A Method against Interrupted-Sampling Repeater Jamming Based on Energy Function Detection and Band-Pass Filtering

Interrupted-sampling repeater jamming (ISRJ) is a new kind of coherent jamming to the large time-bandwidth linear frequency modulation (LFM) signal. Many jamming modes, such as lifelike multiple false targets and dense false targets, can be made through setting up different parameters. According to the “storage-repeater-storage-repeater” characteristics of the ISRJ and the differences in the time-frequency-energy domain between the ISRJ signal and the target echo signal, one new method based on the energy function detection and band-pass filtering is proposed to suppress the ISRJ. The methods mainly consist of two parts: extracting the signal segments without ISRJ and constructing band-pass filtering function with low sidelobe. The simulation results show that the method is effective in the ISRJ with different parameters

Characterisation of the vitreous proteome in proliferative diabetic retinopathy

Background: Diabetes can lead to serious microvascular complications such as proliferative diabetic retinopathy (PDR), which results in severe vision loss. The diabetes-induced alterations in the vitreous protein composition in diabetic patients with PDR may be responsible for the presence of PDR. The vitreous humour can be utilised in a variety of studies aimed toward the discovery of new targets for the treatment or prevention of PDR and the identification of novel disease mechanisms. The aim of this study was to compare the protein profile of vitreous humour from diabetic patients with PDR with that of vitreous humour from normal human eyes donated for corneal transplant. Results: Vitreous humour from type 2 diabetic patients with PDR (n = 10) and from normal human eyes donated for corneal transplant (n = 10) were studied. The comparative proteomic analysis was performed using twodimensional fluorescence difference gel electrophoresis (2-D DIGE). Differentially produced proteins (abundance ratio> 2 or <-2, p < 0.01) were identified by matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS) and MALDI-TOF tandem mass spectrometry. A total of 1242 protein spots were detected on the 2-D master gel of the samples, and 57 spots that exhibited statistically significant variations were successfully identified. The spots corresponded to peptide fragments of 29 proteins, including 8 proteins tha

The p53 Pathway Controls SOX2-Mediated Reprogramming in the Adult Mouse Spinal Cord

Although the adult mammalian spinal cord lacks intrinsic neurogenic capacity, glial cells can be reprogrammed in vivo to generate neurons after spinal cord injury (SCI). How this reprogramming process is molecularly regulated, however, is not clear. Through a series of in vivo screens, we show here that the p53-dependent pathway constitutes a critical checkpoint for SOX2-mediated reprogramming of resident glial cells in the adult mouse spinal cord. While it has no effect on the reprogramming efficiency, the p53 pathway promotes cell-cycle exit of SOX2-induced adult neuroblasts (iANBs). As such, silencing of either p53 or p21 markedly boosts the overall production of iANBs. A neurotrophic milieu supported by BDNF and NOG can robustly enhance maturation of these iANBs into diverse but predominantly glutamatergic neurons. Together, these findings have uncovered critical molecular and cellular checkpoints that may be manipulated to boost neuron regeneration after SCI

Two Opposite Sides Synchronous Tracking X-ray Based Robotic Welding Inspection System

For inspecting welding seams of large-scale equipment such as storage tanks and spherical tanks, it usually cost much manpower and material, while automated testing robot can achieve fast and accurate detection. Because X-ray Flat Panel Detector is dependent on specialized automated equipment, it can greatly enhance X-ray inspection technology in large storage tanks that applying the Mecanum Omnidirectional Mobile Robot into automated weld detection. In this paper, an X-ray Flat Panel Detector based wall-climbing robotic system is developed for intelligent detecting of welding seams. The robot system consists of two Mecanum vehicles equipped with either a Flat Panel Detector or an X-ray generator and climbing on both side of the tank wall. Inspection robot can carry detector stably with reliable suction force and adapt to different surfaces. To let the X-ray Flat Panel Detector work properly, dual cameras positioning system is used to ensure synchronous operation of the two robots. Some experiment was conducted and reported