Effect of Rydberg-atom-based sensor performance on different Rydberg atom population at one atomic-vapor cell

The atomic-vapor cell is a vital component for Rydberg atomic microwave sensors, and impacts on overall capability of Rydberg sensor. However, the conventional analysis approach on effect of vapor-cell length contains two implicit assumptions, that is, the same atomic population density and buffer gas pressure, which make it unable to accurately capture actual response about effect of Rydberg-atom-based sensor performance on different Rydberg atom population. Here, utilizing a stepped cesium atomic-vapor cell with five different dimensions at the same atomic population density and buffer gas pressure, the height and full width at half maximum of Electromagnetically Induced Transparency(EIT) signal, and the sensitivity of the atomic superheterodyne sensor are comprehensively investigated at the same Rabi frequences(saturated laser power) conditions. It is identified that EIT signal height is proportional to the cell length, full width at half maximum and sensitivity grow with the increment of cell length to a certain extent. Based on the coherent integration signal theory and atomic linear expansion coefficient method, theoretical analysis of the EIT height and sensitivity are further investigated. The results could shed new light on the understanding and design of ultrahigh-sensitivity Rydberg atomic microwave sensors and find promising applications in quantum measurement, communication, and imaging

SK-Net: Deep Learning on Point Cloud via End-to-end Discovery of Spatial Keypoints

Since the PointNet was proposed, deep learning on point cloud has been the concentration of intense 3D research. However, existing point-based methods usually are not adequate to extract the local features and the spatial pattern of a point cloud for further shape understanding. This paper presents an end-to-end framework, SK-Net, to jointly optimize the inference of spatial keypoint with the learning of feature representation of a point cloud for a specific point cloud task. One key process of SK-Net is the generation of spatial keypoints (Skeypoints). It is jointly conducted by two proposed regulating losses and a task objective function without knowledge of Skeypoint location annotations and proposals. Specifically, our Skeypoints are not sensitive to the location consistency but are acutely aware of shape. Another key process of SK-Net is the extraction of the local structure of Skeypoints (detail feature) and the local spatial pattern of normalized Skeypoints (pattern feature). This process generates a comprehensive representation, pattern-detail (PD) feature, which comprises the local detail information of a point cloud and reveals its spatial pattern through the part district reconstruction on normalized Skeypoints. Consequently, our network is prompted to effectively understand the correlation between different regions of a point cloud and integrate contextual information of the point cloud. In point cloud tasks, such as classification and segmentation, our proposed method performs better than or comparable with the state-of-the-art approaches. We also present an ablation study to demonstrate the advantages of SK-Net

BPTF Is Essential for T Cell Homeostasis and Function

Bromodomain PHD Finger Transcription Factor (BPTF), a ubiquitously expressed ATP-dependent chromatin-remodeling factor, is critical for epigenetically regulating DNA accessibility and gene expression. While BPTF is important for the development of thymocytes, its function in mature T cells remains largely unknown. By specifically deleting BPTF from late DN3/DN4 stage of developing T cells, we found that BPTF was critical for the homeostasis of T cells via a cell intrinsic manner. In addition, BPTF was essential for the maintenance and function of Treg cells. Treg cell-specific BPTF deletion led to reduced Foxp3 expression, increased lymphocyte infiltration in the non-lymphoid organs and a systemic autoimmune syndrome. These findings therefore reveal a vital role for BPTF in T and Treg cell function and immune homeostasis

Nano-Subsidence Assisted Precise Integration of Patterned Two-Dimensional Materials for High-Performance Photodetector Arrays

The spatially precise integration of arrays of micro-patterned two-dimensional (2D) crystals onto three-dimensionally structured Si/SiO$_2$ substrates represents an attractive strategy towards the low-cost system-on-chip integration of extended functions in silicon microelectronics. However, the reliable integration of the arrays of 2D materials on non-flat surfaces has thus far proved extremely challenging due to their poor adhesion to underlying substrates as ruled by weak van der Waals interactions. Here we report on a novel fabrication method based on nano-subsidence which enables the precise and reliable integration of the micro-patterned 2D materials/silicon photodiode arrays exhibiting high uniformity. Our devices display peak sensitivity as high as 0.35 A/W and external quantum efficiency (EQE) of ca. 90%, outperforming most commercial photodiodes. The nano-subsidence technique opens a viable path to on-chip integrate 2D crystals onto silicon for beyond-silicon microelectronics.Comment: 41 pages, 5 figures, with S

Relationship between motor performance and cortical activity of older neurological disorder patients with dyskinesia using fNIRS: A systematic review

Background: Neurological disorders with dyskinesia would seriously affect older people’s daily activities, which is not only associated with the degeneration or injury of the musculoskeletal or the nervous system but also associated with complex linkage between them. This study aims to review the relationship between motor performance and cortical activity of typical older neurological disorder patients with dyskinesia during walking and balance tasks.Methods: Scopus, PubMed, and Web of Science databases were searched. Articles that described gait or balance performance and cortical activity of older Parkinson’s disease (PD), multiple sclerosis, and stroke patients using functional near-infrared spectroscopy were screened by the reviewers. A total of 23 full-text articles were included for review, following an initial yield of 377 studies.Results: Participants were mostly PD patients, the prefrontal cortex was the favorite region of interest, and walking was the most popular test motor task, interventional studies were four. Seven studies used statistical methods to interpret the relationship between motor performance and cortical activation. The motor performance and cortical activation were simultaneously affected under difficult walking and balance task conditions. The concurrent changes of motor performance and cortical activation in reviewed studies contained the same direction change and different direction change.Conclusion: Most of the reviewed studies reported poor motor performance and increased cortical activation of PD, stroke and multiple sclerosis older patients. The external motor performance such as step speed were analyzed only. The design and results were not comprehensive and profound. More than 5 weeks walking training or physiotherapy can contribute to motor function promotion as well as cortices activation of PD and stroke patients. Thus, further study is needed for more statistical analysis on the relationship between motor performance and activation of the motor-related cortex. More different type and program sports training intervention studies are needed to perform

Patterns of Convergence and Divergence Between Bipolar Disorder Type I and Type II: Evidence From Integrative Genomic Analyses

Aim: Genome-wide association studies (GWAS) analyses have revealed genetic evidence of bipolar disorder (BD), but little is known about the genetic structure of BD subtypes. We aimed to investigate the genetic overlap and distinction of bipolar type I (BD I) & type II (BD II) by conducting integrative post-GWAS analyses. Methods: We utilized single nucleotide polymorphism (SNP)-level approaches to uncover correlated and distinct genetic loci. Transcriptome-wide association analyses (TWAS) were then approached to pinpoint functional genes expressed in specific brain tissues and blood. Next, we performed cross-phenotype analysis, including exploring the potential causal associations between two BD subtypes and lithium responses and comparing the difference in genetic structures among four different psychiatric traits. Results: SNP-level evidence revealed three genomic loci, SLC25A17, ZNF184, and RPL10AP3, shared by BD I and II, and one locus (MAD1L1) and significant gene sets involved in calcium channel activity, neural and synapsed signals that distinguished two subtypes. TWAS data implicated different genes affecting BD I and II through expression in specific brain regions (nucleus accumbens for BD I). Cross-phenotype analyses indicated that BD I and II share continuous genetic structures with schizophrenia and major depressive disorder, which help fill the gaps left by the dichotomy of mental disorders. Conclusion: These combined evidences illustrate genetic convergence and divergence between BD I and II and provide an underlying biological and trans-diagnostic insight into major psychiatric disorders

Repair of fingertip defect with reverse digital artery island flap and repair of donor site with digital dorsal advancement flap

ObjectiveThe reverse digital artery island flap (RDAF) is widely used in repairing fingertip skin defects based on its good appearance and practicability. However, the donor area of the flap needs skin grafting, which can lead to complications. This retrospective study explored the clinical application of digital dorsal advance flap (DDAF) in repairing the donor site of the reverse digital artery island flap.MethodFrom June 2019 to February 2022, 17 patients with a soft tissue defect of the finger had been restored with the reverse digital artery island flap, and at the same time, the donor area was repaired with digital dorsal advance flap (DDAF). The sensitivity, the active range of motion (ROM) and patient satisfaction were assessed after the operation.ResultsAll flaps survived completely without skin grafting with only one linear scar. The sensory and motor functions of all patients recovered well. Assessment based on the Michigan Hand Outcomes Questionnaire (MHQ) showed satisfactory functional recovery for all patients.ConclusionsReconstruction using RDAF combined with DDAF represents an effective alternative for repairing fingertip skin defects