22 research outputs found
The brave new world of endometrial cancer Future implications for adjuvant treatment decisions
Purpose For many decades, endometrial cancer (EC) has been considered as a homogenous tumor entity with good prognosis. The currently valid risk stratification considers clinical and pathological factors. Treatment recommendations differ considerably from country to country. Materials and methods The Cancer Genome Atlas (TCGA) Research Network has shown that ECs should be reclassified into four novel molecular prognostic groups, with the potential of changing adjuvant management of EC patients: ultra-mutated, hyper-mutated, copy-number low, and copy-number high. Clinical examples are shown, and the available literature has been highlighted. The European Society of Gynaecological Oncology (ESGO) guideline for endometrial cancer takes the new classification system into consideration for adjuvant treatment decisions and will be published this year. Results In the near future, we expect new treatment recommendations that may differ considerably from the clinicopathologically driven recommendations on the basis of our deeper insight and better understanding of molecular markers in endometrial cancer. The PORTEC 4a study is the only recruiting study which randomizes patients to adjuvant or no adjuvant treatment on the basis of the aforementioned new classification system. Conclusion The aim of the new classification is a more personalized adjuvant radio(chemo)therapy decision and better oncologic outcomes or avoidance of overtreatment
Entwicklung eines Laserinterferometersystems zum direkten Erfassen von raeumlichen Bewegungen im Maschinenbau Abschlussbericht
TIB Hannover: FR 1251 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman
Stabilization of Pt Nanoparticles Due to Electrochemical Transistor Switching of Oxide Support Conductivity
Polymer
electrolyte fuel cells (PEFCs) offer an efficient way of
chemical-to-electrical energy conversion that could drastically reduce
the environmental footprint of the mobility and stationary energy
supply sectors, respectively. However, PEFCs can suffer from severe
degradation during start/stop events, when the cathode catalyst is
transiently exposed to very high potentials. In an attempt to mitigate
corrosion of conventional carbon support materials for Pt catalyst
nanoparticles under these conditions, conductive metal oxides like
antimony-doped tin oxide (ATO) are considered alternative support
materials with improved corrosion resistance. A combined in situ anomalous
small-angle X-ray scattering and post mortem transmission electron
microscopy study reveals PEFC-relevant degradation properties of ATO-supported
Pt in comparison to carbon-supported Pt catalysts. Against expectation,
the superior stability of ATO-supported Pt nanoparticles cannot be
merely explained by improved support corrosion resistance. Instead,
the dominant loss mechanism of electrochemical Ostwald ripening is
strongly suppressed on ATO support, which can be explained with a
potential-dependent switching of support oxide surface conductivity.
This electrochemical transistor effect represents an important design
principle for the development of optimized metal oxide support materials
that protect supported Pt nanoparticles at high potentials, where
careful consideration of the metal oxide flat-band potential is required
in order to maintain high catalyst performance at normal PEFC cathode
operation conditions at the same time