Pseudoxanthoma elasticum and obstetric epidural analgesia: Report of a case

peer reviewedPseudoxanthoma elasticum is a rare inherited disorder of the elastic tissue characterised by multisystem manifestations. Skin, eyes, gastro-intestinal system and cardiovascular system are the major affected systems. We describe the anaesthetic management of a parturient affected by this disease

Pseudoxanthoma elasticum and pregnancy.

A 29-year-old woman affected by pseudoxanthoma elasticum gave birth to her second child in our department, thirteen months after the delivery of her first boy. Her care illustrates many of the potential risks of this rare autosomal systemic disorder. In order to detect any changes due to pregnancy, ophthalmologic and cardiologic screening examinations should be performed in the beginning of the pregnancy and repeated several weeks after the delivery. During labor, epidural anesthesia seems to be more advantageous

A Fast Timing Separation of Events Algorithm for Concurrent Systems

In this work, we present a fast, polynomial time implementation of the Timing Separation of Events (TSE) Algorithm, with complexity O(E × (V+E). TSE computation is a fundamental problem in the analysis of event-driven, asynchronous systems, when uncertainty is present, and event delays are specified as [min, max] intervals. The maximum or minimum TSE may be needed, based on the timing analysis required. In this work, we present a novel approach to solving the TSE computation problem, which utilises: (1) the Primal-Dual Method Algorithm of [1] to compute the system period and critical cycle, as well as annotate timing offsets to events, based on the minimum delay values, and (2) an unfolding scheme, on the event graph, to compute the maximum delay between source and target. We show that only a maximum of three unfoldings are necessary, based on the relative delays between source and target events. We present results on a set of classical TSE examples. Our results are correct and identical to [2], but our approach resolves the issue of deciding how many unfoldings are needed to achieve periodic behaviour, and is sianificantly faster than all other methods. © 2019 IEEE

Outcome of laparoscopic sacrocolpopexy with anterior and posterior mesh

Aim: The assessment of the postoperative outcome following laparoscopic sacrocolpopexy using anterior and posterior mesh

CD56 as a useful marker in the regenerative process of the histological progression of primary biliary cirrhosis

Objective Owing to recent contradicting results in the study of the regenerative process after hepatic injury in primary biliary cirrhosis, we investigated the use of CD56 in tissue repair during the histological progression of primary biliary cirrhosis. Methods Fifty-three specimens were classified into Ludwig's stages (1-4) as follows: 14 specimens as stage 1, 23 as stage 2, 14 as stage 3, and two as stage 4. Immunohistochemical stain was performed for CD56. The cell types expressing the marker were morphologically analyzed to determine their origin. Results In normal liver biliary epithelial cells (including the epithelium of terminal bile ducts and bile ductules), hepatocytes, and intermediate cells (features between hepatocytes and biliary cells, distributed in interface between hepatic parenchyma and portal tract) were CD56-. In primary biliary cirrhosis specimens, biliary epithelial cells, hepatocytes, and intermediate cells were CD56+ distributed as 10 out of 14 cases as stage 1 (71.43%), 18 out of 23 as stage 2 (78.26%), nine out of 14 as stage 3 (64.28%), and two out of two as stage 4 (100%). The total positive cases were 39 of 53 (73.58%). CD56 was expressed equally in all three types of cells. Conclusion These findings indicate that the consistent and uniform expression of CD56 in biliary epithelial cells, hepatocytes, and intermediate cells during hepatic injury in primary biliary cirrhosis is probably related to cellular damage and may be important in tissue regeneration. Furthermore, we cannot distinguish a specific cell type from the three above mentioned ones (biliary epithelial cells, hepatocytes, intermediate cells) as a putative stem cell in primary biliary cirrhosis. © 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins