification. A novel supervised superpixel-based classification method is proposed in this study to suppress the influence of speckle noise on PolSAR images for the purpose of obtaining accurate and consistent classification results. This method combines statistical information with spatial context information based on the stochastic expectation maximization (SEM) algorithm. First, a modified simple linear iterative clustering (SLIC) algorithm is utilized to generate superpixels as classification elements. Second, class posterior probabilities of superpixels are calculated by a K distribution in iterations of SEM. Then, a neighborhood function is defined to express the spatial relationship among adjacent superpixels quantitatively, and the class posterior probabilities are updated by this predefined neighborhood function in a probabilistic label relaxation (PLR) procedure. The final classification result is obtained by the maximum a posteriori decision rule. A simulated image, a spaceborne RADARSAT-2 image, and an airborne AIRSAR image are used to evaluate the proposed method, and the classification accuracy of our proposed method is 99.28%, 93.16% and 89.70%, respectively. The experimental results indicate that the proposed method obtains more accurate and consistent results than other methods

Boosting Evaporative Cooling Performance with Microporous Aerogel

Hydrogel-based evaporative cooling with a low carbon footprint is regarded as a promising technology for thermal regulation. Yet, the efficiency of hydrogel regeneration at night generally mismatches with vapor evaporation during the day, resulting in a limited cooling time span, especially in arid regions. In this work, we propose an efficient approach to improve hydrogel cooling performance, especially the cooling time span, with a bilayer structure, which comprises a bottom hydrogel layer and an upper aerogel layer. The microporous aerogel layer can reduce the saturation vapor density at the hydrogel surface by employing daytime radiative cooling, together with increased convective heat transfer resistance by thermal insulation, thus boosting the duration of evaporative cooling. Specifically, the microstructure of porous aerogel for efficient radiative cooling and vapor transfer is synergistically optimized with a cooling performance model. Results reveal that the proposed structure with a 2-mm-thick SiO2 aerogel can reduce the temperature by 1.4 °C, meanwhile extending the evaporative cooling time span by 11 times compared to a single hydrogel layer

颐和“智”苑

Yizhiyuan can control lighting, fans, air conditioning, ambient lights, TV, curtains and other furniture, and can also adjust the brightness, speed, volume, lighting mode and so on.And equipped with intelligent voice recognition for control, more convenient.Through the PC, the intelligent living system can locate the living location, detect smoke, gas concentration, light intensity, temperature and humidity, control the switch of the master bedroom light, living room light, hall light and curtain by voice, as well as weather monitoring function.Users can view the data detected by the sensor nodes and the status of home appliances through the "YiheZhiyuan" APP installed on the mobile platform, and adjust the status of home appliances at the same time

Feasibility study on SiO2f/SiO2 composites processed by diamond tools

The thin-wall shell parts manufactured by quartz fiber reinforced ceramic matrix composites have low machining efficiency and bigger cutting force, which can easily lead to broken parts and bad surface roughness not meeting the requirements. To solve these problems and seek feasible cutting tool and process parameters, based on the principles of micro cutting, the feasibility study of SiO2f/SiO2 was carried out by using the developed integral multi-edge PCD tool and electroplated diamond grinding tool. The experimental results show that the integral multi-edge PCD tool, designed based on the micro-edge cutting principle, can achieve a large cutting depth and a large cutting efficiency, but its cutting force is relatively huge. Compared with the integral multi-edge PCD tool, electroplated diamond grinding tool have lower cutting force, better surface quality and lower surface roughness

基于物联网技术的智疗手环系统设计

This paper introduces the design of intelligent Therapy Bracelet system based on Internet of things technology. The smart Therapy Bracelet system mainly realizes the functions of blood pressure detection, blood pressure value viewing, historical blood pressure value viewing, peripheral services, personal information, account setting, etc. Firstly, the research background and demand analysis of the intelligent Therapy Bracelet system are analyzed, and then the function modules of the system are designed. Finally, the hardware is selected and designed according to the required functions and performance requirements, and the system functions are realized. Through the test, the system runs well, can achieve the expected goal, and has good application value