Pharmacokinetics and pharmacodynamics of topotecan administered daily for 5 days every 3 weeks

Topotecan is a novel semisynthetic derivative of the anticancer agent camptothecin and inhibits the intranuclear enzyme topoisomerase I. The lactone structure of topotecan, which is in equilibrium with the inactive ringopened hydroxy acid, is essential for this activity. The open form predominates at physiological pH. We performed a pharmacokinetic, study as part of a phase I study in patients with various types of soli

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Item does not contain fulltextBackground paper for the European Congres Knowledge and Work. Knowledge production and dissemination to business and the labour market. Amsterdam, april 1997.[S.l. : s.n.

Stimulering van scholing in de Sociale Werkvoorziening.

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