Parkinson's Disease and the Environment

Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder that affects an estimated 10 million sufferers worldwide. The two forms of PD include familial and sporadic, and while the etiology of PD is still largely unknown, the condition is likely to be multifactorial with genetic and environmental factors contributing to disease genesis. Diagnosis of the condition is attained through the observation of cardinal clinical manifestations including resting tremor, muscle rigidity, slowness or loss of movement, and postural instability. Unfortunately, by the time these features become apparent extensive neurological damage has already occurred. A cure for PD has not been identified and the current therapy options are pharmaceutical- and/or surgical-based interventions to treat condition symptoms. There is no specific test for PD and most diagnoses are confirmed by a combination of clinical symptoms and positive responses to dopaminergic drug therapies. The prevalence and incidence of PD vary worldwide influenced by several factors such as age, gender, ethnicity, genetic susceptibilities, and environmental exposures. Here, we will present environmental factors implicated in sporadic PD onset. By understanding the mechanisms in which environmental factors interact with, and affect the brain we can stride toward finding the underlying cause(s) of PD

Factors affecting powerlifting performance: an analysis of age- and weight-based determinants of relative strength

Powerlifting (PL) is characterised by the ability to generate maximal force. However, an understanding of the factors affecting strength in PL athletes is poorly understood. Therefore, competition data were analysed from 1368 individuals during 2017. Relative strength was compared for the squat (SQ), bench press (BP) and deadlift (DL) between age groups (Sub-junior [SJ], Junior [JU], Open [OP], and Masters’ I-IV [M1-M4]), weight classes (females; 47 kg, 52 kg, 57 kg, 63 kg, 72 kg, 84 kg and + 84 kg and males; 59 kg, 66 kg, 74 kg, 83 kg, 93 kg, 105 kg, 120 kg, + 120 kg) and between sexes. The results showed that relative strength was greater for males across all lifts (P \u3c 0.001). Relative strength tended to decrease with increasing body mass for males (SQ, BP and DL: P \u3c 0.001, R2 = 0.9306–0.9763) and females (SQ, BP and DL: P \u3c 0.001, R2 = 0.9485–0.9802), and with increasing age for males (SQ, BP and DL: P \u3c 0.001, R2 = 0.4742–0.6729), and females (SQ: P \u3c 0.001, BP: P = 0.002 and DL: P = 0.001, R2 = 0.0844–0.3705), respectively. The findings offer important information regarding factors that affect strength performance in athletes. Coaches should consider the factors influencing strength when developing resistance training programmes or in longer term athletic development for powerlifters and other strength based sports

Long-term strength adaptation: A 15-year analysis of powerlifting athletes

Strength is a fundamental component of athletic performance and development. This investigation examined the long-term strength development of powerlifting (PL) athletes. The rate of strength gain/day was assessed in 1897 PL athletes (F = 626, M = 1,271) over a 15-year period (2003–2018). Independent T-tests explored sex differences in baseline absolute (kg) and relative strength (kg·body mass−1 [bm]) recorded from the first competition, and strength gain/day (kg·d−1). Analyses based on initial strength quartiles were conducted using one-way analysis of variances with significance set at p \u3c 0.05. Bivariate correlational analysis tested for relationships between strength gain/day and baseline strength, the number of competitions, and mean days between competitions. Males had greater absolute (M: 513.3 ± 99.8 kg, F: 289.4 ± 55.7 kg, p \u3c 0.001) and relative (M: 5.89 ± 1.04 kg·bm−1, F: 4.27 ± 0.85 kg·bm−1, p \u3c 0.001) strength at baseline. Overall, strength gain/day (F: 0.12 ± 0.69 kg·d−1, M: 0.15 ± 0.44 kg·d−1, p = 0.318) was similar between sexes. However, the strongest males showed a lower rate of strength improvement (0.102 kg·d−1) compared with least strong males (0.211 kg·d−1), p = 0.010. No differences were observed across quartiles for females. Correlational analyses revealed significant but weak negative relationships between strength gain/day and the mean days between competitions for females (r2 = −0.120, p = 0.003) and males (r2 = −0.190, p \u3c 0.001). Similar relationships were observed for baseline strength (r2 = −0.073, p = 0.009) and the number of competitions (r2 = −0.111, p \u3c 0.001) for males. The results suggest similar strength adaptation between sexes. The strongest males improve more slowly, possibly due to a ceiling effect. Collectively, the findings provide novel evidence of real-world long-term strength adaptations that may be particularly useful to understand athlete development, to aid periodized programming, and to benchmark strength over time

The time-course of acute changes in corticospinal excitability, intra-cortical inhibition and facilitation following a single-session heavy strength training of the biceps brachii

Objective: The current understanding of acute neurophysiological responses to resistance training remains unclear. Therefore, we aimed to compare the time-course of acute corticospinal responses following a single-session heavy strength training (HST) of the biceps brachii (BB) muscle and provide quantifiable evidence based on the super-compensation model in an applied setting. Methods: Fourteen participants completed a counter-balanced, cross-over study that consisted of a single HST session (5 sets × 3 repetition maximum [RM]) of the BB and a control session (CON). Single- and paired-pulse transcranial magnetic stimulation (TMS) was used to measure changes in motor-evoked potential (MEP) amplitude, intra-cortical facilitation (ICF), short-interval intra-cortical inhibition (SICI) and long-interval intra-cortical inhibition (LICI). Additionally, maximal muscle compound wave (MMAX) and maximal voluntary isometric contraction (MVIC) of the BB were taken. All measures were taken at baseline, immediately post and at 10, 20, 30 min and 1, 2, 6, 24, 48 and 72 h post-training. Results: A significant reduction in MEP amplitude was observed immediately post training (P = 0.001), while MVIC (P < 0.001) and MMAX (P = 0.047) were reduced for up to 30 min post-training. An increase in MVIC (p < 0.001) and MMAX (p = 0.047) was observed at 6 h, while an increase in MEP amplitude (p = 0.014) was only observed at 48 and 72 h. No changes in SICI, ICF and LICI were observed. Conclusion: Our results suggest that: (1) acute changes in corticospinal measures returned to baseline in a shorter timeframe than the current super-compensation model (24-48 h) and (2) changes in corticospinal excitability post-HST may be modulated "downstream" of the primary motor cortex (M1)

Exergaming as a viable therapeutic tool to improve static and dynamic balance among older adults and people with idiopathic Parkinson\u27s disease: a systematic review and meta-analysis

The use of virtual reality games (known as "exergaming") as a neurorehabilitation tool is gaining interest. Therefore, we aim to collate evidence for the effects of exergaming on the balance and postural control of older adults and people with idiopathic Parkinson\u27s disease (IPD). Six electronic databases were searched, from inception to April 2015, to identify relevant studies. Standardized mean differences (SMDs) and 95% confidence intervals (CI) were used to calculate effect sizes between experimental and control groups. I (2) statistics were used to determine levels of heterogeneity. 325 older adults and 56 people with IPD who were assessed across 11 -studies. The results showed that exergaming improved static balance (SMD 1.069, 95% CI 0.563-1.576), postural control (SMD 0.826, 95% CI 0.481-1.170), and dynamic balance (SMD -0.808, 95% CI -1.192 to -0.424) in healthy older adults. Two IPD studies showed an improvement in static balance (SMD 0.124, 95% CI -0.581 to 0.828) and postural control (SMD 2.576, 95% CI 1.534-3.599). Our findings suggest that exergaming might be an appropriate therapeutic tool for improving balance and postural control in older adults, but more -large-scale trials are needed to determine if the same is true for people with IPD

The acute neuromuscular responses to cluster set resistance training: A systematic review and meta-analysis

Background: Cluster sets (CSs) are a popular resistance training (RT) strategy categorised by short rest periods implemented between single or groups of repetitions. However, evidence supporting the effectiveness of CSs on acute intra-session neuromuscular performance is still equivocal. Objective: The objective of this investigation was to determine the efficacy of a single session of CSs to attenuate losses in force, velocity and power compared to traditional set (TS) training. Methods: Screening consisted of a systematic search of EMBASE, Google Scholar, PubMed, Scopus and SPORTDiscus. Inclusion criteria were (1) measured one or more of mean/peak force, velocity or power; (2) implemented CSs in comparison to TSs; (3) an acute design, or part thereof; and (4) published in an English-language, peer-reviewed journal. Raw data (mean ± standard deviation) were extracted from included studies and converted into standardised mean differences (SMDs) and ± 95% confidence intervals (CIs). Results: Twenty-five studies were used to calculate SMD ± 95% CI. Peak (SMD = 0.815, 95% CI 0.105–1.524, p = 0.024) and mean (SMD = 0.863, 95% CI 0.319–1.406, p = 0.002) velocity, peak (SMD = 0.356, 95% CI 0.057–0.655, p = 0.019) and mean (SMD = 0.692, 95% CI 0.395–0.990, p \u3c 0.001) power, and peak force (SMD = 0.306, 95% CI − 0.028 to 0.584, p = 0.031) favoured CS. Subgroup analyses demonstrated an overall effect for CS across loads (SMD = 0.702, 95% CI 0.548–0.856, p \u3c 0.001), included exercises (SMD = 0.664, 95% CI 0.413–0.916, p \u3c 0.001), experience levels (SMD = 0.790, 95% CI 0.500–1.080, p \u3c 0.001) and CS structures (SMD = 0.731, 95% CI 0.567–0.894, p \u3c 0.001) with no difference within subgroups. Conclusion: CSs are a useful strategy to attenuate the loss in velocity, power and peak force during RT and should be used to maintain neuromuscular performance, especially when kinetic outcomes are emphasised. However, it remains unclear if the benefits translate to improved performance across all RT exercises, between sexes and across the lifespan

The acute neuromuscular responses to cluster set resistance training: A systematic review and meta-analysis

Background: Cluster sets (CSs) are a popular resistance training (RT) strategy categorised by short rest periods implemented between single or groups of repetitions. However, evidence supporting the effectiveness of CSs on acute intra-session neuromuscular performance is still equivocal. Objective: The objective of this investigation was to determine the efficacy of a single session of CSs to attenuate losses in force, velocity and power compared to traditional set (TS) training. Methods: Screening consisted of a systematic search of EMBASE, Google Scholar, PubMed, Scopus and SPORTDiscus. Inclusion criteria were (1) measured one or more of mean/peak force, velocity or power; (2) implemented CSs in comparison to TSs; (3) an acute design, or part thereof; and (4) published in an English-language, peer-reviewed journal. Raw data (mean ± standard deviation) were extracted from included studies and converted into standardised mean differences (SMDs) and ± 95% confidence intervals (CIs). Results: Twenty-five studies were used to calculate SMD ± 95% CI. Peak (SMD = 0.815, 95% CI 0.105–1.524, p = 0.024) and mean (SMD = 0.863, 95% CI 0.319–1.406, p = 0.002) velocity, peak (SMD = 0.356, 95% CI 0.057–0.655, p = 0.019) and mean (SMD = 0.692, 95% CI 0.395–0.990, p \u3c 0.001) power, and peak force (SMD = 0.306, 95% CI − 0.028 to 0.584, p = 0.031) favoured CS. Subgroup analyses demonstrated an overall effect for CS across loads (SMD = 0.702, 95% CI 0.548–0.856, p \u3c 0.001), included exercises (SMD = 0.664, 95% CI 0.413–0.916, p \u3c 0.001), experience levels (SMD = 0.790, 95% CI 0.500–1.080, p \u3c 0.001) and CS structures (SMD = 0.731, 95% CI 0.567–0.894, p \u3c 0.001) with no difference within subgroups. Conclusion: CSs are a useful strategy to attenuate the loss in velocity, power and peak force during RT and should be used to maintain neuromuscular performance, especially when kinetic outcomes are emphasised. However, it remains unclear if the benefits translate to improved performance across all RT exercises, between sexes and across the lifespan

Cross-activation of the motor cortex during unilateral contractions of the quadriceps

Transcranial magnetic stimulation (TMS) studies have demonstrated that unilateral muscle contractions in the upper limb produce motor cortical activity in both the contralateral and ipsilateral motor cortices. The increase in excitability of the corticomotor pathway activating the resting limb has been termed "cross-activation", and is of importance due to its involvement in cross-education and rehabilitation. To date, very few studies have investigated cross-activation in the lower limb. Sixteen healthy participants (mean age 29 ± 9 years) took part in this study. To determine the effect of varying contraction intensities in the lower limb, we investigated corticomotor excitability and intracortical inhibition of the right rectus femoris (RF) while the left leg performed isometric extension at 0%, 25%, 50%, 75% and 100% of maximum force output. Contraction intensities of 50% maximal force output and greater produced significant cross-activation of the corticomotor pathway. A reduction in silent period duration was observed during 75% and 100% contractions, while the release of short-interval intracortical inhibition (SICI) was only observed during maximal (100%) contractions. We conclude that increasing isometric contraction intensities produce a monotonic increase in cross-activation, which was greatest during 100% force output. Unilateral training programs designed to induce cross-education of strength in the lower limb should therefore be prescribed at the maximal intensity tolerable

Corticospinal and intracortical responses from both motor cortices following unilateral concentric versus eccentric contractions

Cross-education is the phenomenon where training of one limb can cause neuromuscular adaptations in the opposite untrained limb. This effect has been reported to be greater after eccentric (ECC) than concentric (CON) strength training; however, the underpinning neurophysiological mechanisms remain unclear. Thus, we compared responses to transcranial magnetic stimulation (TMS) in both motor cortices following single sessions of unilateral ECC and CON exercise of the elbow flexors. Fourteen healthy adults performed three sets of 10 ECC and CON right elbow flexor contractions at 75 % of respective maximum on separate days. Elbow flexor maximal voluntary isometric contraction (MVIC) torques were measured before and after exercise, and responses to single- and paired-pulse TMS were recorded from the non-exercised left and exercised right biceps brachii. Pre-exercise and post-exercise responses for ECC and CON were compared by repeated measures analyses of variance (ANOVAs). MVIC torque of the exercised arm decreased (p \u3c 0.01) after CON ( − 30 ± 14 %) and ECC ( − 39 ± 13 %) similarly. For the non-exercised left biceps brachii, resting motor threshold (RMT) decreased after CON only ( − 4.2 ± 3.9 % of maximum stimulator output [MSO], p \u3c 0.01), and intracortical facilitation (ICF) decreased (−15.2 ± 20.0 %, p = 0.038) after ECC only. For the exercised right biceps, RMT increased after ECC (8.6 ± 6.2 % MSO, p = 0.014) but not after CON (6.4 ± 8.1% MSO, p = 0.066). Thus, unilateral ECC and CON elbow flexor exercise modulated excitability differently for the non-exercised hemisphere. These findings suggest that responses after a single bout of exercise may not reflect longer term adaptations