Gemini principles-based digital twin maturity model for asset management

Various maturity models have been developed for understanding the diffusion and implementation of new technologies/approaches. However, we find that existing maturity models fail to understand the implementation of emerging digital twin technique comprehensively and quantitatively. This research aims to develop an innovative maturity model for measuring digital twin maturity for asset management. This model is established based on Gemini Principles to form a systematic view of digital twin development and implementation. Within this maturity model, three main dimensions consisting of nine sub-dimensions have been defined firstly, which were further articulated by 27 rubrics. Then, a questionnaire survey with 40 experts involved is designed and conducted to examine these rubrics. This model is finally illustrated and validated by two case studies in Shanghai and Cambridge. The results show that the digital twin maturity model is effective to qualitatively evaluate and compare the maturity of digital twin implementation at the project level. It can also initiate the roadmap for improving the performance of digital twin supported asset management

Synthesis of 18-Membered Open-Cage Fullerenes through Controlled Stepwise Fullerene Skeleton Bond Cleavage Processes and Substituent-Mediated Tuning of the Redox Potential of Open-Cage Fullerenes

Oxidation of the fullerenediol C₆₀(OH)₂(O)­(OAc)­(OO<i>t</i>Bu)₃ with PhI­(OAc)₂ yields the open-cage fullerene derivative C₆₀(O)₂(O)­(OAc)­(OO<i>t</i>Bu)₃ <b>2</b> with an 11-membered orifice. Compound <b>2</b> reacts with aniline to form a new open-cage derivative with a 14-membered orifice, which yields an 18-membered open-cage fullerene derivative upon addition of another molecule of aniline. Two different types of aniline derivatives with either electron-donating or electron-withdrawing substituents can be added sequentially, affording an unsymmetrical moiety in the open-cage structure. Reduction potentials of the 18-membered open-cage fullerene derivatives can be fine-tuned by changing the substituents on the aniline. The results provide new insights about the mechanism of open-cage reactions of fullerene-mixed peroxide

Additional file 1 of Faecalibacterium prausnitzii as a potential Antiatherosclerotic microbe

Additional file 1. Supplementary materials

Study flow chart.

<p>DNA:desoxy-ribonucleic acid; PTCA, conventional balloon angioplasty.</p

Study of Ion Transfer Coupling with Electron Transfer by Hydrophilic Droplet Electrodes

In a hydrophilic droplet three-electrode system, electroactive species within the droplet play very important roles in the electron-transfer (ET) process on the solid/electrolyte interface, which can then induce an ion-transfer (IT) reaction at the liquid/liquid interface. In this work, several redox couples and electroactive species are chosen to study ET–IT coupling processes at the water/1,2-dichloroethane (W/DCE) interface by cyclic voltammetry (CV) and Osteryoung square wave voltammetry (OSWV). Among them, the redox couple Ru­(NH₃)₆^3+/2+ has been found to have the widest useful potential window of about 1.2 V. A hydrophilic droplet three-electrode system using a single electroactive molecule instead of a redox couple has been confirmed to be stable and has similar functionality to a redox couple. In addition, the lipophilicity of antiplatelet drug clopidogrel at the W/DCE interface is investigated and its ionic partition diagram has been constructed. Protonated clopidogrel is detected in a linear concentration range of 5.0–50 μM and the limit of detection (LOD) is calculated to be 3.0 μM by using the hydrophilic droplet system Ru­(NH₃)₆^3+/2+ and OSWV

Accumulated Major Adverse Events During the One-year Period After Intervention.

<p>Accumulated Major Adverse Events During the One-year Period After Intervention.</p

Association of <i>SAA1</i> and <i>SAA2</i> SNPs with HDL.

§<p>analysis of covariance adjusted for sex and age;</p>‡<p>Unadjusted model;</p><p>*recessive model;</p>†<p>dominant model;</p>⋇<p>additive model.</p

Primer sequences of each SNP.

<p>Note:</p><p>*Because rs2229338, rs12218, and rs1059559 all locates on the exon 4, we used the same primer pairs.</p

Restriction fragment length polymorphism analyses for determination of genotype (A).

<p>The CT genotype shows three bands of 286 bp, 153 bp, and 133 bp (1 and 2); the CC genotype shows two bands of 153 bp and 133 bp (3, 4 and 5). Nucleotide sequences around the 698C>T polymorphism (a, CT genotype; b, CC genotype) (<b>B</b>).</p

Kaplan – Meier Curves for Event free Survival According to CYP2C19 Loss-of-Function Allele Carrier Status among Chinese Patients with CAD following PCI.

<p>Kaplan – Meier Curves for Event free Survival According to CYP2C19 Loss-of-Function Allele Carrier Status among Chinese Patients with CAD following PCI.</p