3,971 research outputs found
Pigeons and people: mortal enemies or lifelong companions? A case study on staff perceptions of the pigeons on the University of South Africa, Muckleneuk campus
Pigeons have been a part of our lives for as long as we can remember. Some people view them with joy, others disdain. Regardless of the perception, control measures are often implemented against the birds in a bid to reduce their presence in urban environments without considering the views of members of the public in the process. Complaints about pigeon activity are, typically, given more attention than praise for these birds. However, people who are pro-pigeons are often not provided with the forum to express their views of the birds. This study explored the perceptions of staff with regard to the pigeons inhabiting the University of South Africa’s Muckleneuk campus. Two hundred and forty-six participants provided their opinions on the pigeons, their related activities and the perceived impact on staff on the campus. Recognising that both people and urban wildlife play a role of cause-and-effect in human–wildlife conflicts can contribute to understanding peoples’ relationships and perceptions of animals which transgress the boundaries between urbanisation and nature. By considering peoples’ perceptions, attitudes and behaviours towards urban wildlife, management strategies can be significantly informed in the process of mitigating conflict. The study has shown that the negative perception of pigeons, which was assumed to be the position of all the people affected by the pigeons at the University of South Arica’s Muckleneuk campus, is in fact incorrect. Participants would rather encourage the nesting and breeding activities of the pigeons on campus, as they felt that the human–pigeon interactions and the viewing of squabs in nests contributed positively to their work environment. Pigeon control strategies should therefore not solely be on the biological aspect of a perceived pigeon problem, but should also include the human association.ABEERU
Applied Behavioural Ecological and Ecosystem Research UnitEnvironmental Science
Connecting the Holographic and Wilsonian Renormalization Groups
Inspired by the AdS/CFT correspondence, we develop an explicit formal duality
between the planar limit of a d-dimensional gauge theory and a classical field
theory in a (d+1)-dimensional anti-de Sitter space. The key ingredient is the
identification of fields in AdS with generalized Hubbard-Stratonovich
transforms of single-trace couplings of the QFT. We show that the Wilsonian
renormalization group flow of these transformed couplings matches the
holographic (Hamilton-Jacobi) flow of bulk fields along the radial direction in
AdS. This result allows one to outline an AdS/CFT dictionary that does not rely
on string theory.Comment: 11 pages, 1 figure; metadata modified in v2; added references and
minor changes in v3; v4 as published in JHE
Chapter 3: Choosing the Important Outcomes for a Systematic Review of a Medical Test
In this chapter of the Evidence-based Practice Centers Methods Guide for Medical Tests, we describe how the decision to use a medical test generates a broad range of outcomes and that each of these outcomes should be considered for inclusion in a systematic review. Awareness of these varied outcomes affects how a decision maker balances the benefits and risks of the test; therefore, a systematic review should present the evidence on these diverse outcomes. The key outcome categories include clinical management outcomes and direct health effects; emotional, social, cognitive, and behavioral responses to testing; legal and ethical outcomes, and costs. We describe the challenges of incorporating these outcomes in a systematic review, suggest a framework for generating potential outcomes for inclusion, and describe the role of stakeholders in choosing the outcomes for study. Finally, we give examples of systematic reviews that either included a range of outcomes or that might have done so. The following are the key messages in this chapter:
Consider both the outcomes that are relevant to the process of testing and those that are relevant to the results of the test.Consider inclusion of outcomes in all five domains: clinical management effects, direct test effects; emotional, social, cognitive and behavioral effects; legal and ethical effects, and costs.Consider to which group the outcomes of testing are most relevant.Given resource limitations, prioritize which outcomes to include. This decision depends on the needs of the stakeholder(s), who should be assisted in prioritizing the outcomes for inclusion
Reduced functional measure of cardiovascular reserve predicts admission to critical care unit following kidney transplantation
Background: There is currently no effective preoperative assessment for patients undergoing kidney transplantation that is
able to identify those at high perioperative risk requiring admission to critical care unit (CCU). We sought to determine if
functional measures of cardiovascular reserve, in particular the anaerobic threshold (VO2AT) could identify these patients.
Methods: Adult patients were assessed within 4 weeks prior to kidney transplantation in a University hospital with a 37-bed
CCU, between April 2010 and June 2012. Cardiopulmonary exercise testing (CPET), echocardiography and arterial
applanation tonometry were performed.
Results: There were 70 participants (age 41.7614.5 years, 60% male, 91.4% living donor kidney recipients, 23.4% were
desensitized). 14 patients (20%) required escalation of care from the ward to CCU following transplantation. Reduced
anaerobic threshold (VO2AT) was the most significant predictor, independently (OR = 0.43; 95% CI 0.27–0.68; p,0.001) and
in the multivariate logistic regression analysis (adjusted OR = 0.26; 95% CI 0.12–0.59; p = 0.001). The area under the receiveroperating-
characteristic curve was 0.93, based on a risk prediction model that incorporated VO2AT, body mass index and
desensitization status. Neither echocardiographic nor measures of aortic compliance were significantly associated with CCU
admission.
Conclusions: To our knowledge, this is the first prospective observational study to demonstrate the usefulness of CPET as a
preoperative risk stratification tool for patients undergoing kidney transplantation. The study suggests that VO2AT has the
potential to predict perioperative morbidity in kidney transplant recipients
Gate-controlled Guiding of Electrons in Graphene
Ballistic semiconductor structures have allowed the realization of
optics-like phenomena in electronics, including magnetic focusing and lensing.
An extension that appears unique to graphene is to use both n and p carrier
types to create electronic analogs of optical devices having both positive and
negative indices of refraction. Here, we use gate-controlled density with both
p and n carrier types to demonstrate the analog of the fiber-optic guiding in
graphene. Two basic effects are investigated: (1) bipolar p-n junction guiding,
based on the principle of angle-selective transmission though the graphene p-n
interface, and (2) unipolar fiber-optic guiding, using total internal
reflection controlled by carrier density. Modulation of guiding efficiency
through gating is demonstrated and compared to numerical simulations, which
indicates that interface roughness limits guiding performance, with
few-nanometer effective roughness extracted. The development of p-n and
fiber-optic guiding in graphene may lead to electrically reconfigurable wiring
in high-mobility devices.Comment: supplementary materal at
http://marcuslab.harvard.edu/papers/OG_SI.pd
Breaking out of biogeographical modules: range expansion and taxon cycles in the hyperdiverse ant genus Pheidole
published_or_final_versio
Motion robust MR fingerprinting scan to image neonates with prenatal opioid exposure
Background: A noninvasive and sensitive imaging tool is needed to assess the
fast-evolving baby brain. However, using MRI to study non-sedated babies faces
roadblocks, including high scan failure rates due to subjects motion and the
lack of quantitative measures for assessing potential developmental delays.
This feasibility study explores whether MR Fingerprinting scans can provide
motion-robust and quantitative brain tissue measurements for non-sedated
infants with prenatal opioid exposure, presenting a viable alternative to
clinical MR scans. Assessment: MRF image quality was compared to pediatric MRI
scans using a fully crossed, multiple reader multiple case study. The
quantitative T1 and T2 values were used to assess brain tissue changes between
babies younger than one month and babies between one and two months.
Statistical Tests: Generalized estimating equations (GEE) model was performed
to test the significant difference of the T1 and T2 values from eight white
matter regions of babies under one month and those are older. MRI and MRF image
quality were assessed using Gwets second order auto-correlation coefficient
(AC2) with its confidence levels. We used the Cochran-Mantel-Haenszel test to
assess the difference in proportions between MRF and MRI for all features and
stratified by the type of features. Results: In infants under one month of age,
the T1 and T2 values are significantly higher (p<0.005) compared to those
between one and two months. A multiple-reader and multiple-case study showed
superior image quality ratings in anatomical features from the MRF images than
the MRI images. Conclusions: This study suggested that the MR Fingerprinting
scans offer a motion-robust and efficient method for non-sedated infants,
delivering superior image quality than clinical MRI scans and additionally
providing quantitative measures to assess brain development
Holographic and Wilsonian Renormalization Groups
We develop parallels between the holographic renormalization group in the
bulk and the Wilsonian renormalization group in the dual field theory. Our
philosophy differs from most previous work on the holographic RG; the most
notable feature is the key role of multi-trace operators. We work out the forms
of various single- and double-trace flows. The key question, `what cutoff on
the field theory corresponds to a radial cutoff in the bulk?' is left
unanswered, but by sharpening the analogy between the two sides we identify
possible directions.Comment: 31 pages, 3 figures. v2: Minor clarifications. Added reference
Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage.
Colibactin is an assumed human gut bacterial genotoxin, whose biosynthesis is linked to the clb genomic island that has a widespread distribution in pathogenic and commensal human enterobacteria. Colibactin-producing gut microbes promote colon tumour formation and enhance the progression of colorectal cancer via cellular senescence and death induced by DNA double-strand breaks (DSBs); however, the chemical basis that contributes to the pathogenesis at the molecular level has not been fully characterized. Here, we report the discovery of colibactin-645, a macrocyclic colibactin metabolite that recapitulates the previously assumed genotoxicity and cytotoxicity. Colibactin-645 shows strong DNA DSB activity in vitro and in human cell cultures via a unique copper-mediated oxidative mechanism. We also delineate a complete biosynthetic model for colibactin-645, which highlights a unique fate of the aminomalonate-building monomer in forming the C-terminal 5-hydroxy-4-oxazolecarboxylic acid moiety through the activities of both the polyketide synthase ClbO and the amidase ClbL. This work thus provides a molecular basis for colibactin's DNA DSB activity and facilitates further mechanistic study of colibactin-related colorectal cancer incidence and prevention
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