2 research outputs found
Disposable Copper-Based Electrochemical Sensor for Anodic Stripping Voltammetry
In
this work, we report the first copper-based point-of-care sensor
for electrochemical measurements demonstrated by zinc determination
in blood serum. Heavy metals require careful monitoring, yet current
methods are too complex for a point-of-care system. Electrochemistry
offers a simple approach to metal detection on the microscale, but
traditional carbon, gold (Au), or platinum (Pt) electrodes are difficult
or expensive to microfabricate, preventing widespread use. Our sensor
features a new low-cost electrode material, copper, which offers simple
fabrication and compatibility with microfabrication and PCB processing,
while maintaining competitive performance in electrochemical detection.
Anodic stripping voltammetry of zinc using our new copper-based sensors
exhibited a 140 nM (9.0 ppb) limit of detection (calculated) and sensitivity
greater than 1 μA/μM in the acetate buffer. The sensor
was also able to determine zinc in a bovine serum extract, and the
results were verified with independent sensor measurements. These
results demonstrate the advantageous qualities of this lab-on-a-chip
electrochemical sensor for clinical applications, which include a
small sample volume (μL scale), reduced cost, short response
time, and high accuracy at low concentrations of analyte
Copper-Based Electrochemical Sensor with Palladium Electrode for Cathodic Stripping Voltammetry of Manganese
In
this work, we report on the development of a palladium-based,
microfabricated point-of-care electrochemical sensor for the determination
of manganese using square wave cathodic stripping voltammetry. Heavy
metals require careful monitoring, yet current methods are too complex
for a point-of-care system. Voltammetry offers an attractive approach
to metal detection on the microscale, but traditional carbon, gold,
or platinum electrodes are difficult or expensive to microfabricate,
preventing widespread use. Our sensor uses palladium working and auxiliary
electrodes and integrates them with a copper-based reference electrode
for simple fabrication and compatibility with microfabrication and
printed circuit board processing, while maintaining competitive performance
in electrochemical detection. Copper electrodes were prepared on glass
substrate using a combination of microfabrication procedures followed
by electrodeposition of palladium. The disposable sensor system was
formed by bonding a polyÂ(dimethylsiloxane) (PDMS) well to the glass
substrate. Cathodic stripping voltammetry of manganese using our new
disposable palladium-based sensors exhibited 334 nM (18.3 ppb) limit
of detection in borate buffer. The sensor was used to demonstrate
manganese determination in natural water samples from a pond in Burnet
Woods, located in Cincinnati, OH, and the Ohio River