Higher-order QED effects in hadronic processes

In this presentation, we describe the computation of higher-order QED effects relevant in hadronic collisions. In particular, we discuss the calculation of mixed QCD-QED one-loop contributions to the Altarelli-Parisi splittings functions, as well as the pure two-loop QED corrections. We explain how to extend the DGLAP equations to deal with new parton distributions, emphasizing the consequences of the novel corrections in the determination (and evolution) of the photon distributions.Comment: 7 pages, 2 figures. Contribution to the Proceedings of the EPS-HEP 2017 Conferenc

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

Integrin receptor activation initiates the formation of integrin adhesion complexes (IACs) at the cell membrane that transduce adhesion-dependent signals to control a multitude of cellular functions. Proteomic analyses of isolated IACs have revealed an unanticipated molecular complexity; however, a global view of the consensus composition and dynamics of IACs is currently lacking. Here, we have integrated several IAC proteomes and generated a 2,412-protein integrin adhesome. Analysis of this dataset reveals the functional diversity of proteins in IACs and establishes a consensus adhesome of 60 proteins. The consensus adhesome likely represents a core cell adhesion machinery, centred around four axes comprising ILK-PINCH-kindlin, FAK-paxillin, talin-vinculin and α-actinin-zyxin-VASP, and includes underappreciated IAC components such as Rsu-1 and caldesmon. Proteomic quantification of IAC assembly and disassembly detailed the compositional dynamics of the core cell adhesion machinery. The definition of this consensus view of integrin adhesome components provides a resource for the research community

Exploration of the relationship between GRAIL and Cbl-b

Abstract: 2 p. Complete paper: 20 p.The E3 ligases GRAIL and Cbl-b are necessary for the induction of CD4+ T cell anergy. Using CD4+ T cells from wildtype (WT) and Cbl-b knockout (Cbl-B -/-) mice, we investigated the relationship between GRAIL and Cbl-b. Induction of anergy led to an 8-fold increase in GRAIL mRNA expression in WT T cells compared to the Cbl-b -/- T cells. In contrast, ectopic expression of GRAIL in WT and Cbl-b -/- CD4+ T cells led to a 305 decrease in proliferation in both groups relative to their respective GFP-transduced control, providing evidence that GRAIL functions independently of Cbl-b for conveyance of an anergic phenotype. In sum, these data suggest a Cbl-b dependent role for optimal upregulation of GRAIL and mRNA under anergizing conditions and a Cbl-b independent functional role for GRAIL in the anergic phenotype

Use of a Mandibular Plate to Maintain Intergonial Width in a Partially Edentulous Patient Undergoing Mandibular Symphysis Reconstruction

Photograph of a scene on the Lake of the Arbuckles

Detector for measuring energy‐ and angle‐resolved neutral‐particle (EARN) distributions for material desorbed from bombarded surfaces

The design and application of a detector is described, which is capable of simultaneously measuring energy and angular distributions of neutral particles desorbed from surfaces. Specific applications to ion bombardment studies are presented. The detector utilizes the state selectivity, sensitivity, and pulsed characteristics of multiphoton resonance ionization as a time‐of‐flight sensitive postionization technique. A microchannel‐plate element allows position‐sensitive detection of the laser‐ionized particles. Sample data are presented for ground‐state Rh atoms desorbed from clean, ion‐bombarded Rh foil and Rh(111) surfaces

Freeze-Etching and Vapor Matrix Deposition for ToF-SIMS Imaging of Single Cells

Freeze-etching, the practice of removing excess surface water from a sample through sublimation into the vacuum of the analysis environment, has been extensively used in conjunction with electron microscopy. Here, we apply this technique to time-of-flight secondary-ion mass spectrometry (ToF-SIMS) imaging of cryogenically preserved single cells. By removing the excess water which condenses onto the sample in vacuo, a uniform surface is produced that is ideal for imaging by static SIMS. We demonstrate that the conditions employed to remove deposited water do not adversely affect cell morphology and do not redistribute molecules in the topmost surface layers. In addition, we found water can be controllably redeposited onto the sample at temperatures below −100 \ub0C in vacuum. The redeposited water increases the ionization of characteristic fragments of biologically interesting molecules 2-fold without loss of spatial resolution. The utilization of freeze-etch methodology will increase the reliability of cryogenic sample preparations for SIMS analysis by providing greater control of the surface environment. Using these procedures, we have obtained high quality spectra with both atomic bombardment as well as C60+ cluster ion bombardment