Комплексные соединения галогенидов цинка как потенциальные противораковые препараты

The purpose of this review is to summarize currently available evidence implicating vitamin K in the pathogenesis of vascular calcification (VC), in particular arterial medial calcification. In doing so, we try to provide a rationale for an interventional clinical study testing whether vitamin K supplementation can retard VC or even affect cardiovascular mortality in chronic kidney disease patients. Additionally, we wish to give an overview of the current literature indicating potential adverse effects of long-term vitamin K antagonists in this population

Технологическое обоснование и прогнозирование применения кислотных обработок призабойной зоны пластов на месторождениях Западной Сибири

Объектом исследования является призабойная зона терригенного и карбонатного пласта, на которых применяется кислотная обработка. Цель работы – технологическое обоснование и анализ применения кислотных обработок призабойной зоны пластов на месторождениях Западной Сибири. В результате исследования было обосновано применение кислотных обработок призабойной зоны пласта, даны рекомендации по избирательному выбору подходящей технологии и оптимального кислотного состава, предоставлена обобщённый процесс принятия решений, для достижения максимальной эффективности.The object of the study is the bottomhole zone of the terrigenous and carbonate formation, which use acid treatment. The purpose of the work is the technological substantiation and analysis of the use of acid treatments in the bottomhole formation zone in the fields of Western Siberia. As a result of the study, the use of acid treatments in the bottomhole formation zone was substantiated, recommendations were given on the selection of the appropriate technology and the optimal acid composition, a generalized decision-making process was provided to achieve maximum efficiency

Совершенствование механизмов взаимодействия с подрядными организациями в вопросах производственной безопасности

Данная работы посвящена разработке механизмов взаимодействия с подрядными организациями в вопросах производственной безопасности. Объектом исследования являются механизмы взаимодействия с подрядными организациями.This work is devoted to the development of mechanisms of interaction with contractors in matters of industrial safety

Совершенствование техники и технологии заканчивания скважин (зарубежный опыт)

Нефтяная и газовая промышленность России на современном этапе их развития сталкиваются с рядом сложных проблем, успешное решение которых возможно на пути радикальных изменений в технике, технологии и методах организации производственных операций. В условиях растущей конкуренции на мировых рынках и прогрессивного истощения ресурсной базы все более актуальными становятся вопросы использования передовых достижений мировой нефтяной и газовой промышленности в системах и методах разработки месторождений и переработки углеводородного сырья.At the present stage of its development,Russian oil and gas industry faces a number of difficult problems, the successful solution of which is possible by a radical changes in engineering, technologies and methods of organizing production operations. In today's growing competition in the World markets and the progressive deterioration of the resource base, the use of advanced achievements of the global oil and gas industry in the systems and methods of field development and hydrocarbon processing is becoming increasingly important

Software and hardware platform for testing of Automatic Generation Control algorithms

Development and implementation of new Automatic Generation Control (AGC) algorithms requires testing them on a model that adequately simulates primary energetic, information and control processes. In this article an implementation of a test platform based on HRTSim (Hybrid Real Time Simulator) and SCADA CK-2007 (which is widely used by the System Operator of Russia) is proposed. Testing of AGC algorithms on the test platform based on the same SCADA system that is used in operation allows to exclude errors associated with the transfer of AGC algorithms and settings from the test platform to a real power system. A power system including relay protection, automatic control systems and emergency control automatics can be accurately simulated on HRTSim. Besides the information commonly used by conventional AGC systems HRTSim is able to provide a resemblance of Phasor Measurement Unit (PMU) measurements (information about rotor angles, magnitudes and phase angles of currents and voltages etc.). The additional information significantly expands the number of possible AGC algorithms so the test platform is useful in modern AGC system developing. The obtained test results confirm that the proposed system is applicable for the tasks mentioned above

Исследование влияния жесткости конструкции на точность и качество деталей, полученных на установке гидроабразивной резки

Цель магистерской диссертации является исследование влияния жесткости конструкции на точность и качество деталей, полученных на установке гидроабразивной резки. В процессе исследования проводился ряд экспериментальных исследований по определению точности обработки в разных зонах резания при разных режимах, определена статистическая жёсткость системы гидроабразивной обработки. В результате исследования установлен характер погрешностей обработанных поверхностей деталей, получаемых при использовании технологии гидроабразивной резки, выявлены причины появления погрешностей обработки поверхностей деталей, оптимизированы параметры, влияющие на качество и точность обработки, получена математическая модель установки гидроабразивной обработки.The purpose of the master's thesis is to study the influence of structural rigidity on the accuracy and quality of parts obtained at the waterjet cutting plant. During the research, a number of experimental studies were conducted to determine the accuracy of processing in different cutting zones under different modes, and the statistical rigidity of the waterjet processing system was determined. The study of the nature of errors of machined part surfaces obtained by using water jet cutting technology, identified the causes of errors of processing of surfaces of details, the optimized parameters affecting the quality and accuracy of processing, a mathematical model of a hydroabrasive treatment

One-year outcomes after transcatheter insertion of an interatrial shunt device for the management of heart failure with preserved ejection fraction

Background—Heart failure with preserved ejection fraction has a complex pathophysiology and remains a therapeutic challenge. Elevated left atrial pressure, particularly during exercise, is a key contributor to morbidity and mortality. Preliminary analyses have demonstrated that a novel interatrial septal shunt device that allows shunting to reduce the left atrial pressure provides clinical and hemodynamic benefit at 6 months. Given the chronicity of heart failure with preserved ejection fraction, evidence of longer-term benefit is required. Methods and Results—Patients (n=64) with left ventricular ejection fraction ≥40%, New York Heart Association class II–IV, elevated pulmonary capillary wedge pressure (≥15 mm Hg at rest or ≥25 mm Hg during supine bicycle exercise) participated in the open-label study of the interatrial septal shunt device. One year after interatrial septal shunt device implantation, there were sustained improvements in New York Heart Association class (P<0.001), quality of life (Minnesota Living with Heart Failure score, P<0.001), and 6-minute walk distance (P<0.01). Echocardiography showed a small, stable reduction in left ventricular end-diastolic volume index (P<0.001), with a concomitant small stable increase in the right ventricular end-diastolic volume index (P<0.001). Invasive hemodynamic studies performed in a subset of patients demonstrated a sustained reduction in the workload corrected exercise pulmonary capillary wedge pressure (P<0.01). Survival at 1 year was 95%, and there was no evidence of device-related complications. Conclusions—These results provide evidence of safety and sustained clinical benefit in heart failure with preserved ejection fraction patients 1 year after interatrial septal shunt device implantation. Randomized, blinded studies are underway to confirm these observations