Report on Phase Two: The readiness to practise of NQSWs.

fals

Differentiation of dementia with Lewy bodies from Alzheimer's disease using a dopaminergic presynaptic ligand

Background: Dementia with Lewy bodies (DLB) is one of the main differential diagnoses of Alzheimer's disease (AD). Key pathological features of patients with DLB are not only the presence of cerebral cortical neuronal loss, with Lewy bodies in surviving neurones, but also loss of nigrostriatal dopaminergic neurones, similar to that of Parkinson's disease (PD). In DLB there is 40-70% loss of striatal dopamine.Objective: To determine if detection of this dopaminergic degeneration can help to distinguish DLB from AD during life.Methods: The integrity of the nigrostriatal metabolism in 27 patients with DLB, 17 with AD, 19 drug naive patients with PD, and 16 controls was assessed using a dopaminergic presynaptic ligand, I-123-labelled 2beta-carbomethoxy-3beta-(4-iodophenyl)-N-(3-fluoropropyl)nortropane (FP-CIT), and single photon emission tomography (SPET). A SPET scan was carried out with a single slice, brain dedicated tomograph (SME 810) 3.5 hours after intravenous injection of 185 MBq FP-CIT. With occipital cortex used as a radioactivity uptake reference, ratios for the caudate nucleus and the anterior and posterior putamen of both hemispheres were calculated. All scans were also rated by a simple visual method.Results: Both DLB and PD patients had significantly lower uptake of radioactivity than patients with (p<0.01) and controls (p<0.001) in the caudate nucleus and the anterior and posterior Putamen.Conclusion: FP-CIT SPET provides a means of distinguishing DLB from AD during life

The use of biomarkers in Alzheimer's disease: a case report

Uncertainties remain around the use of biomarkers in clinical practice to diagnose Alzheimer's disease. There are several implications for both patients and clinicians, including the ethical and practical dilemmas of identifying a disease process early in its course when there are no disease‐modifying treatments available

Extinction Map of Baade's Window

Recently Wo\'zniak \& Stanek (1996) proposed a new method to investigate interstellar extinction, based on two band photometry, which uses red clump stars as a means to construct the reddening curve. I apply this method to the color-magnitude diagrams obtained by the Optical Gravitational Lensing Experiment (OGLE) to construct an extinction map of $(40')^2$ region of Baade's Window, with resolution of $\sim30\;arcsec$. Such a map should be useful for studies of this frequently observed region of the Galactic bulge. The map and software useful for its applications are available via {\tt anonymous ftp}. The total extinction $A_V$ varies from $1.26\;mag$ to $2.79\;mag$ within the $(40')^2$ field of view centered on $(\alpha_{2000}, \delta_{2000}) =$ (18:03:20.9,--30:02:06), i.e. $(l,b)=(1.001,-3.885)$. The ratio $A_V/E(V-I) = 2.49\pm0.02$ is determined with this new method.Comment: revised version accepted for publication in ApJ Letters, 8 pages, uuencoded PostScript with 4 figures included; complete paper available through WWW at http://www.astro.princeton.edu/~library/prep.html; tables and auxiliary software available at ftp://www.astro.princeton.edu/stanek/Extinctio

Effect of Inclusion Rate of Silage With or Without the Presence of Alpha-Amylase on Feedlot Performance, Carcass Characteristics, and Efficiency Measures

The experimental objective was to determine the interactions of silage variety and inclusion level in cattle finishing diets on cattle performance and agronomic returns to cropland when fed to beef cattle

Warm-Dense Molecular Gas in the ISM of Starbursts, LIRGs and ULIRGs

The role of star formation in luminous and ultraluminous infrared galaxies is a hotly debated issue: while it is clear that starbursts play a large role in powering the IR luminosity in these galaxies, the relative importance of possible enshrouded AGNs is unknown. It is therefore important to better understand the role of star forming gas in contributing to the infrared luminosity in IR-bright galaxies. The J=3 level of 12CO lies 33K above ground and has a critical density of ~1.5 X 10^4 cm^-3. The 12CO(J=3-2) line serves as an effective tracer for warm-dense molecular gas heated by active star formation. Here we report on 12CO (J=3-2) observations of 17 starburst spirals, LIRGs and ULIRGs which we obtained with the Heinrich Hertz Submillimeter Telescope on Mt. Graham, Arizona. Our main results are the following: 1. We find a nearly linear relation between the infrared luminosity and warm-dense molecular gas such that the infrared luminosity increases as the warm-dense molecular gas to the power 0.92; We interpret this to be roughly consistent with the recent results of Gao & Solomon (2004a,b). 2. We find L_IR/M_H2 ratios ranging from ~10 to ~128 L_sun/M_sun using a standard CO-H2 conversion factor of 3 X 10^20 cm^-2 (K km s^-1)^-1. If this conversion factor is ~an order of magnitude less, as suggested in a recent statistical survey (Yao et al. 2003), then 2-3 of our objects may have significant contributions to the L_IR by dust-enshrouded AGNs.Comment: 15 Pages, 2 figures, Accepted for Publication in Ap

Coulomb stress transfer and fault interaction over millennia on non-planar active normal faults: TheMw 6.5-5.0 seismic sequence of 2016-2017, central Italy

In order to investigate the importance of including strike-variable geometry and the knowledge of historical and palaeoseismic earthquakes when modelling static Coulomb stress transfer and rupture propagation, we have examined the August-October 2016 A.D. and January 2017 A.D. central Apennines seismic sequence (Mw 6.0, 5.9, 6.5 in 2016 A.D. (INGV) and Mw 5.1, 5.5, 5.4, 5.0 in 2017 A.D. (INGV)).We model both the coseismic loading (from historical and palaeoseismic earthquakes) and interseismic loading (derived from Holocene fault slip-rates) using strike-variable fault geometries constrained by fieldwork. The inclusion of the elapsed times from available historical and palaeoseismological earthquakes and on faults enables us to calculate the stress on the faults prior to the beginning of the seismic sequence. We take account the 1316-4155 yr elapsed time on the Mt. Vettore fault (that ruptured during the 2016 A.D. seismic sequence) implied by palaeoseismology, and the 377 and 313 yr elapsed times on the neighbouring Laga and Norcia faults respectively, indicated by the historical record. The stress changes through time are summed to show the state of stress on the Mt. Vettore, Laga and surrounding faults prior to and during the 2016-2017 A.D. sequence. We show that the build up of stress prior to 2016 A.D. on strike-variable fault geometries generated stress heterogeneities that correlate with the limits of the main-shock ruptures. Hence, we suggest that stress barriers appear to have control on the propagation and therefore the magnitudes of the main-shock ruptures

Nutritional quality of Australian breakfast cereals - are they improving?

Abstract of paper that presented at The 16th International Congress of Dietetics, 5-8 Sep, 2012, Sydney