The brave new world of endometrial cancer Future implications for adjuvant treatment decisions

Purpose For many decades, endometrial cancer (EC) has been considered as a homogenous tumor entity with good prognosis. The currently valid risk stratification considers clinical and pathological factors. Treatment recommendations differ considerably from country to country. Materials and methods The Cancer Genome Atlas (TCGA) Research Network has shown that ECs should be reclassified into four novel molecular prognostic groups, with the potential of changing adjuvant management of EC patients: ultra-mutated, hyper-mutated, copy-number low, and copy-number high. Clinical examples are shown, and the available literature has been highlighted. The European Society of Gynaecological Oncology (ESGO) guideline for endometrial cancer takes the new classification system into consideration for adjuvant treatment decisions and will be published this year. Results In the near future, we expect new treatment recommendations that may differ considerably from the clinicopathologically driven recommendations on the basis of our deeper insight and better understanding of molecular markers in endometrial cancer. The PORTEC 4a study is the only recruiting study which randomizes patients to adjuvant or no adjuvant treatment on the basis of the aforementioned new classification system. Conclusion The aim of the new classification is a more personalized adjuvant radio(chemo)therapy decision and better oncologic outcomes or avoidance of overtreatment

Entwicklung eines Laserinterferometersystems zum direkten Erfassen von raeumlichen Bewegungen im Maschinenbau Abschlussbericht

TIB Hannover: FR 1251 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Stabilization of Pt Nanoparticles Due to Electrochemical Transistor Switching of Oxide Support Conductivity

Polymer electrolyte fuel cells (PEFCs) offer an efficient way of chemical-to-electrical energy conversion that could drastically reduce the environmental footprint of the mobility and stationary energy supply sectors, respectively. However, PEFCs can suffer from severe degradation during start/stop events, when the cathode catalyst is transiently exposed to very high potentials. In an attempt to mitigate corrosion of conventional carbon support materials for Pt catalyst nanoparticles under these conditions, conductive metal oxides like antimony-doped tin oxide (ATO) are considered alternative support materials with improved corrosion resistance. A combined in situ anomalous small-angle X-ray scattering and post mortem transmission electron microscopy study reveals PEFC-relevant degradation properties of ATO-supported Pt in comparison to carbon-supported Pt catalysts. Against expectation, the superior stability of ATO-supported Pt nanoparticles cannot be merely explained by improved support corrosion resistance. Instead, the dominant loss mechanism of electrochemical Ostwald ripening is strongly suppressed on ATO support, which can be explained with a potential-dependent switching of support oxide surface conductivity. This electrochemical transistor effect represents an important design principle for the development of optimized metal oxide support materials that protect supported Pt nanoparticles at high potentials, where careful consideration of the metal oxide flat-band potential is required in order to maintain high catalyst performance at normal PEFC cathode operation conditions at the same time