Zingerone alleviates the delayed ventricular repolarization and AV conduction in diabetes: Effect on cardiac fibrosis and inflammation - Fig 1

<p>The impact of 20 mg/kg zingerone orally administered every day on cardiac ECG parameters QT (A), QTc (B), PR interval (C) and P-duration (D) in rats with diabetes (D) induced with 50 mg/kg streptozotocin and in control rats. (E) are representative cardiac ECG recordings. Expression of values takes the form of mean ± SD for N = 6–8 rats. According to the one-way ANOVA and Newman Keuls’ post-hoc test, by comparison to the control group value and D group value, *P<0.05 and ^#P<0.05, respectively.</p

The impact of 20 mg/kg zingerone orally administered every day on urine 8-isoprostane level and serum uric acid level in rats with diabetes (D) induced with 50 mg/kg streptozotocin and in control rats.

<p>Expression of values takes the form of mean ± SD for N = 6–8 rats. According to the one-way ANOVA and Newman Keuls’ post-hoc test, by comparison to the control group value and D group value, *P<0.05 and ^#P<0.05, respectively.</p

The impact of 20 mg/kg zingerone (Z) orally administered every day on collagen deposition in heart longitudinal (LS) and transverse (TS) sections stained with Masson Trichrome of rats with diabetes (D) induced with 50 mg/kg streptozotocin and in control (C) rats.

<p>Collagen fibres are stained blue. The solid arrows indicate degenerated cardiac muscle fibers, hollow stars indicate patches of fibrous tissue.</p