Triboelectric effect based instantaneous self-powered wireless sensing with self-determined identity

Sensors are the foundation of modern Internet of Things, artificial intelligent, smart manufacturing etc, but most of them require power to operate without spontaneous unique identifiable function. Herein we propose a novel instantaneous force-driven self-powered self-identified wireless sensor based on triboelectric effect to meet the huge demand of true self-powered wireless sensors. The device consists of a microswitch controlled triboelectric nanogenerator (TENG) in parallel with a capacitor-inductor oscillating circuit, and a wireless transmitter. The system is fully powered by the output of the TENG to generate a resonant frequency containing sensing and device identity information, which is then coupled to the transmitter for realizing a long-range wireless communication. The device, with the multiple functions of energy harvesting, sensing, identity generation and wireless signal transmission, is a standalone device, which responds to each trigger without losing sensing information. It eliminates the requirement of electric components for traditional wireless communication, such as rectification circuit, energy storage units, microprocessor, wireless communication chip, etc. Thus, we developed a true self-powered identifiable wireless sensor with great potential for widespread applications

Durvalumab Plus Carboplatin/Paclitaxel Followed by Maintenance Durvalumab With or Without Olaparib as First-Line Treatment for Advanced Endometrial Cancer: The Phase III DUO-E Trial

PURPOSE Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit in mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially in pMMR disease. METHODS This phase III, global, double-blind, placebo-controlled trial randomly assigned eligible patients with newly diagnosed advanced or recurrent endometrial cancer 1:1:1 to: carboplatin/paclitaxel plus durvalumab placebo followed by placebo maintenance (control arm); carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib placebo (durvalumab arm); or carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab plus olaparib (durvalumab + olaparib arm). The primary end points were progression-free survival (PFS) in the durvalumab arm versus control and the durvalumab + olaparib arm versus control. RESULTS Seven hundred eighteen patients were randomly assigned. In the intention-to-treat population, statistically significant PFS benefit was observed in the durvalumab (hazard ratio [HR], 0.71 [95% CI, 0.57 to 0.89]; P = .003) and durvalumab + olaparib arms (HR, 0.55 [95% CI, 0.43 to 0.69]; P < .0001) versus control. Prespecified, exploratory subgroup analyses showed PFS benefit in dMMR (HR [durvalumab v control], 0.42 [95% CI, 0.22 to 0.80]; HR [durvalumab + olaparib v control], 0.41 [95% CI, 0.21 to 0.75]) and pMMR subgroups (HR [durvalumab v control], 0.77 [95% CI, 0.60 to 0.97]; HR [durvalumab + olaparib v control] 0.57; [95% CI, 0.44 to 0.73]); and in PD-L1-positive subgroups (HR [durvalumab v control], 0.63 [95% CI, 0.48 to 0.83]; HR [durvalumab + olaparib v control], 0.42 [95% CI, 0.31 to 0.57]). Interim overall survival results (maturity approximately 28%) were supportive of the primary outcomes (durvalumab v control: HR, 0.77 [95% CI, 0.56 to 1.07]; P = .120; durvalumab + olaparib v control: HR, 0.59 [95% CI, 0.42 to 0.83]; P = .003). The safety profiles of the experimental arms were generally consistent with individual agents. CONCLUSION Carboplatin/paclitaxel plus durvalumab followed by maintenance durvalumab with or without olaparib demonstrated a statistically significant and clinically meaningful PFS benefit in patients with advanced or recurrent endometrial cancer

Emergency management method for coal mines based on task network planning technology

To improve standardization and automation levels of emergency management in coal mines and solve linking problem between emergency plan and emergency decision, a new emergency management method for coal mines based on task network planning technology was presented. Firstly, emergency preparation plan is standardized treated based on reconfigurability of the emergency preparation preparation plan, each emergency measure is taken as a task to form emergency preparation plan by the task network plan technology; then the emergency plan is used as template for emergency execution plan and thus the complete and standardized emergency execution plan can be quickly formed by correcting the emergency preparation plan according to types, specific circumstances, resource conditions of emergency disposal and moderate personal preference of emergencies. The practical application shows that the method can significantly improve structuralization and digitalization level of emergency preparation plan and emergency execution plan, and can realize the seamless connection between the emergency preparation plan and the emergency execution plan

An improved ant algorithm for Multi-mode Resource Constrained Project Scheduling Problem

Many real-world scheduling problems can be modeled as Multi-mode Resource Constrained Project Scheduling Problems (MRCPSP). However, the MRCPSP is a strong NP-hard problem and very difficult to be solved. The purpose of this research is to investigate a more efficient alternative based on ant algorithm to solve MRCPSP. To enhance the generality along with efficiency of the algorithm, the rule pool is designed to manage numerous priority rules for MRCPSP. Each ant is provided with an independent thread and endowed with the learning ability to dynamically select the excellent priority rules. In addition, all the ants in the ant algorithm have the prejudgment ability to avoid infeasible routes based on the branch and bound method. The algorithm is tested on the well-known benchmark instances in PSPLIB. The computational results validate the effectiveness of the proposed algorithm

Scheduling and Common Due Date Assignment on a Single Parallel-Batching Machine with Batch Delivery

We consider a single parallel-batching machine scheduling problem with delivery involving both batching scheduling and common due date assignment. The orders are first processed on the single parallel-batching machine and then delivered in batches to the customers. The batching machine can process several orders at the same time. The processing time of a production batch on the machine is equal to the longest processing time of the orders assigned into this batch. A common due date for all the orders in the same delivery batch and a delivery date for each order need to be determined in order to minimize total weighted flow time. We first prove that this problem is NP hard in the strong sense. Two optimal algorithms by using dynamic programming are derived for the two special cases with a given sequence of orders on the machine and a given batching in the production part, respectively

Treatment of landfill leachate nanofiltration concentrate by a three-dimensional electrochemical technology with waste aluminum scraps as particle electrodes: Efficacy, mechanisms, and enhancement effect of subsequent electrocoagulation

Landfill leachate nanofiltration concentrate is a kind of wastewater containing high concentrations of color and refractory organics. Herein, we proposed a novel three-dimensional electrochemical technology (3DET) with waste aluminum scraps as particle electrodes for its treatment. The planar and particle electrodes were first optimized. Ti/RuO2 and graphite were used as anodes in the two-dimensional electrochemical technology (2DET). In the light of contaminant removal (color, UV254, COD, and TOC), chlorine reduction, and energy consumption, graphite was selected as planar anodes and cathodes. Moreover, 3DET with Al particle electrodes (Al 3DET) outperformed that with conventional granular activated carbon electrodes, 2DET, and Al particles. At 120 min, the removal efficiencies of color, UV254, COD, and TOC using Al 3DET were 98.94 %, 84.72 %, 51.93 %, and 67.46 %, respectively. UV–vis and EEM spectroscopy, and GC–MS analyses indicate that macromolecular organic matter such as humic-like substances could be effectively degraded and simultaneously removed. Reactive species identification tests including free radical quenching and EPR spectra were conducted. The results indicate that in addition to anodic direct oxidation, indirect oxidation by oxidative species (H2O2, •OH, and RCS) and flocculation by Al species also played a vital role in contaminant removal. Continuous-flow experiments show that Fe EC as a post-treatment step of Al 3DET could effectively provide a neutralization effect for the 3DET effluent and enhance the removal efficiency of contaminants. The total operating cost of combined process was 1.307 USD/m3. This study shows that the Al 3DET-Fe EC process is a promising technology for the treatment of nanofiltration concentrate