De Novo Synthesis of 1,4-Dihydropyridines and Pyridines

An efficient and general method for the synthesis of 1,4-dihydropyridines and pyridines based on a lithiation/isomerization/intramolecular carbolithiation sequence is reported. This procedure provides an efficient, divergent, and straightforward entry to a wide range of polysubstituted dihydropyridines and pyridines starting from readily available <i>N</i>-allyl-ynamides

Intramolecular Carbocupration of <i>N</i>‑Aryl-ynamides: A Modular Indole Synthesis

A modular indole synthesis based on an intramolecular 5-<i>endo</i>-<i>dig</i> carbocupration starting from readily available <i>N</i>-aryl-ynamides is reported. A variety of ynamides are converted to indoles in moderate to good yields and with varying substitution pattern on the indole ring. This further extends the synthetic utility of ynamides in organic synthesis and provides additional insights on the use of intramolecular carbometalation reactions