学会抄録

Risk of bias. (TIF 107 kb

DataSheet_1_Causal atlas between inflammatory bowel disease and mental disorders: a bi-directional 2-sample Mendelian randomization study.pdf

BackgroundThe brain-gut axis link has attracted increasing attention, with observational studies suggesting that the relationship between common mental disorders and inflammatory bowel disease (IBD) may run in both directions. However, so far, it is not clear whether there is causality and in which direction.MethodsWe conducted a bidirectional 2-sample Mendelian randomization study to investigate the relationship between IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), and mental disorders, using summary-level GWAS data. The main analysis was the inverse variance weighted method. IBD (including CD and UC), and nine mental disorders were used as both exposures and outcomes.ResultsWe found that UC could significantly lead to obsessive-compulsive disorder, attention deficit hyperactivity disorder, and autism spectrum disorder, with odds ratio (OR) of 1.245 (95% confidence intervals [CI]: 1.069-1.450; P=0.008), 1.050 (95%CI: 1.023-1.077; P=2.42×10-4), and 1.041 (95%CI: 1.015-1.068; P=0.002) respectively. In addition, we found that bipolar disorder and schizophrenia could increase the odds of IBD, with OR values of 1.138 (95%CI: 1.084-1.194; P=1.9×10-7), and 1.115 (95%CI: 1.071-1.161; P=1.12×10-7), respectively. Our results also indicate that obsessive-compulsive disorder could lead to IBD, especially for UC, with OR values of 1.091 (95%CI: 1.024-1.162; P=0.009), and 1.124 (95%CI: 1.041-1.214; P=0.004), respectively.ConclusionsOur findings indicate that the brain-gut axis involves the association between IBD, especially UC, and some mental disorders, which guides the targeted prevention, management, and mechanism exploration of these diseases.</p

Presentation_1_Causal atlas between inflammatory bowel disease and mental disorders: a bi-directional 2-sample Mendelian randomization study.pdf

BackgroundThe brain-gut axis link has attracted increasing attention, with observational studies suggesting that the relationship between common mental disorders and inflammatory bowel disease (IBD) may run in both directions. However, so far, it is not clear whether there is causality and in which direction.MethodsWe conducted a bidirectional 2-sample Mendelian randomization study to investigate the relationship between IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), and mental disorders, using summary-level GWAS data. The main analysis was the inverse variance weighted method. IBD (including CD and UC), and nine mental disorders were used as both exposures and outcomes.ResultsWe found that UC could significantly lead to obsessive-compulsive disorder, attention deficit hyperactivity disorder, and autism spectrum disorder, with odds ratio (OR) of 1.245 (95% confidence intervals [CI]: 1.069-1.450; P=0.008), 1.050 (95%CI: 1.023-1.077; P=2.42×10-4), and 1.041 (95%CI: 1.015-1.068; P=0.002) respectively. In addition, we found that bipolar disorder and schizophrenia could increase the odds of IBD, with OR values of 1.138 (95%CI: 1.084-1.194; P=1.9×10-7), and 1.115 (95%CI: 1.071-1.161; P=1.12×10-7), respectively. Our results also indicate that obsessive-compulsive disorder could lead to IBD, especially for UC, with OR values of 1.091 (95%CI: 1.024-1.162; P=0.009), and 1.124 (95%CI: 1.041-1.214; P=0.004), respectively.ConclusionsOur findings indicate that the brain-gut axis involves the association between IBD, especially UC, and some mental disorders, which guides the targeted prevention, management, and mechanism exploration of these diseases.</p

Diagnostic performance of magnifying endoscopy for <i>H</i>. <i>pylori</i> infection.

<p>Diagnostic performance of magnifying endoscopy for <i>H</i>. <i>pylori</i> infection.</p

The diagnostic performance of magnifying endoscopy in predicting <i>H</i>. <i>pylori</i> infection.

<p>(A), pooled sensitivity; (B), pooled specificity; (C), summary receiver operating characteristic curve for diagnosis by magnifying endoscopy. CI, confidence interval; AUC, area under the curve; SE, standard error.</p

Diagnostic Performance of Magnifying Endoscopy for <i>Helicobacter pylori</i> Infection: A Meta-Analysis

<div><p>Background</p><p>Diagnosis of <i>Helicobacter pylori</i> (<i>H</i>. <i>pylori</i>) infection using magnifying endoscopy offers advantages over conventional invasive and noninvasive tests.</p><p>Objective</p><p>This meta-analysis aimed to assess the diagnostic performance of magnifying endoscopy in the prediction of <i>H</i>. <i>pylori</i> infection.</p><p>Methods</p><p>A literature search of the PubMed, Medline, EMBASE, Science Direct and the Cochrane Library databases was performed. A random-effects model was used to calculate the diagnostic efficiency of magnifying endoscopy for <i>H</i>. <i>pylori</i> infection. A summary receiver operator characteristic curve was plotted, and the area under the curve (AUC) was calculated.</p><p>Results</p><p>A total of 18 studies involving 1897 patients were included. The pooled sensitivity and specificity of magnifying endoscopy to predict <i>H</i>. <i>pylori</i> infection were 0.89 [95% confidence interval (CI) 0.87–0.91] and 0.82 (95%CI 0.79–0.85), respectively, with an AUC of 0.9461. When targeting the gastric antrum, the pooled sensitivity and specificity were 0.82 (95%CI 0.78–0.86) and 0.72 (95%CI 0.66–0.78), respectively. When targeting the gastric corpus, the pooled sensitivity and specificity were 0.92 (95%CI 0.90–0.94) and 0.86 (95%CI 0.82–0.88), respectively. The pooled sensitivity and specificity using magnifying white light endoscopy were 0.90 (95%CI 0.87–0.91) and 0.81 (95%CI 0.77–0.84), respectively. The pooled sensitivity and specificity using magnifying chromoendoscopy were 0.87 (95%CI 0.83–0.91) and 0.85 (95%CI 0.80–0.88), respectively. The “pit plus vascular pattern” classification in the gastric corpus observed by magnifying endoscopy was able to accurately predict the status of <i>H</i>. <i>pylori</i> infection, as indicated by a pooled sensitivity and specificity of 0.96 (95%CI 0.94–0.97) and 0.91 (95%CI 0.87–0.93), respectively, with an AUC of 0.9872.</p><p>Conclusions</p><p>Magnifying endoscopy was able to accurately predict the status of <i>H</i>. <i>pylori</i> infection, either in magnifying white light endoscopy or magnifying chromoendoscopy mode. The “pit plus vascular pattern” classification in the gastric corpus is an optimum diagnostic criterion.</p></div

Proportion of studies with low, high, or unclear concerns regarding applicability, %.

<p>Proportion of studies with low, high, or unclear concerns regarding applicability, %.</p

The diagnostic performance of a “pit plus vascular pattern” classification in the gastric corpus by magnifying endoscopy in predicting <i>H</i>. <i>pylori</i> infection.

<p>(A), pooled sensitivity; (B), pooled specificity; (C), summary receiver operating characteristic curve for diagnosis by magnifying endoscopy. CI, confidence interval; AUC, area under the curve; SE, standard error.</p

Deeks’ funnel plot to evaluate publication bias.

<p><i>P</i> = 0.83 indicates a symmetrical funnel shape and suggests that publication bias is absent.</p

Flow diagram of the study selection process for the meta-analysis.

<p>Finally, 18 studies were identified from the 12 articles.</p