British Theatre Scenography: The Reification of Spectacle

Over the last twenty years, the nature of theatre has changed due to the economic system of production which has led to the use of scenography to advertise the theatre product. Theatre has tried to make itself more attractive in the market place, using whatever techniques available. The technological developments of recent years have enabled the repackaging and sale of theatre productions both nationally and internationally. As a result theatre has become more 'designed' in an attempt to make it an attractive commodity. Scenography has become more prominent and this has changed the authorship of the theatre production, the dramatic text; the experts required by the new technologies have had a different involvement with the product, as they have actively contributed to the scenic image presented. Commercial values may have improved the integrity of theatre design and raised its profile within the profession, with theatre critics and with the academic world but it has proved unable to sell a production, which is ultimately lacking in theatricality and true spectacle. On particular occasions the gratuitous use of technology has been criticised, and as such, has been referred to as 'spectacle'. However, spectacle theatre does not simply mean theatre which uses technology, and so it has become imperative for the word spectacle to be more specifically applied, when used as a critical term to describe a form of theatre production. In this thesis, I intend to look at the significant factors that have led to the types of theatre presented in the last twenty years; to discuss these types of theatre in terms of their means of production and delivery to an audience, and to relate the change in scenographic values with a change in economic values; a change which has particularly affected the means of production, and as such is a vital beginning for any discussion of the scenography of the late twentieth century

Genome-Wide Identification of H-NS-Controlled, Temperature-Regulated Genes in \u3ci\u3eEscherichiacoli \u3c/i\u3eK-12

DNA microarrays demonstrate that H-NS controls 69% of the temperature regulated genes in Escherichia coli K-12. H-NS is shown to be a common regulator of multiple iron and other nutrient acquisition systems preferentially expressed at 37°C and of general stress response, biofilm formation, and cold shock genes highly expressed at 23°C

Conformational modulation of sequence recognition in synthetic macromolecules

The different triplet sequences in high molecular weight aromatic copolyimides comprising pyromellitimide units ("I") flanked by either ether-ketone ("K") or ether-sulfone residues ("S") show different binding strengths for pyrene-based tweezer-molecules. Such molecules bind primarily to the diimide unit through complementary π-π-stacking and hydrogen bonding. However, as shown by the magnitudes of 1H NMR complexation shifts and tweezer-polymer binding constants, the triplet "SIS" binds tweezer-molecules more strongly than "KIS" which in turn bind such molecules more strongly than "KIK". Computational models for tweezer-polymer binding, together with single-crystal X-ray analyses of tweezer-complexes with macrocyclic ether-imides, reveal that the variations in binding strength between the different triplet sequences arise from the different conformational preferences of aromatic rings at diarylketone and diarylsulfone linkages. These preferences determine whether or not chain-folding and secondary π−π-stacking occurs between the arms of the tweezermolecule and the 4,4'-biphenylene units which flank the central diimide residue

The Physical Conditions and Dynamics of the Interstellar Medium in the Nucleus of M83: Observations of CO and CI

This paper presents CI, CO J=4-3, and CO J=3-2 maps of the barred spiral galaxy M83 taken at the James Clerk Maxwell Telescope. Observations indicate a double peaked structure which is consistent with gas inflow along the bar collecting at the inner Lindblad resonance. This structure suggests that nuclear starbursts can occur even in galaxies where this inflow/collection occurs, in contrast to previous studies of barred spiral galaxies. However, the observations also suggest that the double peaked emission may be the result of a rotating molecular ring oriented nearly perpendicular to the main disk of the galaxy. The CO J=4-3 data indicate the presence of warm gas in the nucleus that is not apparent in the lower-J CO observations, which suggests that CO J=1-0 emission may not be a reliable tracer of molecular gas in starburst galaxies. The twelve CI/CO J=4-3 line ratios in the inner 24'' x 24'' are uniform at the 2 sigma level, which indicates that the CO J=4-3 emission is originating in the same hot photon-dominated regions as the CI emission. The CO J=4-3/J=3-2 line ratios vary significantly within the nucleus with the higher line ratios occurring away from peaks of emission along an arc of active star forming regions. These high line ratios (>1) likely indicate optically thin gas created by the high temperatures caused by star forming regions in the nucleus of this starburst galaxy.Comment: 15 pages with 10 figures. To appear in the August 10 1998 issue of The Astrophysical Journa

Tissue-specific in vivo genetic toxicity of nine polycyclic aromatic hydrocarbons assessed using the Muta™Mouse transgenic rodent assay

Test batteries to screen chemicals for mutagenic hazard include several endpoints regarded as effective for detecting genotoxic carcinogens. Traditional in vivo methods primarily examine clastogenic endpoints in haematopoietic tissues. Although this approach is effective for identifying systemically distributed clastogens, some mutagens may not induce clastogenic effects; moreover, genotoxic effects may be restricted to the site of contact and/or related tissues. An OECD test guideline for transgenic rodent (TGR) gene mutation assays was released in 2011, and the TGR assays permit assessment of mutagenicity in any tissue. This study assessed the responses of two genotoxicity endpoints following sub-chronic oral exposures of male Muta™Mouse to 9 carcinogenic polycyclic aromatic hydrocarbons (PAHs). Clastogenicity was assessed via induction of micronuclei in peripheral blood, and mutagenicity via induction of lacZ transgene mutations in bone marrow, glandular stomach, small intestine, liver, and lung. Additionally, the presence of bulky PAH-DNA adducts was examined. Five of the 9 PAHs elicited positive results across all endpoints in at least one tissue, and no PAHs were negative or equivocal across all endpoints. All PAHs were positive for lacZ mutations in at least one tissue (sensitivity = 100%), and for 8 PAHs, one or more initial sites of chemical contact (i.e., glandular stomach, liver, small intestine) yielded a greater response than bone marrow. Five PAHs were positive in the micronucleus assay (sensitivity = 56%). Furthermore, all PAHs produced DNA adducts in at least one tissue. The results demonstrate the utility of the TGR assay for mutagenicity assessment, especially for compounds that may not be systemically distributed.</p

Limiting the impact of destructive analytical techniques through sequential microspatial sampling of the enamel from single teeth

A fundamental research concern within contemporary bioarchaeology is the sensitive balance between the preservation of human remains and the use of destructive techniques to collect information. Here we describe one example of how multiple microspatial destructive/semi-destructive techniques may be carried out in sequence using only the enamel of a single tooth. With careful planning of both sample preparation strategies and sequencing of sampling methods, it is possible to produce multiple datasets, and yet to retain material for future analyses. In this case, enamel from the teeth of 27 individuals who lived during the early medieval period (AD 1170-1198) in Bergen, Norway, were subjected to histological, trace element (LA-ICP-MS), diagenetic (FTIR), and isotopic analyses (δ18O and δ13C, via micromill/multiprep/IRMS)

ROSAT PSPC Observations of the Richest (R≥2R \geq 2) ACO Clusters

We have compiled an X-ray catalog of optically selected rich clusters of galaxies observed by the PSPC during the pointed GO phase of the ROSAT mission. This paper contains a systematic X-ray analysis of 150 clusters with an optical richness classification of $R \geq 2$ from the ACO catalog (Abell, Corwin, and Olowin 1989). All clusters were observed within 45' of the optical axis of the telescope during pointed PSPC observations. For each cluster, we calculate: the net 0.5-2.0 keV PSPC count rate (or $4 \sigma$ upper limit) in a 1 Mpc radius aperture, 0.5-2.0 keV flux and luminosity, bolometric luminosity, and X-ray centroid. The cluster sample is then used to examine correlations between the X-ray and optical properties of clusters, derive the X-ray luminosity function of clusters with different optical classifications, and obtain a quantitative estimate of contamination (i.e, the fraction of clusters with an optical richness significantly overestimated due to interloping galaxies) in the ACO catalog

The \u3ci\u3eN\u3c/i\u3e-Acetyltransferase RimJ Responds to Environmental Stimuli to Repress \u3ci\u3epap\u3c/i\u3e Fimbrial Transcription in \u3ci\u3eEscherichia coli\u3c/i\u3e

In uropathogenic Escherichia coli, P pili (Pap) facilitate binding to host epithelial cells and subsequent colonization. Whereas P pili can be produced at 37°C, the expression of these fimbriae is suppressed at 23°C. Previously, insertion mutations in rimJ, a gene encoding the N-terminal acetyltransferase of ribosomal protein S5, were shown to disrupt this thermoregulatory response, allowing papBA transcription at low temperature. In this study, we created an in-frame deletion of rimJ. This deletion relieved the repressive effects not only of low temperature but also of rich (Luria-Bertani [LB]) medium and glucose on papBA transcription, indicating that RimJ modulates papBA transcription in response to multiple environmental stimuli. papI transcription was also shown to be regulated by RimJ. papBA transcription is also controlled by a phase variation mecha- nism. We demonstrated that the regulators necessary to establish a phase ON state—PapI, PapB, Dam, Lrp, and cyclic AMP-CAP–are still required for papBA transcription in a rimJ mutant strain. rimJ mutations increase the rate at which bacteria transition into the phase ON state, indicating that RimJ inhibits the phase OFF3ON transition. A rimJ hns651 mutant is viable on LB medium but not on minimal medium. This synthetic lethality, along with transcriptional analyses, indicates that RimJ and H-NS work through separate pathways to control papBA transcription. Mutations in rimJ do not greatly influence the transcription of the fan, daa, or fim operon, suggesting that RimJ may be a pap-specific regulator. Overexpression of rimJ under conditions repressive for papBA transcription complements the rimJ mutation but has little effect on tran- scription under activating conditions, indicating that the ability of RimJ to regulate transcription is environ- mentally controlled