Description of infants with a first episode of RSV associated pneumonia, by age group.

<p>Description of infants with a first episode of RSV associated pneumonia, by age group.</p

RSV associated pneumonia cases by season and severity.

<p>The mean age of the cohort (dashed line) and the mean monthly rainfall (grey shaded area) are highlighted.</p

The sensitivity, specificity, positive predictive value and negative predictive value of clinical features significantly associated with RSV associated pneumonia.

<p>The sensitivity, specificity, positive predictive value and negative predictive value of clinical features significantly associated with RSV associated pneumonia.</p

NMDS plot based on Jaccard distance (a-c) and Bray-Curtis dissimilarity (d-f), coloured according to age.

<p>a) and d) show 50% ellipses and centroids of the first 12 months of life as an overlay on the full 24-month dataset, while b) and e) show ellipses for 13–24 months overlaid on the full 24-month dataset. Ellipses and datapoints are presented in corresponding colours. Significant OTUs driving the ordination (p<0.0001 and with vector length >0.25) are shown in d) and f). Increasing age is significantly correlated with both x and y axis.</p

Heatmap of pneumococcal serotypes detected in culture per infant.

<p>The mean number of types acquired per child over the study period is 7.4.</p

Virus detection by month of year and total number of NPAs taken.

<p>Virus detection by month of year and total number of NPAs taken.</p

Analysis of clinical signs for associations with RSV infection.

<p>Analysis of clinical signs for associations with RSV infection.</p

Summary of the cohort characteristics.

<p>Summary of the cohort characteristics.</p

Microbiota profile of one child from 1–24 months of age.

<p>Swabs taken during a pneumonia episode are highlighted by boxes. Where cultured, pneumococcal serotype in the sample is indicated in the top pane. OTUs are colour grouped by phylum: Actinobacteria (orange), Bacteroidetes (yellow), Firmicutes (green), Proteobacteria (blue).</p

Significant results from a multivariate Poisson regression model assessing potential risk factors for pneumonia.

<p>In addition to the factors in the table, the multivariate model included all factors from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0054026#pone-0054026-t001" target="_blank">Table 1</a> which were significant in univariate analysis. The following were non-significant:</p>a<p>distance from the household stove to the infants sleeping area.</p>b<p>season of birth.</p>c<p>birth weight and the number of people sleeping in the same bed as the infant.</p