10 research outputs found

    A structural equation model of feasibility evaluation and project success for publicprivate partnerships in Hong Kong

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    A successful publicprivate partnership (PPP) scheme can be described as one that can lead to the delivery of high-quality end products and/or services, which can satisfy the needs of the community, achieve the intended targets/goals of the government, as well as provide a favorable financial return for the private sector involved with the project. This study aims to establish an evaluation framework for the initial feasibility evaluation of a PPP project that would satisfy all the stakeholders. The factors for evaluating the feasibility of PPP projects can be classified into five broad categories: technical; financial and economic; social; political and legal; and others. Through the structural equation modeling approach, data attained from a questionnaire survey conducted in Hong Kong was analyzed and a model was developed to examine the relationships between different evaluation factors and the overall satisfaction of stakeholders. The results indicate that technical and social aspects are critical to the feasibility of PPP projects, and therefore, are the determining factors for success. This paper should assist relevant stakeholders to improve their understanding on the relative importance of the evaluation factors, and help to establish a comprehensive framework for decision makers to evaluate the feasibility of PPP projects. The predictors for PPP project success were also determined to enrich the knowledge base and help formulate management strategies to better implement the PPP project delivery approach. © 2010 IEEE.published_or_final_versio

    Adopting non-privately funded public-private partnerships in maintenance projects: A case study in Hong Kong

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    Purpose - The purpose of this paper is to establish whether this type of approach is suitable for maintenance schemes from the perspective of both the public agent and the service provider. Until recently, non-privately funded public-private partnerships have been adopted for the maintenance of infrastructure facilities. Design/methodology/approach - In this study, stakeholders involved in a trial of a non-privately funded public-private partnerships project were invited to express their opinions on the success and pitfalls of this type of scheme. Semi-structured interviews were carried out with 12 management and front-line staff of the public and private partners to capture their opinions on the project. A questionnaire survey was also conducted to uncover the views and standpoints of other stakeholders on PPP. A total of 33 respondents completed the questionnaire. Findings - The results indicate that the non-privately funded PPP approach is more cost-effective and efficient in the delivery of maintenance services when compared with the traditional term contract. The performance-based payment mechanism adopted could help improve the quality of maintenance services performed by the contractor. The inspection and programming tasks are transferred to the service provider relieving the workload of the public agency. Most stakeholders who participated in this study agreed that the non-privately funded PPP approach can allow higher flexibility, encourage innovation, enhance cost-effectiveness and improve the efficiency of work when compared with the traditional term contract in the delivery of maintenance services. Originality/value - This paper provides a general introduction to the method adopted in the non-privately funded public-private partnerships approach with particular reference to the maintenance of infrastructure schemes. More important, the potentials and pitfalls of using this type of mechanism with maintenance projects are examined, which helps enhance understanding of this rather unexplored topic. © Emerald Group Publishing Limited.link_to_subscribed_fulltex

    Factors influencing the success of PPP at feasibility stage: a tripartite comparison study in Hong Kong

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    Public Private Partnerships (PPP) have been used extensively in both developing and developed countries in delivering various types of projects, ranging from road construction, railway transport systems to health care facilities and schools. Critical success factors of PPP schemes at the implementation stage were identified. It is however more important for decision-makers to identify the factors for feasibility evaluation of adopting the PPP at the outset. This study aims to explore the key successful ingredients to be assessed at the initial stage of PPP projects as perceived public sector, private consortium and general community so as to attain a ' triple win' scenario, via a questionnaire survey and a series of expert interviews conducted in Hong Kong. Survey results indicate that the most critical factor for evaluating the feasibility of PPP projects, especially to the general community, is an acceptable level of tariff. Cost effectiveness and financial attractiveness are the most important evaluation factors as ranked by the public sector and private consortium respectively. In addition, the existence of a long-term demand for the proposed services, availability of strong private consortium, alignment with government's strategic objectives, as well as reliable service delivery are also rated as highly important to the success of PPP schemes. Addressing the tripartite expectations is indispensable to ensure the feasibility and successful delivery of public services and infrastructure projects via PPP schemes. © 2012 Elsevier Ltd.link_to_subscribed_fulltex

    Induction of apoptosis through oxidative stress-related pathways in MCF-7, human breast cancer cells, by ethyl acetate extract of Dillenia suffruticosa

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    Background Breast cancer is one of the most dreading types of cancer among women. Herbal medicine has becoming a potential source of treatment for breast cancer. Herbal plant Dillenia suffruticosa (Griff) Martelli under the family Dilleniaceae has been traditionally used to treat cancerous growth. In this study, the anticancer effect of ethyl acetate extract of D. suffruticosa (EADs) was examined on human breast adenocarcinoma cell line MCF-7 and the molecular pathway involved was elucidated. Methods EADs was obtained from the root of D. suffruticosa by using sequential solvent extraction. Cytotoxicity was determined by using MTT assay, mode of cell death by cell cycle analysis and apoptosis induction by Annexin-FITC/PI assay. Morphology changes in cells were observed under inverted light microscope. Involvement of selected genes in the oxidative stress-mediated signaling pathway was explored using multiplex gene expression analysis. Results The treatment of EADs caused cytotoxicity to MCF-7 cells in a dose- and time-dependent manner at 24, 48 and 72 hours with IC50 of 76 ± 2.3, 58 ± 0.7 and 39 ± 3.6 μg/mL, respectively. The IC50 of tamoxifen-treated MCF-7 cells was 8 ± 0.5 μg/mL. Induction of apoptosis by EADs was dose- and time- dependent. EADs induced non-phase specific cell cycle arrest at different concentration and time point. The multiplex mRNA expression study indicated that EADs-induced apoptosis was accompanied by upregulation of the expression of SOD1, SOD2, NF-κB, p53, p38 MAPK, and catalase, but downregulation of Akt1. Conclusion It is suggested that EADs induced apoptosis in MCF-7 cells by modulating numerous genes which are involved in oxidative stress pathway. Therefore, EADs has the potential to act as an effective intervention against breast cancer cells

    Redox Proteomics

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